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M L M Barreto-Chaves, N Senger, M R Fevereiro, A C Parletta and A P C Takano

uptake by the sarcoplasmic reticulum during diastole. However, the long-term effects of T3 may result in cardiac hypertrophy as a consequence of dysfunction, also classified as pathological hypertrophy, which leads to cardiac remodeling and heart failure

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Madalena von Hafe, João Sergio Neves, Catarina Vale, Marta Borges-Canha and Adelino Leite-Moreira

contribute to adverse cardiac remodeling with possible evolution to heart failure. The pathophysiology of IRI is complex; however, recent evidence suggests that mitochondrial dysfunction may be one of the major mechanisms of IRI ( 99 ). The incidence of post

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Susanna Cirera, Sophia G Moesgaard, Nora E Zois, Nathja Ravn, Jens P Goetze, Signe E Cremer, Tom Teerlink, Páll S Leifsson, Jesper L Honge, J Michael Hasenkam and Lisbeth H Olsen

extensive cardiac remodeling. Future studies including more pigs developing sMR over a longer period of time are needed to clarify this point. Hereby, we also investigated the expression profile of relevant microRNAs primarily associated with cardiac

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Satoshi Higuchi, Hideki Ota, Takuya Ueda, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh and Kei Takase

( 3 , 4 , 5 , 6 ). The excess catecholamines and their metabolites have direct toxic as well as receptor-mediated effects on myocardial tissue ( 7 , 8 ). Progressive cardiac injury leads to cardiac remodeling and decreased cardiac function

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Tsuneo Ogawa and Adolfo J de Bold

hypertension and renal failure. Several findings suggest that ET1 produced locally in the heart may have hypertrophic and fibrotic effects, thus contributing to cardiac remodelling (181, 182, 183) . Conclusion The heart as an endocrine organ owes its

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Frans H H Leenen, Mordecai P Blaustein and John M Hamlyn

comparable beneficial effects on cardiac remodeling as well as dysfunction suggesting that CNS MR blockade by chronic oral treatment with spironolactone plays an important role ( 126 ). On the other hand, although central and systemic treatment with the AT 1

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Hugo R Ramos, Andreas L Birkenfeld and Adolfo J de Bold

obesity promotes hypertension partly through reduced vascular and renal NP responses as well as through impaired NP-mediated RAAS inhibition. Second, cNP also have beneficial actions on cardiac remodelling in essential hypertension, reducing left