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Dario de Biase, Federica Torricelli, Moira Ragazzi, Benedetta Donati, Elisabetta Kuhn, Michela Visani, Giorgia Acquaviva, Annalisa Pession, Giovanni Tallini, Simonetta Piana and Alessia Ciarrocchi

elongation and unleashed cell proliferation capacity. Recently, increased frequency of mutations within the MED12 gene was reported in a large cohort of fatal non-anaplastic thyroid cancers ( 15 ). This protein is a component of the mediator complex

Open access

Ashley N Reeb, Andrea Ziegler and Reigh-Yi Lin

represent a gold standard for cancer research due to their superior xenografting capability ( 17 , 18 ). We have previously used the orthotopic and tail vein injection models in NSG mice to study the anaplastic thyroid cancer cell (ATC) lines THJ-11T and

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Tiemo S Gerber, Arno Schad, Nils Hartmann, Erik Springer, Ulrich Zechner and Thomas J Musholt

showed a KIT mutation ( 37 ). In our study, we detected four KIT variants. This discrepancy may indicate a slowing effect on cancer growth that is lost during tumour dedifferentiation to anaplastic thyroid cancer, which may be lost in favour of a more

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Nassim Ghaffari-Tabrizi-Wizsy, Christina Angelika Passegger, Laura Nebel, Fabian Krismer, Gudrun Herzer-Schneidhofer, Gert Schwach and Roswitha Pfragner

Searle K Lowerison M Ruicci K Yoo J Fung K MacNeil D Lacefield C , et al . Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models . PLoS One 2018 13 e0207152 . ( https://doi.org/10.1371/journal.pone.0207152 ) 30419054 10

Open access

Simonetta Piana, Eleonora Zanetti, Alessandra Bisagni, Alessia Ciarrocchi, Davide Giordano, Federica Torricelli, Teresa Rossi and Moira Ragazzi

induces cellular differentiation in anaplastic thyroid cancer . Annals of Surgical Oncology 2014 21 S497 – S504 . ( https://doi.org/10.1245/s10434-013-3459-7 ) 10.1245/s10434-013-3459-7) 30 Yuan L Ma L Xue H Song S . Relationship between

Open access

Aleksandra Kukulska, Jolanta Krajewska, Zofia Kolosza, Ewa Paliczka-Cieslik, Aleksandra Kropinska, Agnieszka Pawlaczek, Zbigniew Puch, Kornelia Ficek, Teresa Lisik, Dorota Sygula, Zbigniew Wygoda, Jozef Roskosz, Jerzy Wydmanski and Barbara Jarzab

on the course of non-anaplastic thyroid cancer (including 12 MTC patients) and it did not show any beneficial effect on the local MTC control and survival ( 19 ). While, in 1996 Brierley et al . achieved a better local control only in irradiated

Open access

C Sui, Q He, R Du, D Zhang, F Li, G Dionigi, N Liang and H Sun

, medullary thyroid cancer; ATC, anaplastic thyroid cancer; DTC, differentiated thyroid cancer. Clinicopathological characteristics of patients All DTCs were confirmed to be N1 by the postoperative pathologic examination of resected tumor and

Open access

Barbora Pekova, Sarka Dvorakova, Vlasta Sykorova, Gabriela Vacinova, Eliska Vaclavikova, Jitka Moravcova, Rami Katra, Petr Vlcek, Pavla Sykorova, Daniela Kodetova, Josef Vcelak and Bela Bendlova

% or more of pediatric thyroid cancer ( 4 ). Medullary (MTC) and follicular thyroid cancer (FTC) are relatively rare. MTC is mostly familial than sporadic in children and adolescents. Poorly differentiated cancer and anaplastic thyroid cancer (ATC) have

Open access

Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi and Lewis Hassell

Shah RH Dogan S Ricarte-Filho JC Krishnamoorthy GP Xu B , et al . Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers . Journal of Clinical Investigation 2016 126 1052 – 1066 . ( doi:10

Open access

Joanna Klubo-Gwiezdzinska, John Costello Jr, Kirk Jensen, Aneeta Patel, Rok Tkavc, Douglas Van Nostrand, Kenneth D Burman, Leonard Wartofsky and Vasyl Vasko

University of the Health Sciences. Human thyroid cancer cell lines derived from follicular thyroid cancer (FTC133), papillary thyroid cancer (TPC1 and BCPAP) and anaplastic thyroid cancer (C643) cells, as well as NIH3T3 mouse embryonic fibroblast cells were