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Effects of low-dose oral micronised progesterone on sleep, psychological distress, and breast development in transgender individuals undergoing feminising hormone therapy: a prospective controlled study

Brendan J Nolan, Aviva S Frydman, Shalem Y Leemaqz, Meg Carroll, Mathis Grossmann, Jeffrey D Zajac, and Ada S Cheung

more rapid feminisation with greater testosterone suppression and enhanced breast development ( 2 ), however, others raise concerns regarding breast cancer and cardiovascular disease risk with the use of progestins ( 3 ). Due to a lack of evidence

Open access

Urinary estrogen metabolites and breast cancer risk in Chinese population

Xiaomin Li, Ling Fang, Hongjiang Li, and Xiaoqin Yang

Introduction Breast cancer is a malignant tumor that occurs in the mammary gland. It is the leading female malignant tumor, posing a major threat to women’s health globally. However, the incidence of breast cancer worldwide, including China

Open access

Phase I trial of the androgen receptor modulator CR1447 in breast cancer patients

Martin Zweifel, Beat Thürlimann, Salome Riniker, Patrik Weder, Roger von Moos, Olivia Pagani, Martin Bigler, Karin M Rothgiesser, Christiane Pilop, Hanne Hawle, Peter Brauchli, Coya Tapia, Wolfgang Schoenfeld, Cristiana Sessa, and for the Swiss Group for Clinical Cancer Research (SAKK)

Introduction For the treatment of breast cancer (BC), testosterone was already used extensively between the 1930s and 1960s with anecdotal tumour responses (especially in bone metastases) seen in up to 20% of treated women ( 1 , 2 , 3 , 4

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pS6K1 as an efficacy marker of GnRH agonist with premenopausal breast cancer

Chan Sub Park, Jihye Choi, Min-Ki Seong, Sung-Eun Hong, Jae-Sung Kim, In-Chul Park, Hyesil Seol, Woo Chul Noh, and Hyun-Ah Kim

Introduction Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor (HR)-positive breast cancer. Although estradiol is produced mainly by the ovary in premenopausal women, the adrenal gland and adipocytes are also

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Risk of primary brain tumour after breast cancer

Anne M Drewes, Maria E Møller, Rasmus Hertzum-Larsen, Gerda Engholm, and Hans H Storm

Introduction Survival after breast cancer has improved substantially worldwide over recent decades. Due to the high and increasing incidence of breast cancer in the developed world, the survivor cohort is big, and the possibility of long

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Serum levels of polyamine synthesis enzymes increase in diabetic patients with breast cancer

V Kenan Çelik, Sercan Kapancık, Turgut Kaçan, Selen Baloglu Kaçan, Serkan Kapancık, and Hasan Kılıçgün

11 adults has diabetes and this ratio will be increased 1/10 in 2040. Type II diabetes, the most common form of diabetes, increases with changing cultural and social changes. Many years ago, breast cancer was found to be more common in diabetic

Open access

Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk

Piera Rizzolo, Valentina Silvestri, Virginia Valentini, Veronica Zelli, Agostino Bucalo, Ines Zanna, Simonetta Bianchi, Maria Grazia Tibiletti, Antonio Russo, Liliana Varesco, Gianluca Tedaldi, Bernardo Bonanni, Jacopo Azzollini, Siranoush Manoukian, Anna Coppa, Giuseppe Giannini, Laura Cortesi, Alessandra Viel, Marco Montagna, Paolo Peterlongo, Paolo Radice, Domenico Palli, and Laura Ottini

Introduction Male breast cancer (MBC) is a rare disease, representing about 1% of all breast cancers (BCs) and less than 1% of all cancers in men ( 1 ). Germline pathogenic variants in BC genes, particularly BRCA1 , BRCA2 and PALB2 genes

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BRIP1 overexpression is correlated with clinical features and survival outcome of luminal breast cancer subtypes

Ishita Gupta, Allal Ouhtit, Adil Al-Ajmi, Syed Gauhar A Rizvi, Hamad Al-Riyami, Marwa Al-Riyami, and Yahya Tamimi

Introduction Breast cancer is the most common among women, affecting 25% of female population worldwide and more than a million new cases are diagnosed every year ( 1 ). Environmental components are considered serious risk factors, whereas

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Leptin induces cell migration and invasion in a FAK-Src-dependent manner in breast cancer cells

Juan Carlos Juárez-Cruz, Miriam Daniela Zuñiga-Eulogio, Monserrat Olea-Flores, Eduardo Castañeda-Saucedo, Miguel Ángel Mendoza-Catalán, Carlos Ortuño-Pineda, Ma Elena Moreno-Godínez, Sócrates Villegas-Comonfort, Teresita Padilla-Benavides, and Napoleón Navarro-Tito

Introduction Breast cancer is the most common invasive neoplasia and the second-leading cause of cancer-related death in women worldwide. Over 2,000,000 cases are diagnosed annually worldwide, which represents the highest incidence of cancer

Open access

Therapeutic advances in hormone-dependent cancers: focus on prostate, breast and ovarian cancers

Michael Ulm, Arvind V Ramesh, Keely M McNamara, Suriyan Ponnusamy, Hironobu Sasano, and Ramesh Narayanan

Introduction As a class, hormone-dependent cancers, including cancers of the breast, prostate and ovaries, contribute to the majority of cancer incidences in the United States and around the world. Over 400,000 men and women were affected by