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Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh and Tetsuo Kondo

aggressive and associated with a poor prognosis ( 2 ). Criteria for TCVPTC was first proposed in 1976 by Hawk and Hazard ( 3 ). In the previous WHO 2004 classification, however, the morphological criterion for the diagnosis of TCVPTC was vague: ‘The TCV is

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G Giuffrida, F Ferraù, R Laudicella, O R Cotta, E Messina, F Granata, F F Angileri, A Vento, A Alibrandi, S Baldari and S Cannavò

‘invasive’ or ‘aggressive’ ( 1 ). Moreover, the term ‘giant’ adenoma is usually applied to those tumors exceeding 40 mm in maximum diameter ( 2 ). In PT patients, multimodal treatment, including neurosurgery, drugs and radiotherapy, is generally effective

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Ashley K Clift, Oskar Kornasiewicz, Panagiotis Drymousis, Omar Faiz, Harpreet S Wasan, James M Kinross, Thomas Cecil and Andrea Frilling

’ phenotype with regards to aggressiveness between appendiceal neuroendocrine neoplasms (ANEN) and adenocarcinoma has been described ( 3 , 4 ), their incidence of 0.05/100,000/year ( 5 ) renders clinical experience limited. A median age at diagnosis of 58

Open access

Dario de Biase, Federica Torricelli, Moira Ragazzi, Benedetta Donati, Elisabetta Kuhn, Michela Visani, Giorgia Acquaviva, Annalisa Pession, Giovanni Tallini, Simonetta Piana and Alessia Ciarrocchi

classified into three categories: well-differentiated, poorly differentiated and anaplastic. Aggressiveness and lethality of the tumors decrease with grade of cell differentiation ( 2 ). Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive form

Open access

Renea A Taylor, Jennifer Lo, Natasha Ascui and Matthew J Watt

–2011 data) (1) . This is in contrast to other more aggressive cancers that have significantly lower 5-year survival rates (e.g., 17.4 and 64.9% in lung and colorectal cancer respectively) (1) . Consequently, there are many men who live with prostate cancer

Open access

Ashley N Reeb, Andrea Ziegler and Reigh-Yi Lin

thyroid of 8-week-old female NSG mice ( n = 2 per cell line). Tumor initiation and growth were monitored weekly via bioluminescent live imaging using IVIS. Notably, WRO-derived tumors were more aggressive and invasive and grew two to four times faster

Open access

Catarina Tavares, Maria João Coelho, Catarina Eloy, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batista, Luciana Bueno Ferreira, Elisabete Rios, Samia Selmi-Ruby, Bruno Cavadas, Luísa Pereira, Manuel Sobrinho Simões and Paula Soares

of PTC; U/I, unavailable information. Discussion In this work, we tried to clarify the impact of NIS expression (mRNA and protein) on thyroid tumors’ aggressiveness and therapy success and, as a result of the above, the putative

Open access

Adrian F Daly, David A Cano, Eva Venegas-Moreno, Patrick Petrossians, Elena Dios, Emilie Castermans, Alvaro Flores-Martínez, Vincent Bours, Albert Beckers and Alfonso Soto-Moreno

neurosurgery, medical therapy and radiotherapy can be needed to treat pituitary adenomas ( 4 , 5 , 6 , 7 ). There is an increased likelihood of aggressive pituitary adenoma characteristics (early age at diagnosis, large tumor size, increased invasiveness

Open access

Simonetta Piana, Eleonora Zanetti, Alessandra Bisagni, Alessia Ciarrocchi, Davide Giordano, Federica Torricelli, Teresa Rossi and Moira Ragazzi

( 20 , 21 ). In line with this reports, we recently reported that NOTCH1 cooperates with the transcription factor DEC1 in controlling aggressiveness of PTCs ( 22 ). Despite the involvement of NOTCH1 in thyroid carcinogenesis, still many issues remain

Open access

M S Elston, V B Crawford, M Swarbrick, M S Dray, M Head and J V Conaglen

secondary to prostate neuroendocrine carcinoma ( 15 ). While somatostatin receptor scintigraphy can be helpful to identify neuroendocrine tumours such as bronchial carcinoids causing CS, given the likely aggressive underlying tumour in this setting, FDG