A J Varewijck
A J Varewijck
Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands
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A J van der Lely
A J van der Lely
Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands
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S J C M M Neggers
S J C M M Neggers
Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands
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S W J Lamberts
S W J Lamberts
Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands
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L J Hofland
L J Hofland
Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands
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J A M J L Janssen
J A M J L Janssen
Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands
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advantage of measuring the net effects of serum on IGF1R activation, as it does not ignore the modifying effects of IGFBPs, IGFBP proteases, and other factors that interact between IGFs and the IGF1R (3, 4) . One of these factors might be soluble Klotho (S-Klotho
Mohammed S Razzaque
Mohammed S Razzaque
Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania, USA
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Nabeshima Y . Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system . Molecular Endocrinology 2003 17 2393 – 2403 . ( https://doi.org/10.1210/me.2003-0048 ) 9
Shu-Meng Hu
Shu-Meng Hu
Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Yang-Juan Bai
Yang-Juan Bai
Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Ya-Mei Li
Ya-Mei Li
Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Ye Tao
Ye Tao
Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Xian-Ding Wang
Xian-Ding Wang
Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Tao Lin
Tao Lin
Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Lan-Lan Wang
Lan-Lan Wang
Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Yun-Ying Shi
Yun-Ying Shi
Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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phosphate ( 5 ). alpha Klotho (KLA) is a newly discovered antiaging protein mainly synthesized by kidney distal convoluted tubules and excreted by glomerular filtration ( 6 ). While the binding affinity of FGF23 to FGFR1 is rather low, KLA can significantly
Wenqi Yang
Wenqi Yang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Ling Liu
Ling Liu
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Yuan Wei
Yuan Wei
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
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Chunlu Fang
Chunlu Fang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
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Fu Zhou
Fu Zhou
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Jinbao Chen
Jinbao Chen
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qinghua Han
Qinghua Han
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Meifang Huang
Meifang Huang
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Xuan Tan
Xuan Tan
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qiuyue Liu
Qiuyue Liu
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qiang Pan
Qiang Pan
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Lu Zhang
Lu Zhang
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Xiaojuan Lei
Xiaojuan Lei
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Liangming Li
Liangming Li
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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). FGF21 exerts its biological actions through binding to FGF receptors (FGFRs) and an essential co-receptor, β-klotho ( 7 ), forming the FGF21 receptor complex. FGF21 is produced predominantly in the liver ( 4 , 8 ). Adipose tissue is a primary target
Martine Cohen-Solal
Martine Cohen-Solal
Department of Skeletal Diseases, INSERM U1132 & Université de Paris, Hôpital Lariboisière, Paris, France
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Thomas Funck-Brentano
Thomas Funck-Brentano
Department of Skeletal Diseases, INSERM U1132 & Université de Paris, Hôpital Lariboisière, Paris, France
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Pablo Ureña Torres
Pablo Ureña Torres
AURA Nord, Saint Ouen, France
Department of Renal Physiology, Necker Hospital, Université de Paris, Paris, France
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Department of Renal Physiology, Necker Hospital, Université de Paris, Paris, France
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). Accordingly, parathyroidectomy reduces bone turnover, improves BMD and reduces long-term risk for fractures, as observed in CKD stage 5D patients ( 48 , 49 , 50 ). The phosphate/FGF23/Klotho axis The skeleton is the main storage site and one of the
Julie Refardt
Julie Refardt
Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Clara Odilia Sailer
Clara Odilia Sailer
Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Bettina Winzeler
Bettina Winzeler
Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Matthias Johannes Betz
Matthias Johannes Betz
Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Irina Chifu
Irina Chifu
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Ingeborg Schnyder
Ingeborg Schnyder
Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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Martin Fassnacht
Martin Fassnacht
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Central Laboratory, University Hospital Würzburg, Würzburg, Germany
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Central Laboratory, University Hospital Würzburg, Würzburg, Germany
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Wiebke Fenske
Wiebke Fenske
Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
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Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
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Mirjam Christ-Crain
Mirjam Christ-Crain
Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel, Basel, Switzerland
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for the CODDI-Investigators
for the CODDI-Investigators
for the CODDI-Investigators
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Murakami M Moriyama T Yamauchi-Takihara K. Klotho-related molecules upregulated by smoking habit in apparently healthy men: a cross-sectional study . Scientific Reports 2015 5 14230 . (doi:10.1038/srep14230) 11 Nakanishi K Nishida M Yamamoto R
Julie M Silverstein
Julie M Silverstein
Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8127, St Louis, Missouri 63110, USA
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be useful in the monitoring of patients. Recent studies have identified a new serum biomarker that could potentially be used to complement GH and IGF1 as indicators of active acromegaly. Excessive levels of soluble Klotho (sKlotho) have been observed
Magdaléna Fořtová
Magdaléna Fořtová
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Lenka Hanousková
Lenka Hanousková
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Martin Valkus
Martin Valkus
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Jana Čepová
Jana Čepová
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Richard Průša
Richard Průša
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Karel Kotaška
Karel Kotaška
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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. Regulation and function of the FGF23/klotho endocrine pathways . Physiological Reviews 2012 92 131 – 155 . ( https://doi.org/10.1152/physrev.00002.2011 ) 13 Isakova T Xie H Barchi-Chung A Vargas G Sowden N Houston J Wahl P Lundquist A
Vickie Braithwaite
Vickie Braithwaite
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Kerry S Jones
Kerry S Jones
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Shima Assar
Shima Assar
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Inez Schoenmakers
Inez Schoenmakers
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Ann Prentice
Ann Prentice
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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co-receptor α-Klotho (4) binds to the FGF receptor (FGFR) to initiate the internalisation of sodium P transporters NaPi-2a (SLC34A1) and NaPi-2c (SLC34A3) (5) . In diseased states where FGF23 concentration is elevated, the net result is an
Peiwen Zheng
Peiwen Zheng
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Fan Wang
Fan Wang
Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China
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Hui Li
Hui Li
Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot, China
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Hanlu Chen
Hanlu Chen
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Mengtong Li
Mengtong Li
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Haozheng Ma
Haozheng Ma
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Jue He
Jue He
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Li Chen
Li Chen
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Yanlong Liu
Yanlong Liu
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Haiyun Xu
Haiyun Xu
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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are elevated in various metabolic diseases, such as obesity, insulin resistance, and type 2 diabetes mellitus ( 67 , 68 ). In addition, serum concentrations of FGF21, soluble α-klotho, and interleukin 6 are significantly higher in male smokers
