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Tingting Xia, Hongru Sun, Hao Huang, Haoran Bi, Rui Pu, Lei Zhang, Yuanyuan Zhang, Ying Liu, Jing Xu, Justina Ucheojor Onwuka, Yupeng Liu, Binbin Cui and Yashuang Zhao

Introduction Worldwide, colorectal cancer (CRC) remains among the top three prevalent tumors among women and men according to Global Cancer Statistics with an estimated 1.4 million new cases and 693,900 deaths occurring in 2012 ( 1

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Jordyn Silverstein, Wesley Kidder, Susan Fisher, Thomas A Hope, Samantha Maisel, Dianna Ng, Jessica Van Ziffle, Chloe E Atreya and Katherine Van Loon

States, colorectal cancer (CRC) is the third most common cause of cancer-related death ( 1 ). Over the past two decades, CRC incidence has declined by 3–4% each year ( 2 ). Consistent with CRC screening patterns ( 3 ), this decrease in CRC incidence is

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Corina Verónica Sasso, Flavia Eliana Santiano, Fiorella Campo Verde Arboccó, Leila Ester Zyla, Silvana Noemí Semino, Martin Eduardo Guerrero-Gimenez, Virginia Pistone Creydt, Constanza Matilde López Fontana and Rubén Walter Carón

Introduction Colorectal cancer (CRC) is the third most common cancer and one of the tumors with the highest incidence and mortality worldwide, with an increasing projection for the coming decades. CRC incidence and mortality rates are 30 and

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Djeda Belharazem, Matthias Kirchner, Franziska Geissler, Peter Bugert, Martin Spahn, Burkhard Kneitz, Hubertus Riedmiller, Christian Sauer, Stefan Küffer, Lutz Trojan, Christian Bolenz, Maurice Stephan Michel, Alexander Marx and Philipp Ströbel

detection and prevention. LOI of IGF2 has previously been described in normal circulating peripheral blood lymphocytes of individuals with an increased risk to develop colorectal cancer (11, 12, 13) . IGF2 and H19 belong to the same locus and share

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Katherine A Bolton, Kelly A Avery-Kiejda, Elizabeth G Holliday, John Attia, Nikola A Bowden and Rodney J Scott

analysis in our laboratory and by others, to be associated with earlier age at onset of hereditary non-polyposis colorectal cancer ( 36 , 37 , 38 ). Results of early studies also suggested an association between the absence of the common IGF1 19 CA

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Erika Urbano Lima, Ileana G S Rubio, Joaquim Custodio Da Silva, Ana Luiza Galrão, Danielle Pêssoa, Taise Cerqueira Oliveira, Fabiane Carrijo, Igor Silva Campos, Luciano Fonseca Espinheira, Luiz Jose Sampaio, Claudio Rogerio Lima, Janete Maria Cerutti and Helton Estrela Ramos

.2) promoter harbors CpG islands including the first exon and intron ( 13 ). Its epigenetic control has been correlated with tumorigenesis and worse prognosis in uterine, breast, esophageal, gastric, pancreatic and colorectal cancers ( 10 , 11 , 12 , 13

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Jakob Kirkegård, Dora Körmendiné Farkas, Jens Otto Lunde Jørgensen and Deirdre P Cronin-Fenton

262 individuals, more cases of hyperthyroidism were observed among esophageal cancer cases compared with their controls ( 6 ). In addition, T4 substitution therapy has been correlated with a decreased risk of colorectal cancer ( 7 ). Thus, the

Open access

Elham Barazeghi, Per Hellman, Gunnar Westin and Peter Stålberg

hypermethylation and loss of heterozygosity, with a putative tumor-suppressive role of PTPRM, was demonstrated in colorectal cancer ( 11 , 12 ). PTPRM has been shown to have a crucial role in epidermal growth factor receptor signaling, and downregulation of PTPRM

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Annette Mouritsen, Alexander Siegfried Busch, Lise Aksglaede, Ewa Rajpert-De Meyts and Anders Juul

some studies have observed associations between the deletion polymorphism of UGT2B17 with osteoporosis in males ( 2 ), prostate cancer ( 22 ), lower incidence of colorectal cancer in males ( 23 ), other studies observed no association with

Open access

Ishita Gupta, Allal Ouhtit, Adil Al-Ajmi, Syed Gauhar A Rizvi, Hamad Al-Riyami, Marwa Al-Riyami and Yahya Tamimi

). Our data are similar to those reported on colorectal cancer, where BRIP1 overexpression correlated with poor recurrence-free survival ( 40 ). Also, elevated expression of BRIP1 was observed in high-grade breast tumors correlated with an unfavorable