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Adrian F Daly, David A Cano, Eva Venegas-Moreno, Patrick Petrossians, Elena Dios, Emilie Castermans, Alvaro Flores-Martínez, Vincent Bours, Albert Beckers and Alfonso Soto-Moreno

-to-treat pituitary adenomas ( 9 , 10 , 11 ). Germline AIP mutations ( AIP mut) or deletions generally predispose to acromegaly, usually presenting as familial isolated pituitary adenomas (FIPA) ( 12 ). Notably, AIP mut-associated somatotropinomas occur at a

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Adrian F Daly, Liliya Rostomyan, Daniela Betea, Jean-François Bonneville, Chiara Villa, Natalia S Pellegata, Beatrice Waser, Jean-Claude Reubi, Catherine Waeber Stephan, Emanuel Christ and Albert Beckers

pituitary adenoma (FIPA) kindreds and young patients, reaching nearly 30% in those with pituitary gigantism ( 8 ). AIP mutations confer a series of important aggressive characteristics in acromegaly. As compared with non-mutated acromegaly patients, those

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Marko Stojanovic, Zida Wu, Craig E Stiles, Dragana Miljic, Ivan Soldatovic, Sandra Pekic, Mirjana Doknic, Milan Petakov, Vera Popovic, Christian Strasburger and Márta Korbonits

adherens junction ( 10 , 15 ). AIP mutations were found in 20% of patients with familial isolated pituitary adenoma (FIPA) and in 25% of sporadic somatotropinomas of childhood onset ( 16 , 17 ). Most often these are invasive GH- or PRL

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Paula Bruna Araujo, Leandro Kasuki, Carlos Henrique de Azeredo Lima, Liana Ogino, Aline H S Camacho, Leila Chimelli, Márta Korbonits and Monica R Gadelha

hydrocarbon receptor-interacting protein ( AIP ) gene mutations ( AIPmut ) were first described by Vierimaa and coworkers in 2006 ( 3 ). This study has found AIPmut in seemingly sporadic acromegaly patients and in familial isolated pituitary adenomas (FIPA

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Anna-Pauliina Iivonen, Johanna Känsäkoski, Atte Karppinen, Leena Kivipelto, Camilla Schalin-Jäntti, Auli Karhu and Taneli Raivio

– 374 . ( https://doi.org/10.1016/j.ecl.2017.01.004 ) 10.1016/j.ecl.2017.01.004 28476226 7 Beckers A Aaltonen LA Daly AF Karhu A. Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl