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Chiara Mele Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy

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Maria Teresa Samà Division of Endocrinology, University Hospital ‘Maggiore della Carità’, Novara, Italy

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Alessandro Angelo Bisoffi Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy

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Marina Caputo Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy

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Valentina Bullara Division of Endocrinology, University Hospital ‘Maggiore della Carità’, Novara, Italy

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Stefania Mai Laboratory of Metabolic Research, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy

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Gillian Elisabeth Walker Department of Health Sciences, University of Piemonte Orientale, Novara, Italy

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Flavia Prodam Department of Health Sciences, University of Piemonte Orientale, Novara, Italy

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Paolo Marzullo Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy

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Gianluca Aimaretti Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy

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Loredana Pagano Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy

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). Although the pathways linking obesity and IR to thyroid cancer remain largely unknown, a potential role for insulin, growth hormone (GH) secretagogues and adipokines has been postulated ( 10 ). Insulin not only regulates cell metabolism but also stimulates

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Ningning Gong Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
Department of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China

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Cuixia Gao Department of Ultrasonic Diagnosis, Gansu Provincial Hospital, Lanzhou, China

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Xuedi Chen Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Yu Wang Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Limin Tian Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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atherosclerosis (AS) was reported in a large population-based study ( 2 , 3 ). Multiple lines of evidence have shown that adipokines ( 4 ), endothelial dysfunction ( 5 ) and dyslipidemia ( 6 ) play a central role in the development of AS, but the relationship

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Katarzyna Wyskida Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland

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Grzegorz Franik Department of Gynecological Endocrinology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland

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Tomasz Wikarek Department of Gynecology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland

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Aleksander Owczarek Department of Statistics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland

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Alham Delroba Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland

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Jerzy Chudek Pathophysiology Unit, Department of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland

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Jerzy Sikora Department of Perinatology and Gynecology, Medical University of Silesia, Katowice, Poland

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Magdalena Olszanecka-Glinianowicz Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty of Silesia in Katowice, Medical University of Silesia, Katowice, Poland

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Introduction It has been shown that the levels of different adipokines, such as leptin, adiponectin, resistin, vaspin, omentin-1 and RBP4 are higher in women than those in men ( 1 , 2 , 3 , 4 , 5 , 6 ), and that estrogens stimulate

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Shilpa Lingaiah Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland

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Laure Morin-Papunen Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland

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Terhi Piltonen Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland

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Inger Sundström-Poromaa Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

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Elisabet Stener-Victorin Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

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Juha S Tapanainen Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, University of Oulu and Oulu University Hospital, Oulu, Finland
Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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pathogenesis of PCOS ( 5 , 6 , 7 ), it is not clear whether they have a direct association with PCOS. Adipose tissue acts as an endocrine organ secreting various adipokines including retinol-binding protein 4 (RBP4), which is mainly synthesised by hepatocytes

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Huguette S Brink Department of Endocrinology, Maasstad Hospital, Rotterdam, The Netherlands

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Aart Jan van der Lely Department of Endocrinology, Erasmus University MC, Rotterdam, The Netherlands

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Joke van der Linden Department of Endocrinology, Maasstad Hospital, Rotterdam, The Netherlands

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( 12 , 13 ). Hence, there is need to predict and detect GD earlier in pregnancy in order to limit the exposure to impaired glucose metabolism. Investigating the role of adipokines associated with the pathophysiology of GD has gained interest ( 14 , 15

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Jay Toulany College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada

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Sebastian D Parlee Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

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Christopher J Sinal Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada

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Kathryn Slayter Canadian Centre for Vaccinology, IWK Health Centre, Nova Scotia Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada

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Shelly McNeil Canadian Centre for Vaccinology, IWK Health Centre, Nova Scotia Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada

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Kerry B Goralski College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada

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Introduction After characterisation as an adipokine by our group in 2007, research concerning chemerin and its relationship to obesity has risen steadily. Chemerin is secreted as an inactive precursor prochemerin, which undergoes processing at

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Davoud Jafari-Gharabaghlou Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Mostafa Vaghari-Tabari Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Hajar Oghbaei Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran

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Laura Lotz Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany

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Reza Zarezadeh Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Yeganeh Rastgar Rezaei Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

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Mahnaz Ranjkesh Medical Radiation Science Research Group (MRSRG), Tabriz University of Medical Sciences, Tabriz, Iran

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Mohammad Nouri Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

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Amir Fattahi Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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Saba Nikanfar Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Ralf Dittrich Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany

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-like factors called adipokines. Adipokines are a kind of cytokine that contributes to energy metabolism, inflammation, immunity, and angiogenesis, as well as, reproductive maturity and fertility ( 6 , 7 , 8 , 9 ). Regarding the latter effect, it has been

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Ningning Gong Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
Department of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China

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Cuixia Gao Department of Ultrasonic Diagnosis, Gansu Provincial Hospital, Lanzhou, China

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Xuedi Chen Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Yu Wang Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Limin Tian Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China

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Lena-Maria Levin Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

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Henry Völzke Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
DZD (German Center for Diabetes Research), Greifswald, Germany

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Markus M Lerch Department of Medicine A, University Medicine Greifswald, Greifswald, Germany

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Jens-Peter Kühn Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
Institute and Policlinic for Radiology and Interventional Radiology, University Hospital, Carl-Gustav-Carus University Dresden, Dresden, Germany

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Matthias Nauck Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany

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Nele Friedrich Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany

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Stephanie Zylla Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany

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on the role of adipose tissue as an endocrine organ that produces a multitude of metabolically active hormones, so-called adipokines, which are known to be involved in the regulation of glucose and lipid metabolism, food intake and inflammation ( 4

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Jana Ernst Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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Urszula Grabiec Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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Kathrin Falk Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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Faramarz Dehghani Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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Kristina Schaedlich Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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-Golabi-Behmel Syndrome (SGBS) preadipocytes followed by investigating the impact of DEHP on the ECS as an endocrine modulator of the adipokine system. Materials and methods Chemicals DEHP was dissolved in dimethyl sulfoxide (DMSO), both purchased from Sigma

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