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Małgorzata Fuksiewicz, Maria Kowalska, Agnieszka Kolasińska-Ćwikła, Jarosław B Ćwikła, Łukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel, and Beata Kotowicz

monitoring use the ability of NEN cells to release non-specific markers into the bloodstream. The determination of non-specific marker – chromogranin A (CgA) – is applied in clinical practice ( 2 , 3 ). This substance belongs to acid glycoproteins

Open access

Irvin M Modlin, Harry Aslanian, Lisa Bodei, Ignat Drozdov, and Mark Kidd

has remained a substantial technical challenge. A diverse variety of potential biomarkers has been proposed to be of utility in NET disease (2, 3, 4, 5) . These include the constitutive neurosecretory protein chromogranin A (CgA) as well as individual

Open access

Maria Angela D'amico, Barbara Ghinassi, Pascal Izzicupo, Lamberto Manzoli, and A Di Baldassarre

, neurotransmitters, or amines in response to a variety of physiological and pharmacological stimuli. Nine members of the granin family have been presently described: chromogranins, namely chromogranins A (CgA) and B (CgB), and secretogranins, namely SgII, 1B1075

Open access

Yang Lv, Xu Han, Chunyan Zhang, Yuan Fang, Ning Pu, Yuan Ji, Dansong Wang, Xu Xuefeng, and Wenhui Lou

, the identification of such a useful serological marker is in pressing need. Chromogranin A (CgA), the first identified representative of granins, is produced and excreted by granules within both the classical endocrine glands and the diffuse

Open access

R C S van Adrichem, L J Hofland, R A Feelders, M C De Martino, P M van Koetsveld, C H J van Eijck, R R de Krijger, D M Sprij-Mooij, J A M J L Janssen, and W W de Herder

Introduction Gastroenteropancreatic neuroendocrine tumors (GEP NETs) are rare and heterogeneous tumors which may vary according to their biological, functional, and clinical behavior (1) . Chromogranin A (CgA) and the Ki-67 proliferation index are

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Jens P Goetze, Linda M Hilsted, Jens F Rehfeld, and Urban Alehagen

from the adrenal medulla is chromogranin A, or CgA (1) . CgA measurement in plasma has a central role in the diagnosis and treatment follow-up of neuroendocrine tumors, since these tumors often produce vast amounts of CgA (2, 3, 4) . In the

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T Szarvas, B Jardin-Watelet, N Bourgoin, M J Hoffmann, P Nyirády, C Oláh, T Széll, A Csizmarik, B Hadaschik, and H Reis

Introduction Chromogranin A (CGA) is a 49 kDa glycoprotein encoded by the chromogranin A gene on chromosome 14q32.12. It belongs to the granin family of secretory proteins that are ubiquitous in the nervous, endocrine and immune systems. It is

Open access

Matteo Scopel, Eugenio De Carlo, Francesca Bergamo, Sabina Murgioni, Riccardo Carandina, Anna Rita Cervino, Marta Burei, Federica Vianello, Vittorina Zagonel, Matteo Fassan, and Roberto Vettor

in both these groups the relationship between bone metastases, primary type/site of NET, laboratory parameters (chromogranin A (CgA), calcium, phosphate, parathyroid hormone (PTH) and vitamin D) and proliferation markers (Ki-67 and mitotic index

Open access

Anna Malczewska, Kjell Oberg, and Beata Kos-Kudla

prognostic studies (REMARK) . Journal of the National Cancer Institute 2005 97 1180 – 1184 . ( ) 5 O'Connor DT Bernstein KN Radioimmunoassay of chromogranin A in plasma as a measure of exocytotic

Open access

Roxanne C S van Adrichem, Aart Jan van der Lely, Martin Huisman, Piet Kramer, Richard A Feelders, Patric J D Delhanty, and Wouter W de Herder

, nondiabetic NET patients ( N =28) and age- (±3 years) and sex-matched nonobese, nondiabetic controls ( N =28); and (ii) study the relationship between AG, UAG, and AG/UAG ratios and biochemical (chromogranin-A (CgA) and neuron-specific enolase (NSE) levels