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Erika Peverelli, Federica Ermetici, Sabrina Corbetta, Ettore Gozzini, Laura Avagliano, Marco A Zappa, Gaetano Bulfamante, Paolo Beck-Peccoz, Anna Spada and Giovanna Mantovani

Introduction White adipose tissue (WAT) is mainly involved in energy storage and mobilization in the form of triglycerides, although a paracrine and endocrine function of white adipocytes has also been recognized. Excess of WAT results from an

Open access

Jana Ernst, Urszula Grabiec, Kathrin Falk, Faramarz Dehghani and Kristina Schaedlich

leptin and decreasing serum adiponectin ( 14 , 15 , 16 ). Accordingly, data from in vitro models showed a DEHP-dependent impairment of adipogenesis and adipocyte function ( 14 , 17 ). Analyses on underlying mechanisms are difficult, because energy

Open access

Sandrine Visentin, Gérard Michel, Claire Oudin, Béatrice Cousin, Bénédicte Gaborit, Inès Abdesselam, Marie Maraninchi, Marion Nowicki, René Valéro, Maxime Guye, Monique Bernard, Pascal Auquier, Hervé Chambost, Marie-Christine Alessi and Sophie Béliard

. Previous work by Cousin et al . reported that irradiation alters the proliferation and differentiation capacity of adipocyte precursor cells in mice ( 19 ). However, the effects of radiation exposure on human AT are unknown. No study to date had the

Open access

Michaela Keuper

substantiate the strong association between decreased mitochondrial content and oxygen consumption of WAT/adipocytes, which is in particular evident during metabolic complications such as insulin resistance, type 2 diabetes (T2DM) and cardiovascular diseases

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Hong-Fa Yan, Zhao-Yu Liu, Zhi-Ang Guan and Chuang Guo

demonstrated that excess iron in adipose tissue boosts adipose tissue dysfunction, resulting in decreased adipogenesis and enhanced adipocyte inflammation and adipose tissue macrophage infiltration ( 8 , 11 , 14 ). Consistently, iron overload has detrimental

Open access

Julie Smith, Jan Fahrenkrug, Henrik L Jørgensen, Christina Christoffersen and Jens P Goetze

-C, both expressed in several tissues including heart, kidney, vascular endothelium, and adipocytes. Thus, the endocrine heart is involved not only in hemodynamic regulation but also in energy homeostasis (7) . The sympathetic nervous system plays a key

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Florian W Kiefer

molecular mechanisms that are responsible for the energy-dissipating qualities of brown fat have been studied in detail ( 4 , 5 ). Uncoupling protein-1 (UCP-1) has been identified as the key factor controlling the thermogenic capacity of brown adipocytes

Open access

Lianghui You, Yan Wang, Yao Gao, Xingyun Wang, Xianwei Cui, Yanyan Zhang, Lingxia Pang, Chenbo Ji, Xirong Guo and Xia Chi

adipocyte differentiation and cold-mediated thermogenic activation. Other types of cold-regulated adipokines such as FGF21 ( 18 ) and apelin ( 19 ) have been also demonstrated to regulate Ucp1 expression and adaptive thermogenesis. Identification of

Open access

Huguette S Brink, Aart Jan van der Lely and Joke van der Linden

developing GD ( 25 ). The global increase in GD is largely attributed to the ongoing obesity pandemic ( 26 ). Obesity is characterized by altered production of proinflammatory cytokines by adipocytes causing a state of chronic low-grade inflammation ( 27

Open access

Chan Sub Park, Jihye Choi, Min-Ki Seong, Sung-Eun Hong, Jae-Sung Kim, In-Chul Park, Hyesil Seol, Woo Chul Noh and Hyun-Ah Kim

Introduction Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor (HR)-positive breast cancer. Although estradiol is produced mainly by the ovary in premenopausal women, the adrenal gland and adipocytes are also