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Katica Bajuk Studen and Marija Pfeifer

disorders in PCOS There is also a growing body of evidence suggesting that sleep disturbances including obstructive sleep apnea (OSA) and excessive daytime sleepiness can be added to the list of cardiometabolic risk factors in PCOS with link between the

Open access

Line K Johnson, Kirsten B Holven, Njord Nordstrand, Jan R Mellembakken, Tom Tanbo and Jøran Hjelmesæth

a lower prevalence of cardiometabolic risk factors including MS, cardiovascular inflammation and obesity (15) . Additionally, fiber intake improves gastrointestinal function and may prevent development of colorectal cancer (16) . Fiber intake from

Open access

Angelo Maria Patti, Kalliopi Pafili, Nikolaos Papanas and Manfredi Rizzo

( 19 , 20 , 21 ), and family history of CV risk is closely related to future CVD ( 22 , 23 ). Is there a synergistic effect of GDM and HDP on postpartum cardiometabolic risk? It has been reported that there is a significant link between

Open access

Ling-Jun Li, Izzuddin M Aris, Lin Lin Su, Yap Seng Chong, Tien Yin Wong, Kok Hian Tan and Jie Jin Wang


The cumulative effect of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on postpartum cardio-metabolic diseases is equivocal. We aimed to assess the associations of GDM and HDP’s individual and synergic contribution to risks of postpartum cardio-metabolic diseases (metabolic syndrome (MetS), abnormal glucose metabolism and hypertension (HTN)).


Of participants from a Singapore birth cohort, 276 mothers attending the 5-year postpartum visit were included in this study. During this visit, we collected mothers’ history of GDM and HDP in all live births in a chronicle sequence and assessed the cardio-metabolic risks based on blood pressure, anthropometry and a panel of serum biomarkers. We diagnosed MetS, abnormal glucose metabolism and HTN according to Adult Treatment Panel III 2000 and World Health Organization guidelines.


Of 276 mothers, 157 (56.9%) had histories of GDM while 23 (8.3%) had histories of HDP. After full adjustment, we found associations of GDM episodes with postpartum abnormal glucose metabolism (single episode: relative risk (RR) 2.9 (95% CI: 1.7, 4.8); recurrent episodes (≥2): RR = 3.8 (2.1–6.8)). Also, we found association between histories of HDP and HTN (RR = 3.6 (1.5, 8.6)). Having either (RR 2.6 (1.7–3.9)) or both gestational complications (RR 2.7 (1.6–4.9)) was associated with similar risk of postpartum cardio-metabolic disease.


Mothers with GDM or HDP had a threefold increased risk of postpartum abnormal glucose metabolism or HTN, respectively. Having both GDM and HDP during past pregnancies was not associated with additional risk of postpartum cardio-metabolic diseases beyond that associated with either complication alone.

Open access

Shenglong Le, Leiting Xu, Moritz Schumann, Na Wu, Timo Törmäkangas, Markku Alén, Sulin Cheng and Petri Wiklund

might be an important regulator of puberty and a biomarker for cardiometabolic risk ( 3 ). However, confounding or reverse causation, may explain part of the association. Indeed, there may be a bidirectional relationship between SHBG, insulin resistance

Open access

Eliana Piantanida, Daniela Gallo, Giovanni Veronesi, Eugenia Dozio, Eugenia Trotti, Adriana Lai, Silvia Ippolito, Jessica Sabatino, Maria Laura Tanda, Antonio Toniolo, Marco Ferrario and Luigi Bartalena

supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: a randomized controlled double blind clinical trial . Journal of Endocrinology Investigation 2016 39 1303 – 1313 . ( doi:10.1007/s40618-016-0507-8 ) 10.1007/s40618

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Andrea V Haas, Paul N Hopkins, Nancy J Brown, Luminita H Pojoga, Jonathan S Williams, Gail K Adler and Gordon H Williams

, individuals with incidentally discovered adrenal masses and biochemical work-up consistent with subclinical Cushing’s syndrome also have increased cardiometabolic risk ( 2 , 3 , 4 , 5 , 6 ). Even among individuals with biochemical work-up consistent with

Open access

Jing Wang, Leishen Wang, Huikun Liu, Shuang Zhang, Junhong Leng, Weiqin Li, Tao Zhang, Nan Li, Wei Li, Andrea A Baccarelli, Lifang Hou and Gang Hu

( Supplement 2 ) S169 – S174 . ( ) 10 Tam WH Ma RCW Ozaki R Li AM Chan MHM Yuen LY Lao TTH Yang X Ho CS Tutino GE , et al . In utero exposure to maternal hyperglycemia increases childhood cardiometabolic risk in offspring

Open access

Søs Dragsbæk Larsen, Christine Dalgård, Mathilde Egelund Christensen, Sine Lykkedegn, Louise Bjørkholt Andersen, Marianne Andersen, Dorte Glintborg and Henrik Thybo Christesen

.1007/s10654-013-9790-2 ) 5 Dolinsky DH Armstrong S Mangarelli C Kemper AR. The association between vitamin D and cardiometabolic risk factors in children: a systematic review . Clinical Pediatrics 2013 52 210 – 223 . (

Open access

Thozhukat Sathyapalan, Anne-Marie Coady, Eric S Kilpatrick and Stephen L Atkin

10 CD008565 . ( doi:10.1002/14651858.CD008565.pub2 ) 14 Yildiz BO Bozdag G Yapici Z Esinler I Yarali H. Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria . Human