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Sofia S Pereira, Mariana P Monteiro, Sonir R Antonini and Duarte Pignatelli

the main reasons associated to adrenal tumor cells resistance to chemotherapy is compromised apoptosis signaling, a fact that deregulates the balance between cell death and survival, thus facilitating tumor development, invasion and resistance to

Open access

Corina Verónica Sasso, Flavia Eliana Santiano, Fiorella Campo Verde Arboccó, Leila Ester Zyla, Silvana Noemí Semino, Martin Eduardo Guerrero-Gimenez, Virginia Pistone Creydt, Constanza Matilde López Fontana and Rubén Walter Carón

proliferation, loss of differentiation and decrease in apoptosis in the colon epithelium, suggesting an important role of this receptor in the normal organization and structural maintenance of the colon ( 11 ). Moreover, colon cancer cell lines have been

Open access

Chenghao Piao, Xiaojie Wang, Shiqiao Peng, Xinyu Guo, Hui Zhao, Li He, Yan Zeng, Fan Zhang, Kewen Zhu and Yiwei Wang

recombinant mouse IL-34 (rmIL-34) on apoptosis and pancreatic β cell function. Materials and methods Study groups A cross-section study was performed at the Second Affiliated Hospital of Shenyang Medical University. A total of 120 women were

Open access

Chanyang Kim and Seungjoon Park

dopaminergic neurodegeneration are not still elucidated, numerous lines of evidence indicate that mitochondrial dysfunction and oxidative stress-mediated apoptosis play an important role in the pathogenesis of PD ( 3 , 4 ). Some neurotoxins, such as 1-methyl-4

Open access

Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Kłych-Ratuszny, Mohammad Reza F Aghdam, Michał Woz´niak, Andrzej Witek, Agnieszka Wróblewska-Czech, Anna Cygal, Jerzy Wojnar and Tomasz Francuz

compared to patients on metformin or patients without diabetes. To date, metformin has proven to give beneficial effects in patients with cancer, leading to longer survival rates, better prognosis and in vitro inducing apoptosis of some tumor cell lines

Open access

Carina Hasenoehrl, Gert Schwach, Nassim Ghaffari-Tabrizi-Wizsy, Robert Fuchs, Nadine Kretschmer, Rudolf Bauer and Roswitha Pfragner

-cancer effects of shikonin have been published. As reviewed by Andújar and coworkers ( 13 ), shikonin exerts its anti-tumor effects in a great variety of cancer cell lines through inhibition of cell proliferation and induction of apoptosis. Furthermore, shikonin

Open access

Kazunori Morohoshi, Ryo Mochinaga, Tsukasa Watanabe, Ryojun Nakajima and Toshio Harigaya

properties ( 4 ). Vasoinhibins (Vi) are generated by proteolytic cleavage within the long-loop structure connecting the third helix and the fourth helix of PRL ( 5 ). Vi can act on endothelial cells to induce apoptosis and inhibit proliferation and migration

Open access

Wei Li, Qing Huang, Danyang Sun, Guizhi Zhang and Jian Tan

conducted in thyroid cancer cell lines. Lentivirus-mediated small interfering RNA (siRNA) targeting of RDM1 was used to downregulate gene expression. Then, experiments were performed to examine the effect of RDM1 silencing on the cell cycle, apoptosis

Open access

Joanna Klubo-Gwiezdzinska, John Costello Jr, Kirk Jensen, Aneeta Patel, Rok Tkavc, Douglas Van Nostrand, Kenneth D Burman, Leonard Wartofsky and Vasyl Vasko

radioprotective activity in normal cells, amifostine may enhance radiation-inducible apoptosis in cancer cells harboring oncogene mutations. It has to be noted that, despite the clinical use of amifostine in treatment of thyroid cancer patients, there is no

Open access

M L Gild, M Bullock, C K Pon, B G Robinson and R J Clifton-Bligh

it is this mechanism that is exploited when targeting its inhibition (5) . HSP90 client proteins include many kinases involved in apoptosis and signaling. These include AKT (and its phosphorylated form), p53, Raf-1, Bcr-abl, and BRAF; many of these