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glucose absorption and aggravates the progression of hyperglycemia-induced diabetic complications ( Fig. 2 ). The functional duality of SGK1 seems organ dependent and the spatial counterregulation helps to maintain the blood glucose homeostasis. However
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MPHD and adds to available evidence suggesting the importance of GH replacement in these patients ( 22 , 23 , 24 ). The effect of GH replacement therapy on several CV risk markers, including blood glucose homeostasis, BMI, waist circumference and
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blood glucose homeostasis and insulin resistance ( 30 ). Indeed, the fasting blood glucose decreased, hyperinsulinemia improved, and the area under the curve in oral glucose tolerance test and insulin tolerance test decreased significantly. The
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
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Department of Medicine, Karlstad Hospital, Karlstad, Sweden
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(GH) replacement on blood glucose homeostasis in adult nondiabetic patients with GH deficiency: real-life data from the NordiNet® International Outcome Study . Clinical Endocrinology 2016 86 192 – 198 . ( https://doi.org/10.1111/cen.13256
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Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
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Cardiovascular Research Laboratory, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
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, oxygen ( 12 ) and many inflammatory stimuli, such as those induced by cytokines ( 11 ). In relation to glucose metabolism and insulin signalling, miR-155 was shown to be a positive regulator of insulin sensitivity and required for normal blood glucose
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Fussenegger M . A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice . Science 2011 332 1565 – 1568 . ( https://doi.org/10.1126/science.1203535 ) 143 Shao J Xue S Yu G Yu Y Yang X Bai Y Zhu S Yang