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Sebastião Freitas de Medeiros, Márcia Marly Winck Yamamoto, Matheus Antônio Souto de Medeiros, Bruna Barcelo Barbosa, José Maria Soares Junior and Edmund Chada Baracat


To verify whether aging can modify the clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS).

Material and methods

This observational cross-sectional study was conducted at the reproductive endocrinology clinics of Julio Muller University Hospital and Tropical Institute of Reproductive Medicine in Cuiabá, MT, Brazil, between 2003 and 2017. Both, 796 PCOS and 444 non-PCOS normal cycling women underwent the same examination. PCOS was diagnosed using the Rotterdam criteria as recommended for adolescent and adult subjects. Anthropometric, metabolic, and endocrinological modifications with aging were initially examined in the two groups: control and PCOS. Further analyses were performed after a 5-year age stratification of data throughout the reproductive period. All participants signed a consent form approved by the local ethical committee.


Biomarkers of adiposity were more remarkable in African descendant PCOS women. Body weight, waist/hip ratio, fat mass, and BMI were higher in PCOS women and tended to increase at all 5 age-strata, between ≤19 and 35 years of age. Serum androgen levels decreased with aging, markedly in PCOS subjects (P < 0.01 for all age-strata comparisons), but remained elevated when compared with the levels found in controls. Carbohydrate markers, triglycerides, and total cholesterol tended to increase over time in PCOS (P < 0.01 for all age-strata comparisons). Total cholesterol also tended to increase with age in non-PCOS women (P = 0.041).


The present study has shown that the advancing age influences many features of PCOS women. Biochemical hyperandrogenism, the core criterion recommended in the current systems to define the syndrome, showed statistically significant tendencies to decrease with aging progression but did not normalize. The use of age-adjusted features for the diagnosis of PCOS are recommended.

Open access

Elizabeth Yan Zhang and Bao-Ting Zhu

–5 days after pellet implantation, at which time the toxicity of estrogen treatment based on body weight change reaches peak level, the average plasma levels of free E 3 were found to be at 12.5 nM (21) , a level that is within the physiological range

Open access

Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou and Zubing Mei

. 4 ). Figure 4 Effects of incretin-based therapies on total daily insulin dose. Body weight change in T1DM patients with incretin-based therapy and subgroup analysis based on mean baseline BMI (≥28 kg/m 2 or <28 kg/m 2 ), incretin

Open access

Yali Cheng, Qiaoying Lv, Bingying Xie, Bingyi Yang, Weiwei Shan, Chengcheng Ning, Bing Li, Liying Xie, Chao Gu, Xuezhen Luo, Xiaojun Chen and Qin Zhu

findings indicated that sustained estrogen stimulation and high-fat diet could facilitate uterine hypertrophy and the proliferation of endometrial gland tissue. Figure 1 Uterine size and histological performance. (A) Body weight change at the

Open access

Teresa Lam, Mark McLean, Amy Hayden, Anne Poljak, Birinder Cheema, Howard Gurney, Glenn Stone, Neha Bahl, Navneeta Reddy, Haleh Shahidipour and Vita Birzniece

.104 7 Hughes VA Frontera WR Roubenoff R Evans WJ Singh MA . Longitudinal changes in body composition in older men and women: role of body weight change and physical activity . American Journal of Clinical Nutrition 2002 76 473 – 481 . ( https

Open access

Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz and Marek Strączkowski

weight changes were assessed every 2 weeks. The compliance was also assessed every 2 weeks by qualified dieticians – each participant reported non-adherence to the prescribed diet in a diary. Furthermore, at each visit, participants presented the detailed

Open access

Mojca Jensterle, Nika Aleksandra Kravos, Simona Ferjan, Katja Goricar, Vita Dolzan and Andrej Janez

 = 0.190; P  = 0.045). Twenty-five patients gained weight after 1 year, 60% of those who had 11 or 12 menstrual bleedings at baseline. There was no correlation between body weight change and fasting plasma glucose level or hormonal status (level of LH

Open access

Anna C Simcocks, Kayte A Jenkin, Lannie O’Keefe, Chrishan S Samuel, Michael L Mathai, Andrew J McAinch and Deanne H Hryciw

baseline of DIO) was reduced from weeks 2 to 6 of the treatment period, while the body weight (% change from baseline of DIO) of the DIO + O-1918-treated rats was not significantly altered ( Fig. 1B ). In terms of body composition, the body fat percentage