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Vickie Braithwaite, Kerry S Jones, Shima Assar, Inez Schoenmakers, and Ann Prentice

Introduction Elevated plasma C-terminal fibroblast growth factor 23 (C-FGF23) concentrations have been recorded in Gambian children with putative Ca-deficiency rickets (1) and, at a lower prevalence, in apparently healthy children from the local

Open access

Thomas Reinehr, Alberto Sánchez-Guijo, Nina Lass, and Stefan A Wudy

Introduction Obesity is a complex condition associated with changes in many steroid hormones also including androgens: concentrations of testosterone and DHEAS and their precursors are increased in children ( 1 , 2 ) and obese women ( 3

Open access

Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen, and Anders Juul

( 4 ) and obesity ( 5 ) in adults and obesity ( 6 ) in children. Phthalates are used as softeners in PVC plastics. As phthalates are continuously emitted from PVC, humans can be exposed through ingestion, inhalation or by dermal contact ( 7

Open access

Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo, and Carla Giordano

relationship between GH and gonadal steroid levels in children is difficult to establish because steroid levels are very low prior to puberty. Therefore, although the clinical features related to sexual dimorphism of the somatotroph axis have been well

Open access

Anastasia Ibba, Francesca Corrias, Chiara Guzzetti, Letizia Casula, Mariacarolina Salerno, Natascia di Iorgi, Gianluca Tornese, Giuseppa Patti, Giorgio Radetti, Mohamad Maghnie, Marco Cappa, and Sandro Loche

do not exclude GHD. In the current retrospective study we aimed to define the best IGF1 SDS diagnostic cut-off using a standardized assay in a large cohort of children and adolescents with short stature. Furthermore, we wanted to evaluate through

Open access

Giorgio Radetti, Mariacarolina Salerno, Chiara Guzzetti, Marco Cappa, Andrea Corrias, Alessandra Cassio, Graziano Cesaretti, Roberto Gastaldi, Mario Rotondi, Fiorenzo Lupi, Antonio Fanolla, Giovanna Weber, and Sandro Loche

started in patients with either subclinical (high TSH with normal fT4) or overt hypothyroidism (subnormal fT4 and increased TSH). There is no consensus on the timing to start or discontinue therapy based on TSH concentrations in children and adolescents

Open access

Mardia López-Alarcón, Jessie N Zurita-Cruz, Alonso Torres-Rodríguez, Karla Bedia-Mejía, Manuel Pérez-Güemez, Leonel Jaramillo-Villanueva, Mario E Rendón-Macías, Jose R Fernández, and Patricia Martínez-Maroñas

anxiety associated with obesity have been found in up to 86% of cases ( 2 , 3 ). Most treatment strategies in children aim to improve life styles through dietary or physical activity approaches only. In the last decade, several studies have included

Open access

Giorgio Bedogni, Andrea Mari, Alessandra De Col, Sofia Tamini, Amalia Gastaldelli, and Alessandro Sartorio

Introduction The prevalence of childhood type 2 diabetes mellitus (T2DM) is rapidly increasing worldwide ( 1 ). T2DM is characterized by visceral obesity, insulin resistance and defective β-cell function. In children and adolescents, glucose

Open access

Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant, and Agnès Linglart

therapy for CD in children, its efficacy and safety in this context has not been reported so far. We describe here the efficacy and safety of mitotane as treatment of CD in nine children in comparison to 13 patients cured by TSS. Table 1 Synopsis of

Open access

Søs Dragsbæk Larsen, Christine Dalgård, Mathilde Egelund Christensen, Sine Lykkedegn, Louise Bjørkholt Andersen, Marianne Andersen, Dorte Glintborg, and Henrik Thybo Christesen

adulthood ( 2 , 3 ), making it essential to prevent high BP in children. Identification of modifiable, early risk factors is a key in designing initiatives preventing future cardio-vascular events. Recently, hypovitaminosis D, defined as serum 25