Yun Cai
Yun Cai
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Jieni Yan
Jieni Yan
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Yong Gu
Yong Gu
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Heng Chen
Heng Chen
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Yang Chen
Yang Chen
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Xinyu Xu
Xinyu Xu
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Mei Zhang
Mei Zhang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Liping Yu
Liping Yu
Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA
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Xuqin Zheng
Xuqin Zheng
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Tao Yang
Tao Yang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Introduction Autoimmune thyroid disease (AITD) is a common organ-specific autoimmune disorder which includes two main clinical diseases: Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Both GD and HT share the immunologic manifestation
Mírian Romitti
Mírian Romitti
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Vitor C Fabris
Vitor C Fabris
Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, and Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Patricia K Ziegelmann
Patricia K Ziegelmann
Postgraduate Program in Epidemiology and Department of Statistics, Institute of Mathematics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Ana Luiza Maia
Ana Luiza Maia
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Poli Mara Spritzer
Poli Mara Spritzer
Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, and Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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association between PCOS and autoimmune diseases ( 21 , 22 ) and especially autoimmune thyroid diseases (AITD), the most common form of autoimmune disorder, with an estimated prevalence of 5% ( 23 , 24 , 25 ). AITD results from a dysregulation of the
Weiwei He
Weiwei He
Department of Endocrinology, Affiliated Hospital of Yanan Medical University, Shaanxi, China
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Bin Wang
Bin Wang
Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
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Kaida Mu
Kaida Mu
Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
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Jing Zhang
Jing Zhang
Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
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Yanping Yang
Yanping Yang
Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
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Wei Yao
Wei Yao
Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
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Sheli Li
Sheli Li
Department of Endocrinology, Affiliated Hospital of Yanan Medical University, Shaanxi, China
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Jin-an Zhang
Jin-an Zhang
Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
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Introduction In autoimmune thyroid diseases (AITDs), one of the autoimmune diseases, cytokine-mediated immunity play a key role during the pathogenesis and development ( 1 ). AITDs are common endocrine autoimmune diseases with prevalence of
Mengxue Yang
Mengxue Yang
Department of Endocrinology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, China
Department of Endocrinology, Zunyi Medical University, Zunyi, China
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Department of Endocrinology, Zunyi Medical University, Zunyi, China
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Bowen Sun
Bowen Sun
Department of Endocrinology, Zunyi Medical University, Zunyi, China
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Jianhui Li
Jianhui Li
Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China
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Bo Yang
Bo Yang
Department of Endocrinology, Zunyi Medical University, Zunyi, China
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Jie Xu
Jie Xu
School of Public Health, Zunyi Medical University, Zunyi, China
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Xue Zhou
Xue Zhou
Department of Endocrinology, Zunyi Medical University, Zunyi, China
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Jie Yu
Jie Yu
School of Public Health, Zunyi Medical University, Zunyi, China
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Xuan Zhang
Xuan Zhang
Department of Endocrinology, Zunyi Medical University, Zunyi, China
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Qun Zhang
Qun Zhang
Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China
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Shan Zhou
Shan Zhou
Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China
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Xiaohua Sun
Xiaohua Sun
Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China
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Introduction Graves’ disease (GD) is an organ-specific autoimmune thyroid disease (AITD) ( 1 , 2 ) and the most common cause of hyperthyroidism in iodine-sufficient geographical areas ( 3 ). According to the literature, the prevalence of
T Grimmichova
T Grimmichova
Institute of Endocrinology, Narodni, Prague, Czech Republic
2nd Department of Internal Medicine, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, Srobarova, Prague, Czech Republic
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2nd Department of Internal Medicine, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, Srobarova, Prague, Czech Republic
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M Haluzik
M Haluzik
Institute of Endocrinology, Narodni, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska, Prague, Czech Republic
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Diabetes Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska, Prague, Czech Republic
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K Vondra
K Vondra
Institute of Endocrinology, Narodni, Prague, Czech Republic
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P Matucha
P Matucha
Institute of Endocrinology, Narodni, Prague, Czech Republic
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M Hill
M Hill
Institute of Endocrinology, Narodni, Prague, Czech Republic
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than men, in autopsy studies the female/male ratio is the same ( 8 ). (4) Autoimmune thyroid disease (AITD). Studies have produced contradictory results and AITD can even be a protective factor in TC progression ( 9 , 10 ). (5) Both iodine deficiency
Jia Liu
Jia Liu
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Min Liu
Min Liu
Department of Radiology, China-Japan Friendship Hospital, Beijing, China
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Zhe Chen
Zhe Chen
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yumei Jia
Yumei Jia
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Guang Wang
Guang Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Introduction Autoimmune thyroiditis (AIT) is the most common autoimmune thyroid disease ( 1 , 2 ). Because of varying degree of thyroid destruction, AIT patients manifest with different thyroid function including euthyroidism, subclinical or
Yun Hu
Yun Hu
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
Department of Immunology, Nanjing Medical University, Jiangsu, China
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Department of Immunology, Nanjing Medical University, Jiangsu, China
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Na Li
Na Li
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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Peng Jiang
Peng Jiang
Department of Thyroid and Breast Surgery, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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Liang Cheng
Liang Cheng
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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Bo Ding
Bo Ding
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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Xiao-Mei Liu
Xiao-Mei Liu
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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Ke He
Ke He
Department of Endocrinology, Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangsu, China
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Yun-Qing Zhu
Yun-Qing Zhu
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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Bing-li Liu
Bing-li Liu
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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Xin Cao
Xin Cao
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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Hong Zhou
Hong Zhou
Department of Immunology, Nanjing Medical University, Jiangsu, China
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Xiao-Ming Mao
Xiao-Ming Mao
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
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relationship between thyroid nodule and thyroid cancer ( 3 , 4 ). Thyroid nodules are usually accompanied by an increase in thyroglobulin (Tg) ( 5 , 6 ) and autoimmune thyroid diseases (AITDs), especially Hashimoto’s thyroiditis (HT) ( 7 , 8 ). Interestingly
Clara Lundetoft Clausen
Clara Lundetoft Clausen
Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
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Åse Krogh Rasmussen
Åse Krogh Rasmussen
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Copenhagen, Denmark
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Trine Holm Johannsen
Trine Holm Johannsen
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
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Linda Maria Hilsted
Linda Maria Hilsted
Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark
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Niels Erik Skakkebæk
Niels Erik Skakkebæk
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
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Pal Bela Szecsi
Pal Bela Szecsi
Department of Clinical Biochemistry, Holbæk Hospital, Holbæk, Denmark
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Lise Pedersen
Lise Pedersen
Department of Clinical Biochemistry, Holbæk Hospital, Holbæk, Denmark
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Thomas Benfield
Thomas Benfield
Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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patients with TSH concentrations <0.4 mIU/L. Many different cytokines have been linked to autoimmune thyroid diseases, such as IL-8 and IP-10, which in prior studies have been reported in Graves’ disease and Graves’ orbitopathy ( 13 , 14 , 21 , 22 , 23
Sriharsha Gunna
Sriharsha Gunna
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Mahaveer Singh
Mahaveer Singh
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Rakesh Pandey
Rakesh Pandey
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Rungmei S K Marak
Rungmei S K Marak
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Amita Aggarwal
Amita Aggarwal
Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Bibhuti Mohanta
Bibhuti Mohanta
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Liping Yu
Liping Yu
Barbara Davis Centre for Diabetes, School of Medicine University of Colorado, Aurora, Colorado, USA
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Eesh Bhatia
Eesh Bhatia
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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(9%) 0 0.52 Farming profession 19 (21%) 18 (45%) 0 0 1 (7%) <0.001 Autoimmune thyroid disease h,i 14/75 (19%) 2 (5%) b 0 d 12 (55%) 0 <0.001 Thyroid peroxidase antibody 23/69 (33%) 6/32 (19%) b 3
Xuan Luo
Xuan Luo
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Tingting Zheng
Tingting Zheng
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Chaoming Mao
Chaoming Mao
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Xin Dong
Xin Dong
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Xiao Mou
Xiao Mou
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Chengcheng Xu
Chengcheng Xu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Qingyan Lu
Qingyan Lu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Baocui Liu
Baocui Liu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Shengjun Wang
Shengjun Wang
Department of Laboratory Immunology, Jiangsu University School of Medicine, Zhenjiang, China
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Yichuan Xiao
Yichuan Xiao
Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
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maintenance of the inflammatory process, which ultimately leads to autoimmune thyroid diseases such as HT and Graves’ disease ( 18 , 19 , 20 , 21 , 22 , 23 ). In the present study, for the first time, we demonstrated the potential role of MRP14 in HT
