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Annette Mouritsen Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Alexander Siegfried Busch Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Lise Aksglaede Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Ewa Rajpert-De Meyts Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Anders Juul Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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urine depends on sulfation and glucuronidation of steroids to water-soluble conjugates. One of the several essential glucuronidases is uridine diphosphate glucuronyltransferase 2B17, encoded by the UGT2B17 gene, and several studies observed a lower

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0080
Volume/Issue:
Volume 7: Issue 3
Open access
Nandini Shankara Narayana Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Lam P Ly Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Veena Jayadev Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Carolyn Fennell Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Sasha Savkovic Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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Ann J Conway Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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David J Handelsman Andrology Department, Concord Hospital and, ANZAC Research Institute, University of Sydney, Sydney, Australia

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diphospho-glucuronosyl transferase 2B17 (UGT2B17) polymorphism in testosterone glucuronidation rendering the steroid more hydrophilic for renal excretion ( 33 ). The UGT2B17 polymorphism primarily influences testosterone glucuronide excretion ( 34 ) but not

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0109
Volume/Issue:
Volume 10: Issue 7
Open access
Emma Jernberg Department of Medical biosciences, Umeå University, Umeå, Sweden

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Anders Bergh Department of Medical biosciences, Umeå University, Umeå, Sweden

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Pernilla Wikström Department of Medical biosciences, Umeå University, Umeå, Sweden

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levels to be associated with expression of certain canonical AR genes, such as UBE2C , CCNA2 , UGT2B17 and C-MYC , but not with others ( KLK3 , KLK2 , NKX3-1 , TMPRSS2 and FKBP5 ) ( 65 ). Many functional studies have been performed to evaluate

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0118
Volume/Issue:
Volume 6: Issue 8
Open access