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Jan Kvasnička 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Ondřej Petrák 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Tomáš Zelinka 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Judita Klímová 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Barbora Kološová 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Květoslav Novák Department of Urology, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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David Michalský 1st Department of Surgery, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Jiří Widimský Jr 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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Robert Holaj 3rd Department of Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Praha, Czech Republic

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, 6 ). Patients with PPGL may have more serious cardiovascular complications (even life-threatening ones, such as arrhythmias, myocardial infarction or heart failure), compared to patients with essential hypertension (EH) ( 7 ). Adrenalectomy also

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Caojie Liu West China Hospital, Sichuan University, Chengdu, China

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Qingguo Lv Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China

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Xinlei Chen West China Hospital, Sichuan University, Chengdu, China

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Guangcheng Ni West China Hospital, Sichuan University, Chengdu, China

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Liru Hu West China Hospital, Sichuan University, Chengdu, China

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Nanwei Tong Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China

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Yuwei Zhang Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China

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during adrenalectomy for pheochromocytomas, including rapid and severe blood pressure fluctuations that greatly increase the risk of major morbidity ( 7 ). Anesthetic induction, intraoperative tumor handling and accidental squeezing of the tumor can

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Kuang Hung Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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Bo-Ching Lee Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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Po-Ting Chen Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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Kao-Lang Liu Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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Chin-Chen Chang Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Department and Graduate Institute of Forensic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

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Vin-Cent Wu Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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Yen-Hung Lin Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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studies (computed tomography (CT) or magnetic resonance imaging (MRI)). Adrenalectomy has consequently been established as the treatment of choice for unilateral disease. Recently, there has been a growing focus on a special group with cortisol co

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Paola Parra Ramírez Endocrinology & Nutrition Department, La Paz University Hospital, Madrid, Spain

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Patricia Martín Rojas-Marcos Endocrinology & Nutrition Department, La Paz University Hospital, Madrid, Spain

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Miguel Paja Fano Endocrinology & Nutrition Department, Hospital Universitario de Basurto, Bilbao, Spain
Medicine Department, Basque Country University, Bilbao, Spain

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Marga González Boillos Endocrinology & Nutrition Department, Hospital Universitario de Castellón, Castellón, Spain

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Eider Pascual-Corrales Endocrinology & Nutrition Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain

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Ana García-Cano Biochemistry Department, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Jorge Gabriel Ruiz-Sanchez Endocrinology & Nutrition Department, Hospital Fundación Jiménez Díaz, Madrid, Spain

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Almudena Vicente Endocrinology & Nutrition Department, Complejo Universitario de Toledo, Toledo, Spain

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Emilia Gómez-Hoyos Endocrinology & Nutrition Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain

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Rui Ferreira Endocrinology & Nutrition Department, Hospital Universitario de La Princesa, Madrid, Spain

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Iñigo García Sanz General & Digestive Surgery Department, Hospital Universitario de La Princesa, Madrid, Spain

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Mònica Recasens Endocrinology & Nutrition Department, Hospital Josep Trueta, Servei d’Endocrinologia, Girona, Spain

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Begoña Pla Peris Endocrinology & Nutrition Department, Hospital Universitario de Castellón, Castellón, Spain

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Rebeca Barahona San Millan Endocrinology & Nutrition Department, Hospital Josep Trueta, Servei d’Endocrinologia, Girona, Spain

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María José Picón César Endocrinology & Nutrition Department, Complejo Hospitalario Málaga (Hospital Virgen de la Victoria), IBIMA Malaga, Malaga, Spain
CIBEROBN, Madrid, Spain

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Patricia Díaz Guardiola Endocrinology & Nutrition Department, Hospital Universitario Infanta Sofía, Madrid, Spain

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Juan Jesús García González Endocrinology & Nutrition Department, Hospital Universitario Virgen de la Macarena, Sevilla, Spain

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Carolina Perdomo Endocrinology & Nutrition Department, Clínica Universidad de Navarra, Pamplona, Spain

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Laura Manjón Endocrinology & Nutrition Department, Hospital Universitario Central de Asturias, Oviedo, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain

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Rogelio García-Centeno Endocrinology & Nutrition Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain

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Juan Carlos Percovich Endocrinology & Nutrition Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain

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Ángel Rebollo Román Endocrinology & Nutrition Department, Hospital Reina Sofía, Córdoba, Spain

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Paola Gracia Gimeno Endocrinology & Nutrition Department, Hospital Royo Villanova, Zaragoza, Spain

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Cristina Robles Lázaro Endocrinology & Nutrition Department, Hospital Universitario de Salamanca, Salamanca, Spain

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Manuel Morales Biochemistry and Molecular Genetics Department-CDB, Hospital Clinic, IDIBAPS, CIBERehd, Barcelona, Spain

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Felicia Hanzu Endocrinology & Nutrition Department, Hospital Clinic, Barcelona, Spain

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Marta Araujo-Castro Endocrinology & Nutrition Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain
University of Alcalá, Madrid, Spain

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study was to compare the characteristics of PA that are present at diagnosis and during follow-up, including the results in adrenal venous sampling (AVS) and adrenalectomy, in elderly patients (≥65 years) and younger patients than 65 years old, to

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Sofia Maria Lider Burciulescu University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania
National Institute of Endocrinology CI Parhon, Bucharest, Romania

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Monica Livia Gheorghiu University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania
National Institute of Endocrinology CI Parhon, Bucharest, Romania

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Andrei Muresan National Institute of Endocrinology CI Parhon, Bucharest, Romania

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Iuliana Gherlan University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania
National Institute of Endocrinology CI Parhon, Bucharest, Romania

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Attila Patocs Department of Laboratory Medicine and Molecular Genetics, Clinical Genetics and Endocrinology Laboratory, Semmelweis University National Institute of Oncology, Budapest, Hungary

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Corin Badiu University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania
National Institute of Endocrinology CI Parhon, Bucharest, Romania

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eventually develop bilateral tumors but are followed regularly ( 10 , 11 ). The most frequently surgery technique used by surgeon is total adrenalectomy. Many patients develop the second pheochromocytoma several years after the first unilateral tumor was

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Yen Kheng Tan Duke-NUS Medical School, SingHealth, Singapore, Singapore

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Yu Heng Kwan Department of Internal Medicine, Singapore General Hospital, Singapore, Singapore

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David Choon Liang Teo Department of Psychological Medicine, Changi General Hospital, Singapore, Singapore

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Marieke Velema Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Jaap Deinum Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Pei Ting Tan Department of Clinical Trials Research Unit, Changi General Hospital, Singapore, Singapore

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Meifen Zhang Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Joan Joo Ching Khoo Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Wann Jia Loh Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Linsey Gani Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Thomas F J King Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Eberta Jun Hui Tan Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Shui Boon Soh Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Vanessa Shu Chuan Au Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Tunn Lin Tay Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Lily Mae Quevedo Dacay Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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Keng Sin Ng Department of Diagnostic Radiology, Changi General Hospital, Singapore, Singapore

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Kang Min Wong Department of Diagnostic Radiology, Changi General Hospital, Singapore, Singapore

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Andrew Siang Yih Wong Department of Surgery, Changi General Hospital, Singapore, Singapore

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Foo Cheong Ng Department of Urology, Changi General Hospital, Singapore, Singapore

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Tar Choon Aw Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore

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Yvonne Hui Bin Chan Duke-NUS Medical School, SingHealth, Singapore, Singapore

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Khim Leng Tong Department of Cardiology, Changi General Hospital, Singapore, Singapore

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Sheldon Shao Guang Lee Department of Cardiology, Changi General Hospital, Singapore, Singapore

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Siang Chew Chai Department of Cardiology, Changi General Hospital, Singapore, Singapore

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Troy Hai Kiat Puar Department of Endocrinology, Changi General Hospital, Singapore, Singapore

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depression ( 4 , 5 ). Generally, bilateral PA is treated with mineralocorticoid receptor (MR) antagonists, while unilateral PA is managed with unilateral adrenalectomy ( 6 ). Studies have found better cardiovascular events and HRQoL outcomes following

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Marianna Viukari Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

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Helena Leijon Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland

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Tiina Vesterinen Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland

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Sanni Söderlund Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

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Päivi Hämäläinen Department of Internal Medicine, Tampere University Hospital, Tampere, Finland

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Iina Yliaska Medical Research Center Oulu, Oulu University Hospital and Research Unit of Internal Medicine, University of Oulu, Oulu, Finland

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Päivi Rautiainen Joint Municipal Authority for North Karelia Social and Health Services (Siun Sote), Joensuu, Finland

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Reeta Rintamäki Department of Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland

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Minna Soinio Department of Endocrinology, Turku University Hospital, Turku, Finland

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Ilkka Pörsti Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

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Pasi I Nevalainen Department of Internal Medicine, Tampere University Hospital, Tampere, Finland

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Niina Matikainen Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

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higher incidence of postsurgical disease and increased aldosterone production from the remaining adrenal ( 8 , 10 , 12 , 13 ). This indicates the need for follow-up even when initial adrenalectomy results imply a cure. The gold standard for

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Randi Ugleholdt Department of Endocrinology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Åse Krogh Rasmussen Department of Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Pernille A H Haderslev Department of Anaesthesiology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark

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Bjarne Kromann-Andersen Department of Urology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark

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Claus Larsen Feltoft Department of Endocrinology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark

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. Patients with a histological diagnosis of pheochromocytoma or paraganglioma but not pretreated with PBZ were excluded from the dataset. In addition, we included 34 control subjects who underwent laparoscopic adrenalectomy during 2011–2015 at the same

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Daisuke Watanabe Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Satoshi Morimoto Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Noriko Morishima Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Atsuhiro Ichihara Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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than among those with essential hypertension (EH) ( 3 ). In addition, severe arterial stiffness is associated with the absence of complete clinical success in lateralized PA after adrenalectomy (ADX) ( 4 ). Endothelial dysfunction is recognized as a

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Henghai Huang Department of Urology, Department of Urology, Wuzhou GongRen Hospital, Wuzhou, China

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Qijian Ding Department of Urology, The First Affiliated Hospital of GuangXi Medical University, Nanning China

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Xiaocao Lin Department of Urology, Department of Urology, Wuzhou GongRen Hospital, Wuzhou, China

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Delin Li Department of Urology, Department of Urology, Wuzhou GongRen Hospital, Wuzhou, China

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Jingjing Zeng Department of Pathology, The First Affliated Hospital of GuangXi Medical University, Nanning, China

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Weijin Fu Department of Urology, The First Affiliated Hospital of GuangXi Medical University, Nanning China

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CT images. Slight, early enhancement was seen in the postcontrast images in all of the patients. All of the AS patients underwent operative resection by open adrenalectomy (five patients) and laparoscopy (the remaining eight patients). Surgical

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