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Sofia S Pereira, Tiago Morais, Madalena M Costa, Mariana P Monteiro and Duarte Pignatelli

rate of between 16 and 38% (1, 3, 4, 5) . The correct diagnosis of adrenocortical tumors (ACTs) is, therefore, understandably of growing importance. ACTs can be divided into functioning and nonfunctioning tumors based on whether they secrete steroids

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Monica F Stecchini, Zilda Braid, Candy B More, Davi C Aragon, Margaret Castro, Ayrton C Moreira and Sonir R Antonini

conditions associated with androgen excess, usually after initiation of treatment of the underlying disease ( 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ). In this context, androgen-secreting adrenocortical tumors (ACTs), which

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Sofia S Pereira, Mariana P Monteiro, Sonir R Antonini and Duarte Pignatelli

Adrenocortical tumors Adrenal cortex tumors (ACT) are common tumors with a reported prevalence above 4% in most populations ( 1 ). However, the majority of ACT are benign, non-functioning and incidentally discovered during imaging studies

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Milène Tetsi Nomigni, Sophie Ouzounian, Alice Benoit, Jacqueline Vadrot, Frédérique Tissier, Sylvie Renouf, Hervé Lefebvre, Sophie Christin-Maitre and Estelle Louiset

control tissues. Real-time RT-PCR Total RNAs were extracted from two samples of the adrenocortical tumor and seven normal adrenals by using Tri-Reagent (Sigma–Aldrich, Saint-Quentin-Fallavier, France) and purified on Nucleospin RNAII (Macherey

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Maria Cristina De Martino, Richard A Feelders, Claudia Pivonello, Chiara Simeoli, Fortuna Papa, Annamaria Colao, Rosario Pivonello and Leo J Hofland

required to clarify the specific role of the mTOR pathway in regulating steroid production. Expression of the main components of the mTOR pathway in adrenocortical tumors The expression of the main components of the mTOR pathway in adrenocortical

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Weixi Wang, Rulai Han, Lei Ye, Jing Xie, Bei Tao, Fukang Sun, Ran Zhuo, Xi Chen, Xiaxing Deng, Cong Ye, Hongyan Zhao and Shu Wang

the highly prevalent R337H mutation of tumor suppressor p53 in Brazilian patients with adrenocortical tumors . Arquivos Brasileiros de Endocrinologia and Metabologia 2004 48 647 – 650 . ( ) 10

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Gamze Akkuş, Isa Burak Güney, Fesih Ok, Mehtap Evran, Volkan Izol, Şeyda Erdoğan, Yıldırım Bayazıt, Murat Sert and Tamer Tetiker

LM . Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors . American Journal of Surgical Pathology 1984 8 . ( ) 9 Thompson LD . Pheochromocytoma of the

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Deborah Cosentini, Salvatore Grisanti, Alberto Dalla Volta, Marta Laganà, Chiara Fiorentini, Paola Perotti, Sandra Sigala and Alfredo Berruti

melanoma ( 12 ), is widely expressed in adrenocortical tumors, being one of the markers used to identify lesions with adrenocortical origin ( 13 ). JAVELIN study is a phase 1, open-label, dose-escalation trial of avelumab, antibody targeting PD-L1, with

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I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder and K Svechnikov

. Transcription factors GATA-6, SF-1, and cell proliferation in human adrenocortical tumors . Molecular and Cellular Endocrinology 2005 233 47 – 56 . ( doi:10.1016/j.mce.2005.01.012 ) 42 Huang N Dardis A Miller WL. Regulation of cytochrome b5

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Erika Peverelli, Federica Ermetici, Sabrina Corbetta, Ettore Gozzini, Laura Avagliano, Marco A Zappa, Gaetano Bulfamante, Paolo Beck-Peccoz, Anna Spada and Giovanna Mantovani

Vicentini L Arnaldi G Bosari S . Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation . Experimental Cell Research 314 2008a 123 – 130 . ( doi:10