Search Results

You are looking at 1 - 10 of 97 items for :

  • "animal models" x
Clear All
Open access

Stephen A Martin, Kenneth A Philbrick, Carmen P Wong, Dawn A Olson, Adam J Branscum, Donald B Jump, Charles K Marik, Jonathan M DenHerder, Jennifer L Sargent, Russell T Turner and Urszula T Iwaniec

Introduction Mice are among the most commonly utilized animal models for aging-related metabolic bone disease in humans. Advantages of mice over many models include their small size, relatively short lifespan, and ease of genetic manipulation

Open access

Anna-Pauliina Iivonen, Johanna Känsäkoski, Kirsi Vaaralahti and Taneli Raivio

, and over 60% of human protein-coding genes are miRNA targets ( 5 ). The significance of miRNAs in the hypothalamus–pituitary–gonadal system regulation has been shown in several animal models. Garaffo et al. showed that miR-200 (named miR-8 in miRBase

Open access

Rajae Talbi and Victor M Navarro

the different animal models is mediated by kisspeptin vs kisspeptin co-transmitters, for example, glutamate or NKB. In this context, it is worth noting that the degree of obesity observed in the Kiss1 ARC -silenced female mice ( 57 ) is significantly

Open access

Karim Gariani, Geneviève Drifte, Irène Dunn-Siegrist, Jérôme Pugin and François R Jornayvaz

, 39) , but injection of FGF21 in animal models of insulin resistance has been shown to improve this condition (9, 10, 11, 13, 14) . Therefore, FGF21 can be considered as a pharmacological candidate useful in these conditions. Interestingly, FGF21 has

Open access

Guillem Cuatrecasas, Hatice Kumru, M Josep Coves and Joan Vidal

spinal ependymal precursors) ( 12 ). GH was shown to stimulate proliferation, differentiation, migration and survival of astrocytes and oligodendrocytes in animal models. This could be in part because of a GH-mediated neuronal anti-apoptotic effect (Akt

Open access

M Jensterle, A Podbregar, K Goricar, N Gregoric and A Janez

2 diabetes and different forms of hypogonadism ( 9 ). Furthermore, some animal models have demonstrated that GLP1 might even have a direct impact on HPT that is beyond WR ( 10 , 11 , 12 , 13 , 14 ). These observations provided an additional

Open access

Ningning Gong, Cuixia Gao, Xuedi Chen, Yu Wang and Limin Tian

The authors and journal apologise for an error in the above paper, which appeared in volume 7 part 2, pages 295–304 . The error relates to the text in the ‘Animal model’ section of the ‘Materials and methods’ section given on page 296: The

Open access

Susanna Cirera, Sophia G Moesgaard, Nora E Zois, Nathja Ravn, Jens P Goetze, Signe E Cremer, Tom Teerlink, Páll S Leifsson, Jesper L Honge, J Michael Hasenkam and Lisbeth H Olsen

cellular changes in the MV and myocardium leading to the disease and the extent to which hemodynamic features of MR affect cellular factors. Animal models of naturally occurring and experimentally induced MR are described. MMVD is the most common cause of

Open access

Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Giustino Orlando, Michele Vacca, Roberto Salvatori and Luigi Brunetti

lack the decline in cognitive ability in the Morris water maze test that is observed in WT mice ( 9 , 10 ). GHRHKO mice represent an animal model of isolated GH deficiency with otherwise normal pituitary function ( 11 ). We have recently demonstrated

Open access

Corina Verónica Sasso, Flavia Eliana Santiano, Fiorella Campo Verde Arboccó, Leila Ester Zyla, Silvana Noemí Semino, Martin Eduardo Guerrero-Gimenez, Virginia Pistone Creydt, Constanza Matilde López Fontana and Rubén Walter Carón

in animal models ( 15 ). However, other studies report the implication of P4. For example, the expression of PR increases in the order of normal colon-adenoma-adenocarcinoma, supporting its role on this disease ( 16 ). Furthermore, some studies