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Xue-Lian Zhang Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Xinyi Zhao Department of Physiology, School of Medicine, Jinan University, Guangzhou, China

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Yong Wu Department of Physiology, School of Medicine, Jinan University, Guangzhou, China
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China

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Wen-qing Huang Department of Transfusion Medicine, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China

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Jun-jiang Chen Department of Physiology, School of Medicine, Jinan University, Guangzhou, China
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China

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Peijie Hu Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China

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Wei Liu Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Yi-Wen Chen Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Jin Hao Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Rong-Rong Xie Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Hsiao Chang Chan Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China

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Ye Chun Ruan Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China

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Hui Chen Cell-Gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

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Jinghui Guo Department of Physiology, School of Medicine, Jinan University, Guangzhou, China

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of ACE-2, angiotensin(1–7) (Ang(1–7)) and its receptor (MAS-1), which causes vasodilation and therefore counteracts the pressor arm ( 4 ). While the over-activated pressor arm causes a deleterious effect contributing to the end-organ damage in

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Sarah J Delforce School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Eugenie R Lumbers School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Celine Corbisier de Meaultsart School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Yu Wang Oregon Health and Science University, Portland, Oregon, USA

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Anthony Proietto Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia

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Geoffrey Otton Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia

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Jim Scurry Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia

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Nicole M Verrills School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia

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Rodney J Scott School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia

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Kirsty G Pringle School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Five micron thick FFPE sections affixed to slides were de-waxed and antigen retrieval for prorenin, ATP6AP2, ACE1, ACE2, AGT, AGTR1 and MAS1 was performed in 10 mM citrate buffer at pH 6.0 for 10 min using a microwave oven. Antigen retrieval for AGTR2

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