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Gareth Leng

-specific expression of their receptors. By contrast, neuroscience is the study of the brain, and particularly of neurones that release neurotransmitters at synapses with effects tightly localised in space and time, constrained by mechanisms of rapid reuptake and

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Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather M Stapleton and Heather B Patisaul

similarities with known neurotoxicants and endocrine-disrupting chemicals (EDCs), including PBDEs ( 9 ) and organophosphate pesticides ( 10 ), have raised concerns regarding possible health impacts, especially on the developing brain. Because we have found

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Bilal B Mughal, Jean-Baptiste Fini and Barbara A Demeneix

Introduction Thyroid hormone (TH) is essential for normal brain development where it influences, during specific temporal windows, neurogenesis, neuronal migration, neuronal and glial cell differentiation, myelination and synaptogenesis. These

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Carolina Inda, Natalia G Armando, Paula A dos Santos Claro and Susana Silberstein

are essential to the stress response driving both basal and stress-induced hypothalamic–pituitary–adrenal axis (HPA) activation. Besides the hypothalamus, CRH is widely distributed in extrahypothalamic circuits of the brain where it functions as a

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H A Booij, W D C Gaykema, K A J Kuijpers, M J M Pouwels and H M den Hertog

articles on PD after aneurysmatic subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) and the association with fatigue, since the mechanism of PD in these other acute acquired brain injuries might be similar as in stroke. A better understanding

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Rachel K Rowe, Benjamin M Rumney, Hazel G May, Paska Permana, P David Adelson, S Mitchell Harman, Jonathan Lifshitz and Theresa C Thomas

Introduction Traumatic brain injury (TBI) is a major cause of death and disability throughout the world with few pharmacological treatments for the individuals who suffer from lifelong neurological symptoms associated with TBI. Brain injuries

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Frans H H Leenen, Mordecai P Blaustein and John M Hamlyn

reflexes send afferent information to the brain and control sympathetic nerve traffic to arteries and veins, heart and kidneys. According to the Guytonian view of the circulation, these reflexes reset and the CNS and sympathetic activity have only limited

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Laura van Iersel, Sarah C Clement, Antoinette Y N Schouten-van Meeteren, Annemieke M Boot, Hedi L Claahsen-van der Grinten, Bernd Granzen, K Sen Han, Geert O Janssens, Erna M Michiels, A S Paul van Trotsenburg, W Peter Vandertop, Dannis G van Vuurden, Hubert N Caron, Leontien C M Kremer and Hanneke M van Santen

Introduction Childhood brain tumor survivors (CBTS) have an increased risk of developing central hypothyroidism due to damage of the hypothalamic–pituitary (HP) region, especially after exposure to cranial radiotherapy (cRT) ( 1 , 2 ). The

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Joana Simões-Pereira, Daniel Macedo and Maria João Bugalho

. Those patients not eligible for surgery may undergo stereotaxic radiosurgery (SRS) or whole-brain radiotherapy (WBR). RAI can be considered for iodine-avid CNS metastases, under glucocorticoid therapy to minimize the TSH-induced effects and the

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Gavin P Vinson and Caroline H Brennan

also in protection against it. The hypophyseal–pituitary–adrenal axis in the brain and addiction In relation to addiction, far more attention has been paid to hypophyseal–pituitary–adrenal (HPA) components in the brain than to the systemic (i.e. blood