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M Axelstad Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark

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U Hass Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark

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M Scholze Brunel University, Uxbridge, UK

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S Christiansen Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark

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A Kortenkamp Brunel University, Uxbridge, UK

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J Boberg Technical University of Denmark, National Food Institute, Kongens Lyngby, Denmark

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investigating how male reproduction may be influenced by developmental exposure of rats to the painkiller paracetamol or to mixtures of human relevant environmental EDCs. In addition to a therapeutically relevant dose of paracetamol, a mixture of 8 anti-androgenic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0307
Volume/Issue:
Volume 7: Issue 1
Open access
Lachlan Angus Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia

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Shalem Leemaqz Robinson Research Institute, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia

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Olivia Ooi Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia

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Pauline Cundill Equinox Gender Diverse Clinic, Thorne Harbour Health, Fitzroy, Victoria, Australia

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Nicholas Silberstein Equinox Gender Diverse Clinic, Thorne Harbour Health, Fitzroy, Victoria, Australia

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Peter Locke Equinox Gender Diverse Clinic, Thorne Harbour Health, Fitzroy, Victoria, Australia

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Jeffrey D Zajac Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia

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Ada S Cheung Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia

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differing mechanisms of action. Spironolactone is a mineralocorticoid receptor antagonist and is anti-androgenic in four ways. First, it is a peripheral androgen receptor partial antagonist (IC50 = 77 nmol/L) ( 10 ). The IC50, which is the concentration of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0272
Volume/Issue:
Volume 8: Issue 7
Open access
Yen Kheng Tan Duke-NUS Medical School, SingHealth, Singapore, Singapore

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Yu Heng Kwan Department of Internal Medicine, Singapore General Hospital, Singapore, Singapore

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David Choon Liang Teo Department of Psychological Medicine, Changi General Hospital, Singapore, Singapore

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Marieke Velema Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Jaap Deinum Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Pei Ting Tan Department of Clinical Trials Research Unit, Changi General Hospital, Singapore, Singapore

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Meifen Zhang Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Joan Joo Ching Khoo Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Wann Jia Loh Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Linsey Gani Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Thomas F J King Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Eberta Jun Hui Tan Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Shui Boon Soh Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Vanessa Shu Chuan Au Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Tunn Lin Tay Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Lily Mae Quevedo Dacay Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Keng Sin Ng Department of Diagnostic Radiology, Changi General Hospital, Singapore, Singapore

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Kang Min Wong Department of Diagnostic Radiology, Changi General Hospital, Singapore, Singapore

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Andrew Siang Yih Wong Department of Surgery, Changi General Hospital, Singapore, Singapore

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Foo Cheong Ng Department of Urology, Changi General Hospital, Singapore, Singapore

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Tar Choon Aw Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore

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Yvonne Hui Bin Chan Duke-NUS Medical School, SingHealth, Singapore, Singapore

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Khim Leng Tong Department of Cardiology, Changi General Hospital, Singapore, Singapore

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Sheldon Shao Guang Lee Department of Cardiology, Changi General Hospital, Singapore, Singapore

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Siang Chew Chai Department of Cardiology, Changi General Hospital, Singapore, Singapore

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Troy Hai Kiat Puar Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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anti-androgenic side effects of MR antagonists. Patient-perceived health outcomes have an increasingly important role in healthcare. One of the most widely used questionnaires is the RAND-36, a generic HRQoL questionnaire which captures multiple

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0125
Volume/Issue:
Volume 10: Issue 8
Open access
André Marques-Pinto Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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Davide Carvalho Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Serviço de Endocrinologia, Departamento de Endocrinologia, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

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oestrogenic/anti-androgenic activity that act by interfering with the oestrogen receptors (ER) or the androgen receptor (AR) (see Table 1 ). Table 1 Reported agonist and antagonist binding of several ED to ER and AR. ED ER agonism ER antagonism AR agonism AR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-13-0036
Volume/Issue:
Volume 2: Issue 3
Open access
Rachel Forfar Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK

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Mashal Hussain Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK

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Puneet Khurana Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK

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Jennifer Cook Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK

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Steve Lewis Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK

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Dillon Popat Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK

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David Jackson Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK

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Ed McIver Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK

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Jeff Jerman Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK

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Debra Taylor Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK

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Adrian JL Clark Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK

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Li F Chan Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK

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and Cellular Endocrinology 2014 394 99 – 104 . ( https://doi.org/10.1016/j.mce.2014.07.003 ) 11 Parween S Rihs S Fluck CE . Metformin inhibits the activation of melanocortin receptors 2 and 3 in vitro: a possible mechanism for its anti-androgenic

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-22-0338
Volume/Issue:
Volume 11: Issue 12
Open access
Lina S Silva-Bermudez School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Freddy J K Toloza School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Maria C Perez-Matos School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Russell J de Souza Department of Health Research Methods, Evidence, and Impact, McMaster University, Ontario, Canada

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Laura Banfield Department of Health Research Methods, Evidence, and Impact, McMaster University, Ontario, Canada

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Andrea Vargas-Villanueva School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Carlos O Mendivil School of Medicine, Universidad de los Andes, and Fundación Santa Fe de Bogotá, Section of Endocrinology, Bogotá, Colombia

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and dienogest are considered anti-androgenic ( 3 ). Given that available studies have used combined OC with distinct combinations and doses of estrogen and progestin, using a wide variety of comparators, the overall impact of each OC on metabolic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0423
Volume/Issue:
Volume 9: Issue 10
Open access
Elizabeth Micks Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA

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Greta B Raglan Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA

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Jay Schulkin Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA
Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA

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cyproterone acetate, have anti-androgenic and anti-mineralocorticoid activity, possibly leading to desirable non-contraceptive benefits in certain patients (65) . Most data regarding the differences between different progestins are from in vitro biochemical

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-15-0093
Volume/Issue:
Volume 4: Issue 4
Open access
D A Dart Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, Wales, UK
Imperial College London, London, UK

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K Ashelford Division of Cancer and Genetics, Wales Gene Park, School of Medicine, Cardiff University, Cardiff, Wales, UK

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W G Jiang Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, Wales, UK

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. Novel trifluoromethylated Enobosarm analogues with potent anti-androgenic activity in vitro and tissue selectivity in vivo . Molecular Cancer Therapeutics 2018 17 1846 – 1858 . ( https://doi.org/10.1158/1535-7163.MCT-18-0037 ) 11 Koushyar S

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Research Article
DOI:
https://doi.org/10.1530/EC-19-0340
Volume/Issue:
Volume 9: Issue 1
Open access
Frederic Schrøder Arendrup Department of Neurology, Danish Headache Center, Rigshospitalet, University of Copenhagen, Denmark

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Severine Mazaud-Guittot Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France

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Bernard Jégou Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France
EHESP-School of Public Health, Rennes, France

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David Møbjerg Kristensen Department of Neurology, Danish Headache Center, Rigshospitalet, University of Copenhagen, Denmark
Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France

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exposure resulted in decreased anogenital distance index (AGDi) among the female offspring. Prenatal APAP has previously been associated with decreased male AGDi in both experimental rodent models and humans ( 8 , 14 , 37 , 38 ), attributed to anti-androgenic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0298
Volume/Issue:
Volume 7: Issue 1
Open access
Karim Gariani Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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PCOS with NAFLD, in order to notably establish whether treatment with anti-androgenic drugs may reduce the risk of NAFLD in women with PCOS. Hypothyroidism Hypothyroidism is a frequent endocrine disorder defined by thyroid hormone insufficiency

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0490
Volume/Issue:
Volume 10: Issue 2
Open access