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mMDEGs are shown in Fig. 3C and D . For the KEGG pathway analysis, it was found that mMDEGs were significantly associated with the ‘T2D’ signaling pathway ( Fig. 3E ). The mMDEGs participating in this pathway were INS , MAFA , and HK2 . Thus, in
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control, and black bars, T 3 -administered groups. # P < 0.05 compared to the euthyroid group. T 3 treatment does not modulate Hk2 mRNA, but increases HK2 protein It is well known that thyroid hormones exert their functions mainly
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67 (ab16667, Abcam), P53 (ab32389, Abcam), matrix metallopeptidase 9 (MMP9; ab219372, Abcam), hexokinase 2 (HK-2; ab104836, Abcam), TNFAIP8 (ab195810, Abcam) and β-actin (ab8226, Abcam). The PVDF membrane was probed with the secondary antibody (ab
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pharmacologic activities, including anti-allergic, anti-inflammatory, and antitumor activities ( 93 ). Studies have shown that PD can up-regulate the expression of GPX4 to inhibit HG-induced ferroptosis in HK-2 cells, suggesting that PD may be helpful in the
Department of Science and Environment, Roskilde University, Roskilde, Denmark
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Department of Clinical Immunology, Næstved Hospital, Næstved, Denmark
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-Junior DC Gerlinger-Romero F Enguita FJ MacHado UF Diabetes modulates microRNAs 29b-3p, 29c-3p, 199a-5p and 532–3p expression in muscle: possible role in GLUT4 and HK2 repression . Frontiers in Endocrinology 2018 9 536. ( https://doi.org/10