Lingjuan Li
Lingjuan Li
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Jing Qin
Jing Qin
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Lin Ren
Lin Ren
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Shiyuan Xiang
Shiyuan Xiang
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Xiaoyun Cao
Xiaoyun Cao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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Xianglan Zheng
Xianglan Zheng
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Zhiwen Yin
Zhiwen Yin
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Nidan Qiao
Nidan Qiao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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Introduction Craniopharyngioma is an intracranial neoplasm that originates from the remnant of the craniopharyngeal duct. The tumor is located in the hypothalamic–pituitary region and is closely related to important structures such as the
Julia Beckhaus
Julia Beckhaus
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany
Division of Epidemiology and Biometry, Carl von Ossietzky University, Oldenburg, Germany
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Division of Epidemiology and Biometry, Carl von Ossietzky University, Oldenburg, Germany
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Svenja Boekhoff
Svenja Boekhoff
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany
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Katrin Scheinemann
Katrin Scheinemann
Pediatric Hematology-Oncology Center, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland
Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
Department of Pediatrics, McMaster Children’s Hospital and McMaster University, Hamilton, Ontario, Canada
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Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
Department of Pediatrics, McMaster Children’s Hospital and McMaster University, Hamilton, Ontario, Canada
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Freimut H Schilling
Freimut H Schilling
Department of Pediatrics, Division of Pediatric Hematology and Oncology, Children’s Hospital Lucerne, Lucerne, Switzerland
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Gudrun Fleischhack
Gudrun Fleischhack
Pediatrics III, University Hospital of Essen, Essen, Germany
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Gerhard Binder
Gerhard Binder
University Children’s Hospital, Pediatric Endocrinology, University Tübingen, Tübingen, Germany
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Brigitte Bison
Brigitte Bison
Diagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Torsten Pietsch
Torsten Pietsch
Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany
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Carsten Friedrich
Carsten Friedrich
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany
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Hermann L Müller
Hermann L Müller
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany
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Introduction Craniopharyngiomas (CPs) are rare, benign tumors (WHO grade I) ( 1 ) of the sellar region with an incidence of 0.5 to 2 new cases per million persons per year ( 2 , 3 , 4 , 5 ). The age distribution at CP diagnosis has two
Agnieszka Bogusz
Agnieszka Bogusz
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland
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Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland
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Svenja Boekhoff
Svenja Boekhoff
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
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Monika Warmuth-Metz
Monika Warmuth-Metz
Department of Neuroradiology, University Hospital, Würzburg, Germany
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Gabriele Calaminus
Gabriele Calaminus
Department of Pediatric Oncology and Hematology, University Hospital, Bonn, Germany
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Maria Eveslage
Maria Eveslage
Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany
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Hermann L Müller
Hermann L Müller
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
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Introduction Craniopharyngiomas (CPs) are rare, histologically benign (WHO I°), embryonal malformations of the sellar/parasellar area originating from neoplastic transformation of ectodermal-derived epithelial cell remnants of Rathke’s pouch
Julia Beckhaus
Julia Beckhaus
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany
Division of Epidemiology and Biometry, Carl von Ossietzky Universität, Oldenburg, Germany
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Division of Epidemiology and Biometry, Carl von Ossietzky Universität, Oldenburg, Germany
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Maria Eveslage
Maria Eveslage
Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany
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Brigitte Bison
Brigitte Bison
Diagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Carsten Friedrich
Carsten Friedrich
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany
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Hermann L Müller
Hermann L Müller
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany
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Introduction Craniopharyngiomas (CP) are rare embryonic malformations, which arise from ectoblastic remnants of Rathke’s pouch. Thus, CP can be found anywhere along the path of development of Rathke’s pouch in hypothalamic and pituitary
H Vlaardingerbroek
H Vlaardingerbroek
Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands
Willem-Alexander Children’s Hospital, Department of Pediatrics, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
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Willem-Alexander Children’s Hospital, Department of Pediatrics, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
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E L T van den Akker
E L T van den Akker
Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands
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A C S Hokken-Koelega
A C S Hokken-Koelega
Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands
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-melanotropin; β-MSH, β-melanotropin. The aim of this review is to present data on the extreme ends of the obesity spectrum in patients with Prader–Willi syndrome (PWS), Bardet–Biedl syndrome (BBS), acquired hypothalamic obesity in craniopharyngioma
Nidan Qiao
Nidan Qiao
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
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Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
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predictors and outcome are known; but in unsupervised machine learning, only the predictors are fed into the algorithm. The most common type of tumors originated in the sellar region included pituitary neoplasm, craniopharyngioma, meningioma and chordoma
I M A A van Roessel
I M A A van Roessel
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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J P de Graaf
J P de Graaf
Dutch Pituitary Foundation, Nijkerk, The Netherlands
Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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N R Biermasz
N R Biermasz
Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Endo-ERN European Reference Network on Rare endocrine conditions
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E Charmandari
E Charmandari
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Aghia Sophia Children's Hospital, Athens, Greece
Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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H M van Santen
H M van Santen
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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, 3 ). Craniopharyngioma is the most common suprasellar tumor to result in HD; however, HD is also encountered following the diagnosis and treatment of suprasellar low-grade glioma (LGG) and less frequent genetic causes ( 1 , 4 , 5 ). HD following
Kunal Thakkar
Kunal Thakkar
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Swati Ramteke-Jadhav
Swati Ramteke-Jadhav
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Rajeev Kasaliwal
Rajeev Kasaliwal
Department of Endocrinology, Mahatma Gandhi Medical College & Hospital, Jaipur, India
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Saba Samad Memon
Saba Samad Memon
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Virendra Patil
Virendra Patil
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Puja Thadani
Puja Thadani
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Nilesh Lomte
Nilesh Lomte
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Shilpa Sankhe
Shilpa Sankhe
Department of Radiology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Atul Goel
Atul Goel
Department of Neurosurgery, Seth G S Medical College & KEM Hospital, Mumbai, India
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Sridhar Epari
Sridhar Epari
Department of Pathology, Tata Memorial Centre, Mumbai, India
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Naina Goel
Naina Goel
Department of Neuropathology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Anurag Lila
Anurag Lila
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Tushar Bandgar
Tushar Bandgar
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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non-neoplastic etiologies can be found in this region ( 1 ). Pituitary adenomas are the commonest SSR tumors accounting for 85% of sellar masses ( 2 ). Amidst the non-adenoma masses, other common sellar lesions include craniopharyngioma (CR, 12
J Van Schaik
J Van Schaik
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M Burghard
M Burghard
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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M H Lequin
M H Lequin
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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E A van Maren
E A van Maren
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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A M van Dijk
A M van Dijk
Department of Dietetics, University Medical Center Utrecht, Utrecht, The Netherlands
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T Takken
T Takken
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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L B Rehorst-Kleinlugtenbelt
L B Rehorst-Kleinlugtenbelt
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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B Bakker
B Bakker
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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L Meijer
L Meijer
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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E W Hoving
E W Hoving
Division of Neurosurgery, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M Fiocco
M Fiocco
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Institute of Mathematics, Leiden University, Leiden, The Netherlands
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Institute of Mathematics, Leiden University, Leiden, The Netherlands
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A Y N Schouten-van Meeteren
A Y N Schouten-van Meeteren
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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W J E Tissing
W J E Tissing
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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H M van Santen
H M van Santen
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Introduction Hypothalamic dysfunction (HD) during childhood may be present in children with craniopharyngioma, chiasmatic hypothalamic glioma, germinoma, as well as in children with certain genetic syndromes, such as Prader Willi syndrome ( 1
Nidan Qiao
Nidan Qiao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Haixia Cheng
Haixia Cheng
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Zhaoyun Zhang
Zhaoyun Zhang
Department of Endocrinology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Hongying Ye
Hongying Ye
Department of Endocrinology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Ming Shen
Ming Shen
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Xuefei Shou
Xuefei Shou
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Xiaoyun Cao
Xiaoyun Cao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Hong Chen
Hong Chen
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Xiang Zhou
Xiang Zhou
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Yongfei Wang
Yongfei Wang
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Yao Zhao
Yao Zhao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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pituitary adenomas or craniopharyngiomas before operation. Previous studies have suggested that PPTs are hypervascularized ( 3 , 4 ); thus, clinical suspicion of PPTs before surgery is a real challenge. Recent advances in endoscopic surgery have provided
