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Cheng Han Ng Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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Yip Han Chin Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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Marcus Hon Qin Tan Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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Jun Xuan Ng Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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Samantha Peiling Yang Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Department of Medicine, National University Hospital, Singapore

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Jolene Jiayu Kiew Department of Medicine, National University Hospital, Singapore

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Chin Meng Khoo Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Department of Medicine, National University Hospital, Singapore

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-surgical option as a bridging therapy to parathyroidectomy would be required to control hypercalcemia while awaiting surgery. Cinacalcet is a positive allosteric modulator of the calcium sensing receptor (CaSR) that increases the sensitivity of the CaSR on the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0221
Volume/Issue:
Volume 9: Issue 7
Open access
Daniel Bell Department of Pharmacy, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Julia Hale Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Cara Go Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Ben G Challis Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Tilak Das Department of Radiology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Brian Fish Department of Head and Neck Surgery, Cambridge University NHS Foundation Trust, Cambridge, UK

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Ruth T Casey Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
Department of Medical Genetics, Cambridge University, Cambridge, UK

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meeting criteria for surgery do not proceed to PTX due to increased surgical and/or anaesthetic risk, or patient preference. In this cohort of patients, medical management with cinacalcet can be considered, and cinacalcet therapy is routinely commissioned

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0258
Volume/Issue:
Volume 10: Issue 11
Open access
Sondra O’Callaghan Endocrinology, Diabetes & Metabolism, Orlando VA Healthcare System, Orlando, Florida, USA

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Hanford Yau Endocrinology, Diabetes & Metabolism, Orlando VA Healthcare System, Orlando, Florida, USA

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-secreting C-cells of the thyroid, it mediates the stimulatory action of high calcium on calcitonin secretion. Cinacalcet is a calcimimetic that directly lowers PTH levels by increasing the sensitivity of the CaSR to extracellular calcium. In 1998, the first

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0487
Volume/Issue:
Volume 10: Issue 1
Open access
Anna Eremkina Endocrinology Research Center, Russian Federation, Moscow, Russia

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Julia Krupinova Endocrinology Research Center, Russian Federation, Moscow, Russia

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Ekaterina Dobreva Endocrinology Research Center, Russian Federation, Moscow, Russia

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Anna Gorbacheva Endocrinology Research Center, Russian Federation, Moscow, Russia

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Ekaterina Bibik Endocrinology Research Center, Russian Federation, Moscow, Russia

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Margarita Samsonova Faculty of Fundamental Medicine, ederal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State University, Moscow, Russia

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Alina Ajnetdinova Endocrinology Research Center, Russian Federation, Moscow, Russia

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Natalya Mokrysheva Endocrinology Research Center, Russian Federation, Moscow, Russia

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hypercalcemia, but they have some limitations such as significant nephrotoxicity, like pamidronate-induced glomerulosclerosis and acute tubular necrosis. Although cinacalcet has been successfully applied in PHPT, it has been discontinued prematurely due to its

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0380
Volume/Issue:
Volume 9: Issue 10
Open access
Jennifer Walsh The Mellanby Centre for Bone Research, The Medical School, The University of Sheffield, Sheffield, UK

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Neil Gittoes Centre for Endocrinology, Diabetes and Metabolism, University Hospitals Birmingham & University of Birmingham, Birmingham Health Partners, Birmingham, UK

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Peter Selby Department of Medicine, Manchester Royal Infirmary, Manchester, UK

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the Society for Endocrinology Clinical Committee The Society for Endocrinology, 22 Apex Court, Woodlands, Bradley Stoke, Bristol, UK

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. Calcified Tissue International 1990 46 (Supplement) S26 – S30 . 5 Marcocci C Chanson P Shoback D Bilezikian J Fernandez-Cruz L Orgiazzi J Henzen C Cheng S Sterling LR Lu J Cinacalcet reduces serum calcium

Article Type:
Other
DOI:
https://doi.org/10.1530/EC-16-0055
Volume/Issue:
Volume 5: Issue 5
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Maria Mizamtsidi Department of Endocrinology, Diabetes and Metabolism, Hellenic Red Cross Hospital, Athens, Greece

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Constantinos Nastos Second Department of Surgery, Endocrine Surgery Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece

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George Mastorakos Unit of Endocrinology, Diabetes and Metabolism, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Roberto Dina Department of Pathology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK

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Ioannis Vassiliou Second Department of Surgery, Endocrine Surgery Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Maria Gazouli Department of Basic Medical Sciences, Laboratory of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Fausto Palazzo Department of Thyroid and Endocrine Surgery, Imperial College London, London, UK

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are unable or unwilling to undergo PTx ( 11 ). Another option is cinacalcet, a calcimimetic agent, which lowers serum calcium and PTH by increasing the sensitivity of the CaSR to extracellular calcium, thereby decreasing serum PTH and reducing the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0283
Volume/Issue:
Volume 7: Issue 2
Open access
Martine Cohen-Solal Department of Skeletal Diseases, INSERM U1132 & Université de Paris, Hôpital Lariboisière, Paris, France

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Thomas Funck-Brentano Department of Skeletal Diseases, INSERM U1132 & Université de Paris, Hôpital Lariboisière, Paris, France

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Pablo Ureña Torres AURA Nord, Saint Ouen, France
Department of Renal Physiology, Necker Hospital, Université de Paris, Paris, France

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level, cinacalcet should be proposed as it has been shown to reduce fracture rate in older dialysis patients with SHPT ( 57 ). In case of resistance to cinacalcet, a parathyroidectomy should be considered. Figure 2 Proposed algorithm for treatment

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0039
Volume/Issue:
Volume 9: Issue 4
Open access
Ravikumar Shah Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

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Anurag R Lila Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

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Ramteke-Swati Jadhav Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

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Virendra Patil Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

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Abhishek Mahajan Department of Radiodiagnosis and Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India

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Sushil Sonawane Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

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Puja Thadani Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

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Anil Dcruz Department of Head Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India

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Prathamesh Pai Department of Head Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India

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Munita Bal Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India

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Subhada Kane Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India

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Nalini Shah Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

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Tushar Bandgar Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

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66 Bergwitz (61) 56 M Mandible 228 PE 870 Ru/ml (N <180) NA Persistence Multiple surgeries, cinacalcet Ameloblastic fibrosarcoma 67 Monappa (62) 35 M Right mandible 36 PE NA NA No – PMTMCT 68

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0341
Volume/Issue:
Volume 8: Issue 10
Open access
Maxime Duval Department of Medicine, Clinique Jules Verne, Nantes, France

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Kalyane Bach-Ngohou Department of Biology, Laboratory of Clinical Biochemistry, CHU Nantes, Nantes, France

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Damien Masson Department of Biology, Laboratory of Clinical Biochemistry, CHU Nantes, Nantes, France

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Camille Guimard Department of Emergency Medicine, CHU Nantes, Nantes, France

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Philippe Le Conte Department of Emergency Medicine, CHU Nantes, Nantes, France

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David Trewick Department of Medicine, Clinique Jules Verne, Nantes, France
Department of Emergency Medicine, CHU Nantes, Nantes, France

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35 (26.3)  Thiazide diuretics 9 (6.8)  Amiodarone 7 (5.3)  Cinacalcet 6 (4.5) Results are presented as median (Q1–Q3) or number of patients and proportion (%) when appropriate. The relevant biological data

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0267
Volume/Issue:
Volume 7: Issue 10
Open access
Sara Lomelino Pinheiro Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Ana Saramago Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Branca Maria Cavaco Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Carmo Martins Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Valeriano Leite Serviço de Endocrinologia e Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Tiago Nunes da Silva Serviço de Endocrinologia e Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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upper and the right lower parathyroid glands). The patient was started on cinacalcet and 4 mg zoledronic acid monthly due to recurrent severe hypercalcemia of 14.2 mg/dL. However, despite a progressive increase in cinacalcet dose (maximum tolerated dose

Article Type:
Research Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-22-0479
Volume/Issue:
Volume 12: Issue 9
Open access