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Department and Graduate Institute of Forensic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
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studies (computed tomography (CT) or magnetic resonance imaging (MRI)). Adrenalectomy has consequently been established as the treatment of choice for unilateral disease. Recently, there has been a growing focus on a special group with cortisol co
Department of Neuroscience DNS, University of Padova, Padova, Italy
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Nuclear Medicine Unit, Department of Medicine – DIMED, University-Hospital of Padova, Padova, Italy
Padova Neuroscience Center PNC, University of Padova, Padova, Italy
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Department of Mathematics ‘Tullio Levi-Civita’ DM, University of Padova, Padova, Italy
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Introduction and aim
Ectopic ACTH secretion (EAS) is mostly secondary to thoracic/abdominal neuroendocrine tumours (NETs) or small cell-lung carcinoma (SCLC). We studied the diagnostic accuracy of CT with 68Ga-Dota derivatives (68Ga-SSTR) PET in localizing ACTH-secreting tumor in patients with EAS.
Materials and methods
68Ga-SSTR-PET/CT was performed and compared with the nearest enhanced CT in 18 cases (16 primary and 2 recurrent neoplasms). Unspecific, indeterminate and false-positive uptakes were assessed using conventional imaging, follow-up or histology.
Results
We diagnosed 13 thoracic (9 primary and 2 recurrent bronchial carcinoids, 2 SCLCs) and 1 abdominal (pancreatic NET) tumors. Eight ACTH-secreting tumors were promptly identified at EAS diagnosis (’overt’, four pulmonary carcinoids with two recurrences and two SCLC); six EAS have been discovered during the subsequent follow-up (’covert’, five bronchial carcinoids and one pancreatic NET). At the time of EAS diagnosis, imaging was able to correctly detect the ACTH-secreting tumour in 8/18 cases (6 new diagnosis and 2 recurrences). During the follow-up, six out of initially ten ‘occult’ cases became ‘covert’. At last available follow-up, CT and 68Ga-SSTR-PET/CT were able to diagnose 11/18 and 12/18 ACTH-secreting tumours, respectively (11/14 and 12/14 considering only overt and covert cases, respectively). Four cases have never been localized by conventional or nuclear imaging (’occult EAS’), despite an average follow-up of 5 years.
Conclusion
The 68Ga-SSTR-PET/CT is useful in localizing EAS, especially to enhance positive prediction of the suggestive CT lesions and to detect occult neoplasms.
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than patients with essential hypertension ( 12 ). However, the contribution of the different subtypes of PA to kidney stone disease remains poorly understood. Adrenal computed tomography (CT) is an essential component of the diagnosis of PA and is
EA GETBO 3878, University Hospital of Brest, Brest, France
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EA GETBO 3878, University Hospital of Brest, Brest, France
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EA GETBO 3878, University Hospital of Brest, Brest, France
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Department of Nuclear Medicine, University Hospital of Brest, Brest, France
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Department of Nuclear Medicine, University Hospital of Brest, Brest, France
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Department of Nuclear Medicine, University Hospital of Brest, Brest, France
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EA GETBO 3878, University Hospital of Brest, Brest, France
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Department of Nuclear Medicine, University Hospital of Brest, Brest, France
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carotid duplex ultrasonography varies from 9.4% to 27.0% ( 1 ). In cervical computed tomography (CT) and magnetic resonance imaging (MRI) scans, studies show a prevalence of TI nearly to 16% ( 2 , 3 ). The common use of 18F-fluorodeoxyglucose (FDG
Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand
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CRH production rather than Cushing’s disease (CD). Computed tomography (CT) of the chest, abdomen and pelvis was initially reported as normal. As no causative lesion was identified on imaging, the patient was transferred to a university hospital for
Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Division of Musculoskeletal Section, Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan
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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
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School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan
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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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this minimal risk research. Acknowledgements The authors thank all the clinical staff and experts responsible for conducting liver imaging (ultrasound, computed tomography, or magnetic resonance imaging) and DXA bone mineral density
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://www.iscd.org/documents/2015/06/2015-iscd-adult-official-positions.pdf ). Trabecular bone score was acquired from the lumbar spine DXA image automatically by the TBS iNsight software, Medimaps Group SA, Geneva, Switzerland. Quantitative computed tomography (QCT) was
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Department of Medicine, University of Padova, Padova, Italy
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, quantitative computed tomography, applied both to the appendicular skeleton and to the spine, peripheral DXA, digital x-ray radiogrammetry, radiographic absorptiometry, and other radiographic techniques, as reported in Table 1 ( 25 , 26 , 27 , 28 , 29
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computed tomography (CT) and magnetic resonance imaging (MRI) followed by functional imaging modalities ( 4 ). The functional imaging modalities that have been studied in EAS include metaiodobenzylguanidine scans in earlier days, followed by single
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. Diabetologia 2012 55 2733 – 2740 . ( doi:10.1007/s00125-012-2624-z ). 31 Jensen MD Kanaley JA Reed JE Sheedy PF . Measurement of abdominal and visceral fat with computed tomography and dual-energy X-ray absorptiometry . American Journal of