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Solène Castellnou, Alexandre Vasiljevic, Véronique Lapras, Véronique Raverot, Eudeline Alix, Françoise Borson-Chazot, Emmanuel Jouanneau, Gérald Raverot and Hélène Lasolle

, 18 , 19 ). However, using immunohistochemistry (IHC), SST5 expression was only found in 20 to 55% of corticotroph tumors ( 20 , 21 , 22 ). Somatic driver mutations in the ubiquitin-specific protease 8 ( USP8 ) gene, identified in 35% to 60% of

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Paula Bruna Araujo, Leandro Kasuki, Carlos Henrique de Azeredo Lima, Liana Ogino, Aline H S Camacho, Leila Chimelli, Márta Korbonits and Monica R Gadelha

hormones and a normal pituitary MRI ( Fig. 1C ). This patient’s tissue sample has been tested negative for somatic ubiquitin-specific protease 8 (USP8) gene ( 30 ). No mutations were detected among patients with NFPA. There was no difference regarding age