Katherine Van Loon
Katherine Van Loon
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Li Zhang
Li Zhang
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Jennifer Keiser
Jennifer Keiser
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Cendy Carrasco
Cendy Carrasco
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Katherine Glass
Katherine Glass
The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA
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Maria-Teresa Ramirez
Maria-Teresa Ramirez
The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA
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Sarah Bobiak
Sarah Bobiak
The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA
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Eric K Nakakura
Eric K Nakakura
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Alan P Venook
Alan P Venook
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Manisha H Shah
Manisha H Shah
The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA
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Emily K Bergsland
Emily K Bergsland
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(2) . Historically, bone metastases from NETs were considered to be extremely rare (3, 4) . As few as 50 case reports were identified in a recently published literature review on skeletal metastases from carcinoid tumors (5) . In a series of 145
Matteo Scopel
Matteo Scopel
Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy
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Eugenio De Carlo
Eugenio De Carlo
Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy
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Francesca Bergamo
Francesca Bergamo
Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
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Sabina Murgioni
Sabina Murgioni
Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
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Riccardo Carandina
Riccardo Carandina
Radiodiagnostic Unit, University Hospital of Padua, Padua, Italy
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Anna Rita Cervino
Anna Rita Cervino
Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy
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Marta Burei
Marta Burei
Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy
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Federica Vianello
Federica Vianello
Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy
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Vittorina Zagonel
Vittorina Zagonel
Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
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Matteo Fassan
Matteo Fassan
Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Roberto Vettor
Roberto Vettor
Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy
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always been considered a rare and late event. To date, thanks to the improvement of therapies, which has lengthened the life expectancy of NET patients, and imaging techniques, in particular PET with 68 Ga-SSA, the amount of diagnosis of bone metastases
Jiaxin Luo
Jiaxin Luo
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Weili Yin
Weili Yin
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Qiuxia Lin
Qiuxia Lin
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
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Juqing Wu
Juqing Wu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Pan Chen
Pan Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yuanna Ling
Yuanna Ling
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Jing Wang
Jing Wang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Zhen Li
Zhen Li
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Liqin Pan
Liqin Pan
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yanying Chen
Yanying Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Wei Ouyang
Wei Ouyang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Huijuan Feng
Huijuan Feng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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detection and appropriate treatment might improve the survival rate and quality of life of patients with DTC bone metastases ( 10 ). However, there is no standardized treatment regimen for these patients. At present, the main treatment modalities include
Sondra O’Callaghan
Sondra O’Callaghan
Endocrinology, Diabetes & Metabolism, Orlando VA Healthcare System, Orlando, Florida, USA
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Hanford Yau
Hanford Yau
Endocrinology, Diabetes & Metabolism, Orlando VA Healthcare System, Orlando, Florida, USA
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effect on survival; this has been observed over time ( 4 , 6 ). Despite advances in therapeutics, survival after diagnosis of MAH has not changed over the decades. In the 1980s, patients with bone metastases from breast cancer were observed to survive
Emma Jernberg
Emma Jernberg
Department of Medical biosciences, Umeå University, Umeå, Sweden
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Anders Bergh
Anders Bergh
Department of Medical biosciences, Umeå University, Umeå, Sweden
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Pernilla Wikström
Pernilla Wikström
Department of Medical biosciences, Umeå University, Umeå, Sweden
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-V/ARwt heterodimers form in parallel and have the potential to regulate different sets of target genes ( 75 ). AR-Vs may transcribe canonically androgen-regulated genes or a unique subset of genes or possibly both. In clinical bone metastases, we found high AR-V7
Samira M Sadowski
Samira M Sadowski
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Emanuel Christ
Emanuel Christ
Department of Endocrinology, Diabetes and Metabolism, University Hospital of Basel, Basel, Switzerland
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Benoit Bédat
Benoit Bédat
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Attila Kollár
Attila Kollár
Department of Medical Oncology, Inselspital, University of Bern, Bern, Switzerland
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Wolfram Karenovics
Wolfram Karenovics
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Aurel Perren
Aurel Perren
Institute of Pathology, University of Bern, Bern, Switzerland
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Frédéric Triponez
Frédéric Triponez
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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on behalf of the SwissNET registry
on behalf of the SwissNET registry
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diagnosed with liver and 3 with bone metastases at diagnosis. As for laboratory workup, data in the registry were incomplete. In 20 patients, median Chromogranin A was 60.8 (20–1773) µg/L, for a normal upper limit of 85 µg/L. In 9 patients, mean Neuron
Athanasios D Anastasilakis
Athanasios D Anastasilakis
Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece
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Marina Tsoli
Marina Tsoli
1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Gregory Kaltsas
Gregory Kaltsas
1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Polyzois Makras
Polyzois Makras
Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, Athens, Greece
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successfully used as a therapeutic and preventive treatment strategy in management of patients with bone metastases from various tumors ( 62 ). Their beneficial effect in LCH bone lesions was first reported in 1989 when clodronate was used to treat multifocal
Martin Zweifel
Martin Zweifel
Department of Medical Oncology, University Hospital Bern, Bern, Switzerland
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Beat Thürlimann
Beat Thürlimann
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Salome Riniker
Salome Riniker
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Patrik Weder
Patrik Weder
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Roger von Moos
Roger von Moos
Kantonsspital Graubünden, Chur, Switzerland
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Olivia Pagani
Olivia Pagani
Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
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Martin Bigler
Martin Bigler
SAKK Coordinating Centre, Bern, Switzerland
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Karin M Rothgiesser
Karin M Rothgiesser
SAKK Coordinating Centre, Bern, Switzerland
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Christiane Pilop
Christiane Pilop
SAKK Coordinating Centre, Bern, Switzerland
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Hanne Hawle
Hanne Hawle
SAKK Coordinating Centre, Bern, Switzerland
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Peter Brauchli
Peter Brauchli
SAKK Coordinating Centre, Bern, Switzerland
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Coya Tapia
Coya Tapia
Institute of Pathology, University of Bern, Bern, Switzerland
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Wolfgang Schoenfeld
Wolfgang Schoenfeld
CURADIS GmbH, Erlangen, Germany
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Cristiana Sessa
Cristiana Sessa
Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
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for the Swiss Group for Clinical Cancer Research (SAKK)
for the Swiss Group for Clinical Cancer Research (SAKK)
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Introduction For the treatment of breast cancer (BC), testosterone was already used extensively between the 1930s and 1960s with anecdotal tumour responses (especially in bone metastases) seen in up to 20% of treated women ( 1 , 2 , 3 , 4
Joana Simões-Pereira
Joana Simões-Pereira
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal
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Daniel Macedo
Daniel Macedo
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal
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Maria João Bugalho
Maria João Bugalho
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal
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metastases (encephalic parenchyma involvement and/or leptomeningeal carcinomatosis) from this tumor were considered as inclusion criteria. Patients with coexisting malignant neoplasms and/or CNS involvement due to skull bone metastases were excluded from
Lauren E Henke
Lauren E Henke
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA
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John D Pfeifer
John D Pfeifer
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA
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Thomas J Baranski
Thomas J Baranski
Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA
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Todd DeWees
Todd DeWees
Division of Biomedical Statistics and Informatics, Mayo Clinic, Scottsdale, Arizona, USA
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Perry W Grigsby
Perry W Grigsby
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA
Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA
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Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA
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<0.001 Thyroid only 700 (54.2) 464 (48.6) 236 (70.0) <0.001 Thyroid and cervical LN 548 (42.4) 456 (47.8) 92 (27.3) <0.001 Lung metastases 38 (3.4) 29 (3.0) 9 (2.7) 0.735 Bone metastases 5 (0
