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Katherine Van Loon, Li Zhang, Jennifer Keiser, Cendy Carrasco, Katherine Glass, Maria-Teresa Ramirez, Sarah Bobiak, Eric K Nakakura, Alan P Venook, Manisha H Shah, and Emily K Bergsland

(2) . Historically, bone metastases from NETs were considered to be extremely rare (3, 4) . As few as 50 case reports were identified in a recently published literature review on skeletal metastases from carcinoid tumors (5) . In a series of 145

Open access

Matteo Scopel, Eugenio De Carlo, Francesca Bergamo, Sabina Murgioni, Riccardo Carandina, Anna Rita Cervino, Marta Burei, Federica Vianello, Vittorina Zagonel, Matteo Fassan, and Roberto Vettor

always been considered a rare and late event. To date, thanks to the improvement of therapies, which has lengthened the life expectancy of NET patients, and imaging techniques, in particular PET with 68 Ga-SSA, the amount of diagnosis of bone metastases

Open access

Jiaxin Luo, Weili Yin, Qiuxia Lin, Juqing Wu, Pan Chen, Yuanna Ling, Jing Wang, Zhen Li, Liqin Pan, Yanying Chen, Wei Ouyang, and Huijuan Feng

detection and appropriate treatment might improve the survival rate and quality of life of patients with DTC bone metastases ( 10 ). However, there is no standardized treatment regimen for these patients. At present, the main treatment modalities include

Open access

Sondra O’Callaghan and Hanford Yau

effect on survival; this has been observed over time ( 4 , 6 ). Despite advances in therapeutics, survival after diagnosis of MAH has not changed over the decades. In the 1980s, patients with bone metastases from breast cancer were observed to survive

Open access

Emma Jernberg, Anders Bergh, and Pernilla Wikström

-V/ARwt heterodimers form in parallel and have the potential to regulate different sets of target genes ( 75 ). AR-Vs may transcribe canonically androgen-regulated genes or a unique subset of genes or possibly both. In clinical bone metastases, we found high AR-V7

Open access

Samira M Sadowski, Emanuel Christ, Benoit Bédat, Attila Kollár, Wolfram Karenovics, Aurel Perren, Frédéric Triponez, and on behalf of the SwissNET registry

diagnosed with liver and 3 with bone metastases at diagnosis. As for laboratory workup, data in the registry were incomplete. In 20 patients, median Chromogranin A was 60.8 (20–1773) µg/L, for a normal upper limit of 85 µg/L. In 9 patients, mean Neuron

Open access

Athanasios D Anastasilakis, Marina Tsoli, Gregory Kaltsas, and Polyzois Makras

successfully used as a therapeutic and preventive treatment strategy in management of patients with bone metastases from various tumors ( 62 ). Their beneficial effect in LCH bone lesions was first reported in 1989 when clodronate was used to treat multifocal

Open access

Joana Simões-Pereira, Daniel Macedo, and Maria João Bugalho

metastases (encephalic parenchyma involvement and/or leptomeningeal carcinomatosis) from this tumor were considered as inclusion criteria. Patients with coexisting malignant neoplasms and/or CNS involvement due to skull bone metastases were excluded from

Open access

Martin Zweifel, Beat Thürlimann, Salome Riniker, Patrik Weder, Roger von Moos, Olivia Pagani, Martin Bigler, Karin M Rothgiesser, Christiane Pilop, Hanne Hawle, Peter Brauchli, Coya Tapia, Wolfgang Schoenfeld, Cristiana Sessa, and for the Swiss Group for Clinical Cancer Research (SAKK)

Introduction For the treatment of breast cancer (BC), testosterone was already used extensively between the 1930s and 1960s with anecdotal tumour responses (especially in bone metastases) seen in up to 20% of treated women ( 1 , 2 , 3 , 4

Open access

David C Llewellyn, Rajaventhan Srirajaskanthan, Royce P Vincent, Catherine Guy, Eftychia E Drakou, Simon J B Aylwin, Ashley B Grossman, John K Ramage, and Georgios K Dimitriadis

cancer. 52% had raised CTN 7 Hansen et al . (27) Denmark All SCLC Prospective Not mentioned 74 Up to 55000 Not mentioned Bone metastases have no influence on CTN concentrations. Results resemble concentrations seen in MTC. 2