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Masafumi Tetsuka and Misato Tanakadate

, 9 , 10 , 11 , 12 ). Recently, we have demonstrated that the bovine oocyte cumulus complex (COC) undergoing IVM expresses two types of glucocorticoid metabolizing enzymes, namely 11β-hydroxysteroid oxidoreductase type1 (HSD11B1) and type2 (HSD11B

Open access

Janko Sattler, Jinwen Tu, Shihani Stoner, Jingbao Li, Frank Buttgereit, Markus J Seibel, Hong Zhou, and Mark S Cooper

, mice with transgenic deletion of Hsd11b1 , at least on some genetic backgrounds, show an increase in the circulating level of corticosterone ( 17 , 18 ). It is thus possible that the failure of the HPA axis to be activated in chronic arthritis could

Open access

A Daniel Bird, Spencer Greatorex, David Reser, Gareth G Lavery, and Timothy J Cole

‘GXXXGXG’ nucleotide cofactor (NAD + /NADP + ) binding domain and an ‘YXXXK’ catalytic active site domain ( 4 ). 11βHSD1 and 11βHSD2 carry out largely opposing roles in the preceptor modification of corticosteroids. 11βHSD1, encoded by the HSD11B1 gene

Open access

Jana Ernst, Katharina Gert, Frank Bernhard Kraus, Ulrike Elisabeth Rolle-Kampczyk, Martin Wabitsch, Faramarz Dehghani, and Kristina Schaedlich

) as housekeeping gene was determined for the following genes: AR , CYP11A1 , CYP17A1 , CYP19, ER#x03B1; , ERβ , GLUT4 , GPER , GR , HSD3B , HSD11B1 , HSD17B5 , PGR and StAR . The specifications of primers and amplicons are given in Table

Open access

Xingyan Liu, Mei Xu, Min Qian, and Lindong Yang

Theoretical Biology 2013 332 52 – 64 . ( ) 13 Chua AK Azziz R Goodarzi MO . Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage . Molecular Human

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Yiyan Wang, Yaoyao Dong, Yinghui Fang, Yao Lv, Qiqi Zhu, Xiaoheng Li, Qingquan Lian, and Ren-Shan Ge

HSD11B1 and HSD11B2 ( 34 ), there is very limited information on placental HSD11B2 inhibitors. One HSD11B2 inhibitor is the metabolite of methoxychlor, 2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) ( 35 ). In the present study, we presented

Open access

Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather M Stapleton, and Heather B Patisaul

selectin P ( Selp ). Similarly, placental upregulation of both 11-β-hydroxysteroid dehydrogenase 1 and 2 ( Hsd11b1 and Hsd11b2 ), which are responsible for the inactivation of maternal cortisol ( 80 ), was observed in the high-dose group, providing