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Mieke Van Hemelrijck, Thurkaa Shanmugalingam, Cecilia Bosco, Wahyu Wulaningsih and Sabine Rohrmann

Introduction Both insulin-like growth factor 1 (IGF1) and calcium metabolisms have been linked to chronic diseases such as cardiovascular disease and cancer (1, 2, 3, 4) . IGF1 is a polypeptide hormone implicated in cell differentiation

Open access

Ranganathan R Rao, Harpal S Randeva, Sailesh Sankaranarayanan, Murthy Narashima, Matthias Möhlig, Hisham Mehanna and Martin O Weickert

, 5) . Recent studies indicate that treatment of vitamin D deficiency may have the potential to reduce circulating PTH levels in patients with pHPT, without adverse effects on serum-adjusted calcium (adjCa) levels (3, 4, 5) . Data regarding the

Open access

Laura J Reid, Bala Muthukrishnan, Dilip Patel, Mike S Crane, Murat Akyol, Andrew Thomson, Jonathan R Seckl and Fraser W Gibb

intervention is appropriate (a decision largely based on age, serum calcium and presence of bone and/or renal complications) ( 6 ). Only when a decision to pursue surgical cure is made should neck imaging be performed. However, the optimal imaging modality in

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Agnès Linglart, Martin Biosse-Duplan, Karine Briot, Catherine Chaussain, Laure Esterle, Séverine Guillaume-Czitrom, Peter Kamenicky, Jerome Nevoux, Dominique Prié, Anya Rothenbuhler, Philippe Wicart and Pol Harvengt

adequately suppressed, and 1,25-diOH-vitamin D production and absorption of calcium through the gut and urinary calcium excretion are consequently enhanced. Besides acquired disorders like tumors or drug toxicity, most conditions leading to phosphate wasting

Open access

A Chinoy, M Skae, A Babiker, D Kendall, M Z Mughal and R Padidela

absorption of oral calcium (Ca) from the intestine. PTH also mobilises Ca from the bone (by increasing the number and activity of osteoclasts to encourage bone resorption) to maintain serum Ca concentration. PTH also regulates serum phosphate. HPT is

Open access

K Amrein, A Papinutti, E Mathew, G Vila and D Parekh

A short history of vitamin D in critical care Only 10 years ago, a potential link between acute illness and vitamin D, which is well known for its role in calcium and bone homeostasis, was regarded as quite absurd – how could this hormone be

Open access

Ursula M M Costa, Carla R P Oliveira, Roberto Salvatori, José A S Barreto-Filho, Viviane C Campos, Francielle T Oliveira, Ivina E S Rocha, Joselina L M Oliveira, Wersley A Silva and Manuel H Aguiar-Oliveira

, 20, 21) . Measurement of coronary artery calcium by multi-detector tomography has been shown to predict the risk of clinical coronary disease (22, 23, 24, 25) . This study tested whether subclinical atherosclerosis is accelerated in these IGHD

Open access

E Vignali, F Cetani, S Chiavistelli, A Meola, F Saponaro, R Centoni, L Cianferotti and C Marcocci

Introduction During the past 10–20 years several investigators have noticed that there are patients with elevated serum parathyroid hormone (PTH) levels associated with consistently normal serum calcium concentration and no other causes of secondary

Open access

Maxime Duval, Kalyane Bach-Ngohou, Damien Masson, Camille Guimard, Philippe Le Conte and David Trewick

the risk of sudden cardiac arrest (SCA) in the community ( 5 ). Calcium is a bivalent cation that is essential for a number of physiological processes that include neuromuscular activity, endocrine and exocrine secretion, coagulation, immunity and

Open access

Stan Ursem, Vito Francic, Martin Keppel, Verena Schwetz, Christian Trummer, Marlene Pandis, Felix Aberer, Martin R Grübler, Nicolas D Verheyen, Winfried März, Andreas Tomaschitz, Stefan Pilz, Barbara Obermayer-Pietsch and Annemieke C Heijboer

Introduction Parathyroid hormone (PTH) plays a critical role in maintaining adequate serum calcium homeostasis. It increases serum calcium by stimulating bone resorption, promoting phosphate excretion, converting vitamin D to its active form