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Sebastião Freitas de Medeiros, Márcia Marly Winck Yamamoto, Matheus Antônio Souto de Medeiros, Bruna Barcelo Barbosa, José Maria Soares Junior and Edmund Chada Baracat

.001). Despite ovarian volume being larger in PCOS patients than in controls in each five-year range age group, from ≤19 years to 39 years ( P  < 0.001 for all strata comparisons), the tendency analyses showed that the ovarian volume presented a non

Open access

Volha V Zhukouskaya, Anya Rothenbuhler, Annamaria Colao, Carolina Di Somma, Peter Kamenický, Séverine Trabado, Dominique Prié, Christelle Audrain, Anna Barosi, Christèle Kyheng, Anne-Sophie Lambert and Agnès Linglart

and methods The entire patients’ follow-up period was from birth till the age of 20 years and was divided into five sub-periods defining age groups from 0 to 4. Group 0 included the parameters at birth, and groups 1, 2, 3, and 4 comprised the follow

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Shilpa Lingaiah, Laure Morin-Papunen, Terhi Piltonen, Inger Sundström-Poromaa, Elisabet Stener-Victorin and Juha S Tapanainen

-related changes of RBP4 between different age groups. Pearson’s correlation coefficients were used to assess the correlation between RBP4 and different variables, and adjustment for age and BMI was carried out by way of partial correlation analyses. Values of P

Open access

Manjeetkaur Sehemby, Prachi Bansal, Vijaya Sarathi, Ashwini Kolhe, Kanchan Kothari, Swati Jadhav-Ramteke, Anurag R Lila, Tushar Bandgar and Nalini S Shah

manifestations. Hyperestrogenic manifestations are age dependent. Prepubertal girls usually present with gonadotropin-independent isosexual precocious puberty whereas women in reproductive age group or postmenopausal age present with irregular and excessive

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Adriano N Cury, Verônica T Meira, Osmar Monte, Marília Marone, Nilza M Scalissi, Cristiane Kochi, Luís E P Calliari and Carlos A Longui

tremendous controversy regarding the most appropriate treatment schedule for this age group (3) . No strategy targets the underlying autoimmunity, and the control of thyroid hyperfunction is usually achieved by the induction of hypothyroidism. In many

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Miranda Scharff, Chantal Maria Wiepjes, Maartje Klaver, Thomas Schreiner, Guy T’Sjoen and Martin den Heijer

grip strength (−1.2 kg) occurred in the last 3 months, while in transmen 49% of the increase (+3.0 kg) occurred in the first 3 months. Change in grip strength did not vary between different age groups ( Fig. 3A ), different BMI groups ( Fig. 3B ) and

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Mirjana Kocova, Vesna Janevska and Violeta Anastasovska

-classic (NC). In the 30 males analyzed for this study in the period 2001–2016, the following disease forms were noted: SW in 16 (53.3%), SV in 9 (30%) and NC in 5 (16.7%). From 2005, we have systematically followed 25 boys in the age group 4–18 years during a

Open access

Malachi J McKenna, Barbara F Murray, Myra O'Keane and Mark T Kilbane

Background

The Institute of Medicine 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D specified higher intakes for all age groups compared to the 1997 report, but also cautioned against spurious claims about an epidemic of vitamin D deficiency and against advocates of higher intake requirements. Over 40 years, we have noted marked improvement in vitamin D status but we are concerned about hypervitaminosis D.

Objective

We sought to evaluate the 25-hydroxyvitamin D (25OHD) trend over 20 years.

Design

We retrieved all results of serum 25OHD from 1993 to 2013 (n=69 012) that was trimmed to one sample per person (n=43 782). We conducted a time series analysis of the monthly averages for 25OHD using a simple sequence chart and a running median smoothing function. We modelled the data using univariate auto-regressive integrated moving average (ARIMA) and forecast 25OHD levels up to 2016.

Results

The time series sequence chart and smoother function demonstrated a steady upward trend with seasonality. The yearly average 25OHD increased from 36.1 nmol/l in 1993 to 57.3 nmol/l in 2013. The ARIMA model was a good fit for the 25OHD time series; it forecasted monthly average 25OHD up to the end of 2016 with a positive stationary R 2 of 0.377.

Conclusions

Vitamin D status improved over the past 40 years, but there remains a dual problem: there are groups at risk of vitamin D deficiency who need public health preventative measures; on the other hand, random members of the population are taking unnecessarily high vitamin D intakes for unsubstantiated claims.

Open access

Andrea Mazurat, Andrea Torroni, Jane Hendrickson-Rebizant, Harbinder Benning, Richard W Nason and K Alok Pathak

, 96.8% (95% CI, 93.1–98.5%) for patients in the age group of 45–54 years, 85.8% (95% CI, 78.7–90.7%) for patients in the age group of 55–64 years, and 74.0% (95% CI, 70.0–79.8%) for patients older than 65 years. Figure 1 shows no significant

Open access

T Grimmichova, M Haluzik, K Vondra, P Matucha and M Hill

.05. Two-way ANOVA consisting of factors and diagnostic group (NDM, PDM, and T2DM) as well as age group (45–59 vs >60 years of age) with interactions between these factors was used to evaluate the effects of status and age. Due to the non-Gaussian data