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Keina Nishio Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Akiko Tanabe Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Risa Maruoka Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Kiyoko Nakamura Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Masaaki Takai Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Tatsuharu Sekijima Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Satoshi Tunetoh Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Yoshito Terai Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Masahide Ohmichi Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Introduction Cancer survivors are living longer after the initial diagnosis of cancer due to earlier diagnosis and improved cancer treatments. Epithelial ovarian cancer (OC), uterine endometrial cancer (EC), and cervical cancer (CC) are major

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Victoria Chatzimavridou-Grigoriadou Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, UK
Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK

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Lisa H Barraclough Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, UK
Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK

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Rohit Kochhar Department of Clinical Oncology, Christie Hospital NHS Foundation Trust, Manchester, UK

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Lucy Buckley Department of Radiology, Christie Hospital NHS Foundation Trust, Manchester, UK

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Nooreen Alam Department of Radiotherapy, Christie Hospital NHS Foundation Trust, Manchester, UK

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Claire E Higham Department of Endocrinology, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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comparing the aBMD of postmenopausal women with cervical cancer treated with concurrent chemoradiotherapy and matched controls with history of hysterectomy for leiomyomas, BMD of L4, total hip (left) and greater trochanter was significantly lower in the

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Katherine A Bolton Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia

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Kelly A Avery-Kiejda Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia

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Elizabeth G Holliday Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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John Attia Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Nikola A Bowden Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia

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Rodney J Scott Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, University Drive, Newcastle, New South Wales, Australia

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cancer, a recent study found significant differences in the repeat length between some types of cervical cancer and control groups ( 41 ), whereas no association was found with cervical cancer risk in an earlier study ( 42 ). These discrepancies may

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Weiwei Liang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Yilin Zhang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

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Yan Guo Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Pengyuan Zhang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Jiewen Jin Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Hongyu Guan Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Yanbing Li Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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cancers, and it may function as a potential oncogene or tumor suppressor ( 9 ). Several studies suggest that FLNA expression is upregulated and plays a promotional role in a variety of cancers, such as cervical cancer ( 10 ) and pancreatic cancer ( 11

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Ling Zhou Cangzhou Central Hospital, Cangzhou, Hebei, China

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Ruixue Zhang Cangzhou Central Hospital, Cangzhou, Hebei, China

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Shuangyan Yang Cangzhou Central Hospital, Cangzhou, Hebei, China

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Yaguang Zhang Cangzhou Central Hospital, Cangzhou, Hebei, China

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Dandan Shi Cangzhou Central Hospital, Cangzhou, Hebei, China

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( 1 , 2 , 3 ), therefore AS-IV has been widely used to treat hypertension ( 4 , 5 ), cardiovascular diseases ( 6 , 7 ), breast cancer ( 8 ) and cervical cancer ( 9 ). Moreover, numerous publications have demonstrated that AS-IV could protect

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Daiki Kobayashi Division of General Internal Medicine Department of Medicine, St. Luke’s International Hospital, Tokyo, Japan
Department of Epidemiology St. Luke’s International University Graduate School of Public Health, Tokyo, Japan
Fujita Health University Toyoake, Japan

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Nagato Kuriyama Department of Epidemiology for Community Health and Medicine Kyoto Prefectural University of Medicine, Kyoto, Japan

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Keita Hirano Department of Nephrology Kyoto University Graduate School of Medicine, Kyoto, Japan

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Osamu Takahashi Division of General Internal Medicine Department of Medicine, St. Luke’s International Hospital, Tokyo, Japan
Department of Epidemiology St. Luke’s International University Graduate School of Public Health, Tokyo, Japan

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Hiroshi Noto Department of Endocrinology St. Luke’s International Hospital, Tokyo, Japan

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.7 Pancreatic cancer 8 2.1 Kidney cancer 7 1.9 Lymphoma 6 1.6 Skin cancer 6 1.6 Bile duct and gallbladder cancer 4 1.1 Leukemia 4 1.1 Cervical cancer 3 0.8 Mediastinal neoplasm 2 0

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Marra Jai Aghajani Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia

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Tara Laurine Roberts Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia

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Tao Yang School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia

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Charles Eugenio McCafferty Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia

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Nicole J Caixeiro Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Centre for Oncology Education and Research Translation (CONCERT), Liverpool, New South Wales, Australia

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Paul DeSouza Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia

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Navin Niles Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

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of patients with cervical cancer, patients with cervical intraepithelial neoplasia (CIN) and healthy controls ( 31 ). Moreover, higher levels of sPD-L1 were associated with differentiated cancer, an absence of lymph node metastasis and improved

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Zhandong Lei Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China
Department of Anatomy, Shanxi Medical University, Taiyuan, China

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Yunfei Chen Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Jin Wang Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Yan Zhang Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Wenjuan Shi Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Xuejiao Wang Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Dehai Xing Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Dongxue Li Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Xiangying Jiao Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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). Numerous studies have demonstrated that Txnip is downregulated in various cancers and human cancer cells, such as breast cancer, stomach cancer, lung cancer, colon cancer, cervical cancer, gastrointestinal cancer, prostate cancer, cutaneous T

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Zeming Liu Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Di Hu Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Yihui Huang Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Sichao Chen Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Wen Zeng Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China

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Ling Zhou Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Wei Zhou Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Min Wang Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Haifeng Feng Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Wei Wei Department of Pediatrics, St John Hospital and Medical Center, Detroit, Michigan, USA

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Chao Zhang Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Danyang Chen Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Liang Guo Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Schmid MP Franckena M Kirchheiner K Sturdza A Georg P Dorr W Potter R. Distant metastasis in patients with cervical cancer after primary radiotherapy with or without chemotherapy and image guided adaptive brachytherapy . Gynecologic Oncology 2014

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E R Polina Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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F M Oliveira Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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R C Sbruzzi Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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D Crispim Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

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L H Canani Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

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K G Santos Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil
Cardiovascular Research Laboratory, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

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polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population . Gene 2016 109 – 114 . ( https://doi.org/10.1016/j.gene.2016.10.002 ) 46 Yang X Peng J Pang J Wan W Chen L . A functional

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