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Changjiao Yan, Meiling Huang, Xin Li, Ting Wang and Rui Ling

mutations were rarely studied in previous researches. Here, we investigated epidemiological characteristics that may be associated with the mutation of BRAF V600E and then studied the role of BRAF V600E mutation in the clinicopathological features of PTC

Open access

Dong Cen, Hui Liu, Zhe Wan, Zhongjie Lin, Yanting Wang, Junjie Xu and Yuelong Liang

explore the clinicopathological features and survival outcomes of GB-NEN patients using a population-based study based on the SEER database. Materials and methods Data source The data in this study were from the SEER*Stat Database (version 8

Open access

Hanbaro Kim, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Shadi Alshammary and Song Cheol Kim

assess the evolving trends in the clinicopathological features of PNETs by dividing a single-center patient series conducted over a 27-year period into three groups. Furthermore, this study evaluated the pattern and predictors of recurrence after curative

Open access

C Sui, Q He, R Du, D Zhang, F Li, G Dionigi, N Liang and H Sun

. Comparing the clinicopathological features of patients with N1a and N1b disease, we found that men had a 1.249 times higher risk of stage N1b disease than women. For every 1 cm increase in T size, the risk of stage N1b disease increased by 3

Open access

Shuang Ye, Yuanyuan Xu, Jiehao Li, Shuhui Zheng, Peng Sun and Tinghuai Wang

The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC). This study aimed to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Clinicopathologic features including age, menopausal status, tumor size, nuclear grade, lymph node metastasis, AJCC TNM stage, and ER, PR and HER-2 expression were evaluated from 249 TNBC cases. Immunohistochemical staining of GPER and Ezrin was performed on TNBC pathological sections. Kaplan–Meier analyses, as well as logistic regressive and Cox regression model tests were applied to evaluate the prognostic significance between different subgroups. Compared to the GPER-low group, the GPER-high group exhibited higher TNM staging (P = 0.021), more death (P < 0.001), relapse (P < 0.001) and distant events (P < 0.001). Kaplan–Meier analysis showed that GPER-high patients had a decreased OS (P < 0.001), PFS (P < 0.001), LRFS (P < 0.001) and DDFS (P < 0.001) than GPER-low patients. However, these differences in prognosis were not statistically significant in post-menopausal patients (OS, P = 0.8617; PFS, P = 0.1905; LRFS, P = 0.4378; DDFS, P = 0.2538). There was a significant positive correlation between GPER and Ezrin expression level (R = 0.508, P < 0.001) and the effect of Ezrin on survival prognosis corresponded with GPER. Moreover, a multivariable analysis confirmed that GPER and Ezrin level were both significantly associated with poor DDFS (HR: 0.346, 95% CI 0.182–0.658, P = 0.001; HR: 0.320, 95% CI 0.162–0.631, P = 0.001). Thus, overexpression of GPER and Ezrin may contribute to aggressive behavior and indicate unfavorable prognosis in TNBC; this may correspond to an individual’s estrogen levels.

Open access

Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh and Tetsuo Kondo

-analysis was to investigate the clinicopathological features of PTC-TCF in comparison with TCVPTC and classical PTC to clarify the controversial issue. Methods Search strategy and study identification We searched four main electronic databases

Open access

Lauren E Henke, John D Pfeifer, Thomas J Baranski, Todd DeWees and Perry W Grigsby

large single-institution study with long follow-up to directly compare clinicopathologic features and outcomes of the two subtypes, with pathology criteria that exclude NIF-TP, is needed. Similarly, while the prevalence of common somatic mutations has

Open access

Guoquan Zhu, Yuying Deng, Liqin Pan, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang, Yanying Chen and Jiaxin Luo

mean ±  s.d . The clinicopathologic features among groups that were categorical variables were compared using Fisher’s exact test and Pearson’s chi-squared test. A Student’s t test was used for normally distributed continuous variables, and a Mann

Open access

Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi and Lewis Hassell

considered. TERT promoter mutations, the more recently discovered mutations in thyroid cancer, have been found to correlate with aggressive clinicopathological features and poor outcomes in PTCs ( 8 , 19 , 44 ). Our pooled analyses show a promising value

Open access

Manjeetkaur Sehemby, Prachi Bansal, Vijaya Sarathi, Ashwini Kolhe, Kanchan Kothari, Swati Jadhav-Ramteke, Anurag R Lila, Tushar Bandgar and Nalini S Shah

2565 – 2572 . 11 Zhang H-Y Zhu J-E Huang W Zhu J. Clinicopathologic features of ovarian Sertoli-Leydig cell tumors . International Journal of Clinical and Experimental Pathology 2014 7 6956 – 6964 . 12 Yance VRV Marcondes JAM Rocha MP