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Yongli Fu, Yaowu Sun, Jiankun Zhang and Yu Cheng

Introduction The past two decades have witnessed great progress on the research regarding optimal glycemic control strategy for critically ill patients based on several randomized controlled trials (RCTs). However, there are still debates on

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K Amrein, A Papinutti, E Mathew, G Vila and D Parekh

acutely relevant to the specialty of critical care? In fact, it now transpires that the high prevalence of vitamin D deficiency in critically ill adults and children, combined with the pleiotropic effects of vitamin D, could indeed be of great importance

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Arno Téblick, Lies Langouche and Greet Van den Berghe

replacement therapy or broad-spectrum antibiotics, the majority of critically ill patients will survive the acute phase of their illness. However, a significant number of patients admitted to the ICU fail to recover sufficiently within a few days and enter a

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Zhou-Qing Kang, Jia-Ling Huo and Xiao-Jie Zhai

controlled trial (RCT) in 2001, which has proved the obvious effects of intensive insulin therapy (IIT, maintain blood glucose at a level no higher than 110 mg/dL) on the reduced morbidity and mortality among critically ill patients after surgery ( 7 ). This

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Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag and Henriette Kirchner

expression of the relevant genes in our biopsy collection. As expected, we could not detect SLCO1C1 , DIO2 and DIO3 transcripts. DIO3 has been described in human fetal liver and adult livers of critically ill patients, but in line with our findings, it

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Clara Odilia Sailer, Sophia Julia Wiedemann, Konrad Strauss, Ingeborg Schnyder, Wiebke Kristin Fenske and Mirjam Christ-Crain

the inflammatory response. Furthermore, as mentioned earlier, the increase in glucose levels which commonly occurs in critically ill patients is known to induce inflammation ( 18 ). According to our results, a short increase into the hyperosmotic

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R Perchard, L Magee, A Whatmore, F Ivison, P Murray, A Stevens, M Z Mughal, S Ehtisham, J Campbell, S Ainsworth, M Marshall, M Bone, I Doughty and P E Clayton

). Furthermore, single-dose vitamin D treatment in critically ill patients has been shown to have no effect on length of stay in hospital ( 36 ). In conclusion, this is the first prospective UK-based study examining the effect of vitamin D treatment on HbA1c

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Maxime Duval, Kalyane Bach-Ngohou, Damien Masson, Camille Guimard, Philippe Le Conte and David Trewick

.pone.0132788 ) 26172117 10.1371/journal.pone.0132788 2 Zhang Z Xu X Ni H Deng H. Predictive value of ionized calcium in critically ill patients: an analysis of a large clinical database MIMIC II . PLoS ONE 2014 9 e95204 . ( https://doi.org/10

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Amir Bashkin, Eliran Yaakobi, Marina Nodelman and Ohad Ronen

analysis. References 1 Fliers E Bianco AC Langouche L Boelen A. Thyroid function in critically ill patients . Lancet Diabetes and Endocrinology 2015 3 816 – 825 . ( https://doi.org/10.1016/S2213-8587(15)00225-9 ) 10.1016/S2213

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Madalena von Hafe, João Sergio Neves, Catarina Vale, Marta Borges-Canha and Adelino Leite-Moreira

syndrome – is characterized by a rapid decline in plasma-free THs levels (free T3 and free T4), with a marked elevation of rT3 in critically ill patients ( 69 ). TSH level is usually within the reference range, except in severe cases of this syndrome. Local