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Taísa A R Vicente, Ívina E S Rocha, Roberto Salvatori, Carla R P Oliveira, Rossana M C Pereira, Anita H O Souza, Viviane C Campos, Elenilde G Santos, Rachel D C Araújo Diniz, Eugênia H O Valença, Carlos C Epitácio-Pereira, Mario C P Oliveira, Andrea Mari and Manuel H Aguiar-Oliveira

. ( doi:10.1210/jc.84.3.917 ). 10 Aguiar-Oliveira MH Gill MS de A Barretto ES Alcântara MR Miraki-Moud F Menezes CA Souza AH Martinelli CE Pereira FA Salvatori R . Effect of severe growth hormone (GH) deficiency due to a mutation

Open access

Guillem Cuatrecasas, Hatice Kumru, M Josep Coves and Joan Vidal

( 3 ). Some case report was published ( 7 ) and the work done in transitional rodent models ( 8 , 9 , 10 ) focused our attention on the potential of GH for neurologic improvement in SCI. However, in humans, very little is known about GH deficiency in

Open access

Rachel D C A Diniz, Renata M Souza, Roberto Salvatori, Alex Franca, Elenilde Gomes-Santos, Thiago O Ferrão, Carla R P Oliveira, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Rossana M C Pereira, Alécia A Oliveira-Santos, Allysson M P Silva, Francisco J Santana-Júnior, Eugênia H O Valença, Viviane C Campos and Manuel H Aguiar-Oliveira

hepatocellular carcinoma is higher than 10% in 5 years (6) . It is therefore important to define the causes of NAFLD. Adult-onset GH deficiency (AOGHD) constitutes a specific model of metabolic syndrome (7, 8) , with visceral obesity, insulin resistance

Open access

Ursula M M Costa, Carla R P Oliveira, Roberto Salvatori, José A S Barreto-Filho, Viviane C Campos, Francielle T Oliveira, Ivina E S Rocha, Joselina L M Oliveira, Wersley A Silva and Manuel H Aguiar-Oliveira

synergistic anabolic effect on muscle mass, but antagonist effects on insulin action (GH-reducing and IGF1 increasing insulin sensitivity) and lipolysis (GH increasing and IGF1 reducing it) (2) . Adult onset GH deficiency (GHD) has been described as model of

Open access

Charlotte Höybye, Erik Wahlström, Petra Tollet-Egnell and Gunnar Norstedt

individuals. The metabolic and anthropometric characteristics of the controls are given in Table 2 . Table 2 Metabolic and anthropometric characteristics (mean± s.d. ) of ten healthy controls and ten patients with growth hormone (GH) deficiency at baseline

Open access

Pinaki Dutta, Bhuvanesh Mahendran, K Shrinivas Reddy, Jasmina Ahluwalia, Kim Vaiphei, Rakesh K Kochhar, Prakamya Gupta, Anand Srinivasan, Mahesh Prakash, Kanchan Kumar Mukherjee, Viral N Shah, Girish Parthan and Anil Bhansali

(QoL) (1) . However, successful treatment of acromegaly either by surgery, radiation or combinations of different treatment modalities results in GH deficiency (GHD) in nearly 30–60% of patients (2, 3) . The prevalence of GHD increases as the duration

Open access

Ananda A Santana-Ribeiro, Giulliani A Moreira-Brasileiro, Manuel H Aguiar-Oliveira, Roberto Salvatori, Victor Carvalho, Claudia K Alvim-Pereira, Carlos R Araújo-Daniel, Julia G Reis-Costa, Alana L Andrade-Guimarães, Alecia Ao Santos, Edgard R Vieira and Miburge B Gois-Junior

Objectives: Walking and postural balance are extremely important to obtain food and to work. Both are critical for quality of life and ability to survive. While walking reflects musculoskeletal and cardiopulmonary systems, postural balance depends on body size, muscle tone, visual, vestibular, and nervous systems. Since GH and IGF-I act on all these systems, we decided to study those parameters in a cohort of individuals with severe short stature due to untreated isolated GH deficiency (IGHD) caused by a mutation in the GHRH receptor gene. These IGHD subjects despite reduction in muscle mass, are very active and have normal longevity.

Methods: In a cross-sectional study we assessed walking (by a 6-minute walk test), postural balance (by force platform) and falls risk (by the timed Up and Go test) in 31 IGHD and 40 matched health controls.

Results: The percentage of the walked measured distance in relation to the predicted one was similar in groups, but higher in IGHD, when corrected by the leg length. Absolute postural balance data showed similar velocity of unipodal support in the two groups, and better values, with open and closed eyes and unipodal support, in IGHD. Most differences in postural balance became non-significant when corrected for height and lower limb length. The time in timed up and go test was higher in IGHD, but still below of the cut off value falls risk.

Conclusion: IGHD subjects showed normal or better walking and similar postural balance, without increase in falls risk.

Open access

Charlotte Höybye, Andreas F H Pfeiffer, Diego Ferone, Jens Sandahl Christiansen, David Gilfoyle, Eva Dam Christoffersen, Eva Mortensen, Jonathan A Leff and Michael Beckert

compared to Omnitrope at equivalent weekly dosing. IGF1 exposure after equivalent dosing of TransCon GH and Omnitrope was also similar. AGHD is associated with increased mortality, mainly due to cardiovascular risk. GH deficiency contributes to visceral

Open access

Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen and on behalf of the Growth Hormone Research Society

factor-I (IGF-I). Both are used diagnostically; IGF-I is used to monitor the effects of GH replacement in GH deficiency (GHD), and both GH and IGF-I are used in the diagnosis and management of acromegaly. While serum IGF-I level is used as a surrogate

Open access

Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Giustino Orlando, Michele Vacca, Roberto Salvatori and Luigi Brunetti

lack the decline in cognitive ability in the Morris water maze test that is observed in WT mice ( 9 , 10 ). GHRHKO mice represent an animal model of isolated GH deficiency with otherwise normal pituitary function ( 11 ). We have recently demonstrated