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Ananda A Santana-Ribeiro, Giulliani A Moreira-Brasileiro, Manuel H Aguiar-Oliveira, Roberto Salvatori, Vitor O Carvalho, Claudia K Alvim-Pereira, Carlos R Araújo-Daniel, Júlia G Reis-Costa, Alana L Andrade-Guimarães, Alécia A Oliveira-Santos, Edgar R Vieira and Miburge B Gois-Junior

affect walking and postural balance. Mice with reduced GH signaling have better physical capacity than normal animals ( 11 ). It is unclear if humans with isolated GH deficiency (IGHD) in combination with reduced body size have adequate walking and

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Taísa A R Vicente, Ívina E S Rocha, Roberto Salvatori, Carla R P Oliveira, Rossana M C Pereira, Anita H O Souza, Viviane C Campos, Elenilde G Santos, Rachel D C Araújo Diniz, Eugênia H O Valença, Carlos C Epitácio-Pereira, Mario C P Oliveira, Andrea Mari and Manuel H Aguiar-Oliveira

. ( doi:10.1210/jc.84.3.917 ). 10 Aguiar-Oliveira MH Gill MS de A Barretto ES Alcântara MR Miraki-Moud F Menezes CA Souza AH Martinelli CE Pereira FA Salvatori R . Effect of severe growth hormone (GH) deficiency due to a mutation

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Guillem Cuatrecasas, Hatice Kumru, M Josep Coves and Joan Vidal

( 3 ). Some case report was published ( 7 ) and the work done in transitional rodent models ( 8 , 9 , 10 ) focused our attention on the potential of GH for neurologic improvement in SCI. However, in humans, very little is known about GH deficiency in

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Rachel D C A Diniz, Renata M Souza, Roberto Salvatori, Alex Franca, Elenilde Gomes-Santos, Thiago O Ferrão, Carla R P Oliveira, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Rossana M C Pereira, Alécia A Oliveira-Santos, Allysson M P Silva, Francisco J Santana-Júnior, Eugênia H O Valença, Viviane C Campos and Manuel H Aguiar-Oliveira

hepatocellular carcinoma is higher than 10% in 5 years (6) . It is therefore important to define the causes of NAFLD. Adult-onset GH deficiency (AOGHD) constitutes a specific model of metabolic syndrome (7, 8) , with visceral obesity, insulin resistance

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Ursula M M Costa, Carla R P Oliveira, Roberto Salvatori, José A S Barreto-Filho, Viviane C Campos, Francielle T Oliveira, Ivina E S Rocha, Joselina L M Oliveira, Wersley A Silva and Manuel H Aguiar-Oliveira

synergistic anabolic effect on muscle mass, but antagonist effects on insulin action (GH-reducing and IGF1 increasing insulin sensitivity) and lipolysis (GH increasing and IGF1 reducing it) (2) . Adult onset GH deficiency (GHD) has been described as model of

Open access

Charlotte Höybye, Erik Wahlström, Petra Tollet-Egnell and Gunnar Norstedt

individuals. The metabolic and anthropometric characteristics of the controls are given in Table 2 . Table 2 Metabolic and anthropometric characteristics (mean± s.d. ) of ten healthy controls and ten patients with growth hormone (GH) deficiency at baseline

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Pinaki Dutta, Bhuvanesh Mahendran, K Shrinivas Reddy, Jasmina Ahluwalia, Kim Vaiphei, Rakesh K Kochhar, Prakamya Gupta, Anand Srinivasan, Mahesh Prakash, Kanchan Kumar Mukherjee, Viral N Shah, Girish Parthan and Anil Bhansali

(QoL) (1) . However, successful treatment of acromegaly either by surgery, radiation or combinations of different treatment modalities results in GH deficiency (GHD) in nearly 30–60% of patients (2, 3) . The prevalence of GHD increases as the duration

Open access

Charlotte Höybye, Andreas F H Pfeiffer, Diego Ferone, Jens Sandahl Christiansen, David Gilfoyle, Eva Dam Christoffersen, Eva Mortensen, Jonathan A Leff and Michael Beckert

compared to Omnitrope at equivalent weekly dosing. IGF1 exposure after equivalent dosing of TransCon GH and Omnitrope was also similar. AGHD is associated with increased mortality, mainly due to cardiovascular risk. GH deficiency contributes to visceral

Open access

Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen and on behalf of the Growth Hormone Research Society

factor-I (IGF-I). Both are used diagnostically; IGF-I is used to monitor the effects of GH replacement in GH deficiency (GHD), and both GH and IGF-I are used in the diagnosis and management of acromegaly. While serum IGF-I level is used as a surrogate

Open access

Marilena Nakaguma, Fernanda A Correa, Lucas S Santana, Anna F F Benedetti, Ricardo V Perez, Martha K P Huayllas, Mirta B Miras, Mariana F A Funari, Antonio M Lerario, Berenice B Mendonca, Luciani R S Carvalho, Alexander A L Jorge and Ivo J P Arnhold

reported in a large kindred with isolated GH deficiency from Itabaianinha in Northeastern Brazil ( 8 ). The same variant in homozygous and compound heterozygous state was also previously described in other Brazilian familial and sporadic cases and a founder