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pathologically from those in non-diabetic individuals ( 3 , 4 ). Arterial plaque formation can be influenced by a high glucose environment, putting diabetics with concurrent carotid atherosclerosis (CA) at greater risk of cardiovascular events compared to the
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Background:
Evidence has demonstrated that visceral fat area (VFA) and subcutaneous fat area (SFA) had different influences on cardiovascular disease (CVD) risk in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the relationship between the visceral fat area (VFA) to subcutaneous fat area (SFA) ratio (V/S) and carotid atherosclerosis (CAS) in patients with T2DM.
Methods:
From January 2018 to May 2023, 1,838 patients with T2DM admitted to the National Metabolic Management Centre in our hospital were assigned to two groups based on comorbid CAS. Dual bioelectrical impedance analysis was used to measure the VAF and SFA, and the V/S was calculated. Patient characteristics and serum biochemical indices were compared between groups. Factors influencing comorbid CAS were determined, and correlations between V/S and other clinical indices were analyzed.
Results:
The group with comorbid CAS included 858 individuals and 980 without comorbid CAS. Those with comorbid CAS were older and had a longer disease duration, more significant systolic blood pressure, and greater V/S. The proportions of patients with comorbid hypertension increased significantly with the V/S ratio. The V/S ratio positively correlated with triglyceride (TG), low-density lipoprotein cholesterol levels, and waist circumference. According to binary logistic regression analysis, V/S was an independent risk factor for CAS.
Conclusion:
Elevated V/S is an independent risk factor for CAS in patients with T2DM.
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correlated with carotid atherosclerosis. In animal and in vitro studies, FGF21 has been shown to improve lipid distribution and inhibit key processes of the pathogenesis of atherosclerosis. It acts on the cardiovascular system through adiponectin
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Vascular Laboratory, Cairo University, Cairo, Egypt
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. Pediatric Diabetes 2016 17 458 – 465 . ( https://doi.org/10.1111/pedi.12303 ) 14 Irace C Carallo C Scavelli FB De Franceschi MS Esposito T Tripolino C Gnasso A . Markers of insulin resistance and carotid atherosclerosis. A comparison of the
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Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
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Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
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Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
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subclinical carotid atherosclerosis: the Northern Manhattan study . Stroke 2011 42 2240 – 2245 . ( doi:10.1161/STROKEAHA.110.608539 ). 15 Giallauria F Milaneschi Y Tanaka T Maggio M Canepa M Elango P Vigorito C Lakatta EG Ferrucci L
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association with carotid atherosclerosis and insulin resistance . Gynecological Endocrinology 2012 28 111 – 114 . ( https://doi.org/10.3109/09513590.2011.589929 ) 10.3109/09513590.2011.589929 33 Conway GS Agrawal R Betteridge DJ Jacobs HS. Risk
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Atherosclerosis and Thrombosis 2019 26 573 – 581 . ( https://doi.org/10.5551/jat.46508 ) 35 Niki H Kishimoto Y Saita E Ohmori R Kondo K Momiyama Y . Plasma betatrophin levels and carotid atherosclerosis . Disease Markers 2019 2019 4214650 . ( https
