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Rachel D C A Diniz, Renata M Souza, Roberto Salvatori, Alex Franca, Elenilde Gomes-Santos, Thiago O Ferrão, Carla R P Oliveira, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Rossana M C Pereira, Alécia A Oliveira-Santos, Allysson M P Silva, Francisco J Santana-Júnior, Eugênia H O Valença, Viviane C Campos and Manuel H Aguiar-Oliveira

hepatocellular carcinoma is higher than 10% in 5 years (6) . It is therefore important to define the causes of NAFLD. Adult-onset GH deficiency (AOGHD) constitutes a specific model of metabolic syndrome (7, 8) , with visceral obesity, insulin resistance

Open access

Esben Thyssen Vestergaard, Morten B Krag, Morten M Poulsen, Steen B Pedersen, Niels Moller, Jens Otto Lunde Jorgensen and Niels Jessen

Introduction GH release from the pituitary gland is considered to be regulated at the hypothalamic level by GH releasing hormone (GHRH) and somatostatin (1) . More recently, ghrelin, an endogenous ligand of the GH secretagogue receptor (GHS-R), has

Open access

Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen and on behalf of the Growth Hormone Research Society

). The requirement for rigorous procedures utilizing biomarkers in drug development is evident and recognized ( 2 , 5 ). The obvious biomarkers of growth hormone (GH) action in children and adults are serum levels of GH itself and of insulin-like growth

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Guillem Cuatrecasas, Hatice Kumru, M Josep Coves and Joan Vidal

( 3 ). Some case report was published ( 7 ) and the work done in transitional rodent models ( 8 , 9 , 10 ) focused our attention on the potential of GH for neurologic improvement in SCI. However, in humans, very little is known about GH deficiency in

Open access

Charlotte Höybye, Erik Wahlström, Petra Tollet-Egnell and Gunnar Norstedt

(3) . Adult growth hormone deficiency (GHD) syndrome is a well-defined clinical entity, including abnormal body composition, poor quality of life, dyslipidaemia and increased cardiovascular risk and mortality (4, 5) . GH has systematically been given

Open access

Kathryn L Gatford, Beverly S Muhlhausler, Lili Huang, Pamela Su-Lin Sim, Claire T Roberts, Johannes D Velhuis and Chen Chen

Introduction Successful pregnancy requires major physiological adaptations in the mother to support pregnancy, and the attachment, implantation, growth and function of the placental interface between mother and foetus ( 1 ). Growth hormone (GH

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Pinaki Dutta, Bhuvanesh Mahendran, K Shrinivas Reddy, Jasmina Ahluwalia, Kim Vaiphei, Rakesh K Kochhar, Prakamya Gupta, Anand Srinivasan, Mahesh Prakash, Kanchan Kumar Mukherjee, Viral N Shah, Girish Parthan and Anil Bhansali

Introduction Acromegaly is most commonly caused by a growth hormone (GH)-producing pituitary tumor and is potentially life-threatening if untreated. Early diagnosis and treatment of acromegaly result in increased longevity and better quality of life

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Charlotte Höybye, Andreas F H Pfeiffer, Diego Ferone, Jens Sandahl Christiansen, David Gilfoyle, Eva Dam Christoffersen, Eva Mortensen, Jonathan A Leff and Michael Beckert

Introduction Hypothalamic–pituitary diseases and/or injury can lead to adult growth hormone deficiency (AGHD) ( 1 ). The decrease (or total loss) of growth hormone (GH) production, with a subsequent disruption in the hormone’s relationship

Open access

Elvira C Arellanes-Licea, José Ávila-Mendoza, Elizabeth C Ramírez-Martínez, Eugenia Ramos, Nancy Uribe-González, Carlos Arámburo, Teresa Morales and Maricela Luna

( 7 ) in sensitive zones with high glutamate receptor concentration such as the hippocampus ( 8 , 9 ). Lactation is characterized by fluctuation of several hormones including growth hormone (GH) ( 10 ). GH is secreted mainly by the anterior

Open access

Ursula M M Costa, Carla R P Oliveira, Roberto Salvatori, José A S Barreto-Filho, Viviane C Campos, Francielle T Oliveira, Ivina E S Rocha, Joselina L M Oliveira, Wersley A Silva and Manuel H Aguiar-Oliveira

Introduction Growth hormone (GH) and its principal mediator insulin-like growth factor 1 (IGF1) have important effects not only on the acquisition of normal body size, but also on metabolic and cardiovascular (CV) status (1) . GH and IGF1 have