Search Results
Search for other papers by Mark R Postma in
Google Scholar
PubMed
Search for other papers by Pia Burman in
Google Scholar
PubMed
Search for other papers by André P van Beek in
Google Scholar
PubMed
Introduction:
Adult-onset growth hormone deficiency (AGHD) is usually the last deficiency to be substituted in hypopituitarism. In children with documented GH deficiency, treatment without delay is crucial for achieving optimal effects on growth and development. In adults, it is not known whether a delay in treatment initiation influences biochemical response and the favourable physiological effects resulting from GH replacement therapy (GHRT).
Methods:
A total of 1085 GH-deficient adults from KIMS (Pfizer International Metabolic Database) were included, adequately replaced with all pituitary hormones except for GH at baseline. Patients were stratified by sex and age (20–50 years and ≥50 years) and subsequently divided into two groups below and above the median duration of unsubstituted AGHD for that subgroup. The median time of unsubstituted GHD for the total cohort was 2.53 years (P5 = 0.35, P95 = 24.42).
Results:
Beneficial effects of 4 years of GHRT were observed on lipids and quality of life in all subgroups. A decrease in waist circumference was observed only in older (>50 years) patients. There was no difference in IGF-I SDS and in GH dose required to normalize IGF-I in patients with a duration of unsubstituted AGHD above or below the median. No relevant differences were found between the groups for anthropometric measures, cardiovascular risk factors and quality of life scores.
Conclusion:
In contrast to GHD in children and adolescents, no difference could be established in treatment response between early or late initiation of GHRT in AGHD in terms of required GH dose, IGF-I, metabolic health and quality of life.
Search for other papers by Johan Verhelst in
Google Scholar
PubMed
Search for other papers by Anders F Mattsson in
Google Scholar
PubMed
Search for other papers by Cecilia Camacho-Hübner in
Google Scholar
PubMed
Search for other papers by Anton Luger in
Google Scholar
PubMed
Search for other papers by Roger Abs in
Google Scholar
PubMed
Introduction It is now well-recognized that patients with adult-onset growth hormone deficiency (AO-GHD), apart from experiencing a poor quality of life (QoL), present with an increased risk of developing a metabolic syndrome (MetS) ( 1 , 2
Search for other papers by Rachel D C A Diniz in
Google Scholar
PubMed
Search for other papers by Renata M Souza in
Google Scholar
PubMed
Search for other papers by Roberto Salvatori in
Google Scholar
PubMed
Search for other papers by Alex Franca in
Google Scholar
PubMed
Search for other papers by Elenilde Gomes-Santos in
Google Scholar
PubMed
Search for other papers by Thiago O Ferrão in
Google Scholar
PubMed
Search for other papers by Carla R P Oliveira in
Google Scholar
PubMed
Search for other papers by João A M Santana in
Google Scholar
PubMed
Search for other papers by Francisco A Pereira in
Google Scholar
PubMed
Search for other papers by Rita A A Barbosa in
Google Scholar
PubMed
Search for other papers by Anita H O Souza in
Google Scholar
PubMed
Search for other papers by Rossana M C Pereira in
Google Scholar
PubMed
Search for other papers by Alécia A Oliveira-Santos in
Google Scholar
PubMed
Search for other papers by Allysson M P Silva in
Google Scholar
PubMed
Search for other papers by Francisco J Santana-Júnior in
Google Scholar
PubMed
Search for other papers by Eugênia H O Valença in
Google Scholar
PubMed
Search for other papers by Viviane C Campos in
Google Scholar
PubMed
Search for other papers by Manuel H Aguiar-Oliveira in
Google Scholar
PubMed
. Non-alcoholic steatohepatitis and hepatic steatosis in patients with adult onset growth hormone deficiency . Gut 2003 52 914 . ( doi:10.1136/gut.52.6.914 ). 11 Tarantino G Savastano S Colao A . Hepatic steatosis, low-grade chronic
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
Search for other papers by Charlotte Höybye in
Google Scholar
PubMed
Search for other papers by Laia Faseh in
Google Scholar
PubMed
Department of Medicine, Karlstad Hospital, Karlstad, Sweden
Search for other papers by Christos Himonakos in
Google Scholar
PubMed
Search for other papers by Tomasz Pielak in
Google Scholar
PubMed
Search for other papers by Jesper Eugen-Olsen in
Google Scholar
PubMed
growth hormone deficiency . Growth Hormone and IGF Research 2011 21 69 – 75 . ( https://doi.org/10.1016/j.ghir.2011.01.001 ) 10.1016/j.ghir.2011.01.001 14 Elbornsson M Götherström G Bosæus I Bengtsson BÅ Johannsson G Svensson J . Fifteen years
Search for other papers by Pinaki Dutta in
Google Scholar
PubMed
Search for other papers by Bhuvanesh Mahendran in
Google Scholar
PubMed
Search for other papers by K Shrinivas Reddy in
Google Scholar
PubMed
Search for other papers by Jasmina Ahluwalia in
Google Scholar
PubMed
Search for other papers by Kim Vaiphei in
Google Scholar
PubMed
Search for other papers by Rakesh K Kochhar in
Google Scholar
PubMed
Search for other papers by Prakamya Gupta in
Google Scholar
PubMed
Search for other papers by Anand Srinivasan in
Google Scholar
PubMed
Search for other papers by Mahesh Prakash in
Google Scholar
PubMed
Search for other papers by Kanchan Kumar Mukherjee in
Google Scholar
PubMed
Search for other papers by Viral N Shah in
Google Scholar
PubMed
Search for other papers by Girish Parthan in
Google Scholar
PubMed
Search for other papers by Anil Bhansali in
Google Scholar
PubMed
therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial . Annals of Internal Medicine 1996 125 883 – 890 . ( doi:10.7326/0003-4819-125-11-199612010-00003 ). 26
Search for other papers by Karim Gariani in
Google Scholar
PubMed
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Search for other papers by François R Jornayvaz in
Google Scholar
PubMed
steatosis in patients with adult onset growth hormone deficiency . Gut 2003 52 914. ( https://doi.org/10.1136/gut.52.6.914 ). 118 Fusco A Miele L D'Uonnolo A Forgione A Riccardi L Cefalo C Barini A Bianchi A Giampietro A Cimino V
