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Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
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Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
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Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
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similarities with known neurotoxicants and endocrine-disrupting chemicals (EDCs), including PBDEs ( 9 ) and organophosphate pesticides ( 10 ), have raised concerns regarding possible health impacts, especially on the developing brain. Because we have found
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
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(EDC) as an exogenous chemical, or mixture that interferes with any aspect of hormone action ( 51 ). This differs somewhat from the toxicological definition of an EDC which adds the additional requirement that exposure must cause adverse effects in an
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certain endocrine-disrupting chemicals (EDCs). Numerous EDCs are present in our environment, and EDCs are suspected of playing a role in testicular dysgenesis syndrome (TDS) in humans. This syndrome encompasses a range of male disorders, presumed to have
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, Denmark
Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), University of Copenhagen, Rigshospitalet, Denmark
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Introduction Human male infertility is a common problem worldwide ( 1 ). The causes are in many cases unknown, but exposure to endocrine disrupting chemicals (EDCs) has been suspected to be involved ( 2 , 3 ). Sperm cell dysfunction is a
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EHESP-School of Public Health, Rennes, France
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Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France
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Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore, in this review, we discuss three recent reports that collectively indicate that prenatal exposure in a period of 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health. The combined data show that the exposure results in the reduction of primordial follicles, irregular menstrual cycle, premature absence of corpus luteum, as well as reduced fertility, resembling premature ovarian insufficiency syndrome in humans that is linked to premature menopause. This could especially affect the Western parts of the world, where the age for childbirth is continuously being increased and acetaminophen is recommended during pregnancy for pain and fever. We therefore highlight an urgent need for more studies to verify these data including both experimental and epidemiological approaches.
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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well as in exposure to endocrine-disrupting chemicals (EDCs). Several studies have been able to associate urinary levels of several EDCs, with the age at pubertal onset ( 5 , 6 ). Especially non-persistent phthalates and phenols have been investigated
Pritzker School of Medicine, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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Committee on Molecular Pathogenesis and Molecular Medicine, Chicago, Illinois, USA
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University of Chicago, Chicago, Illinois, USA
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in a diet enriched in saturated and trans fats as well as simple carbohydrates that promote the development of obesity and diabetes ( 7 , 8 ). Recently, exposures to endocrine-disrupting chemicals (EDCs) have been implicated as novel metabolic
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Asian women ( 51 , 82 ). Hence, while some of these foods are protective against endometriosis, heavy metal contamination in some of these products may counter their beneficial effects. Endocrine-disrupting chemicals (EDCs), which are ubiquitous in
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, benomyl, and mancozeb Pyrethroids , such as permethrin Triazines , such as atrazine Many pesticides are known to be endocrine-disrupting chemicals (EDCs), defined as ‘exogenous agents, that are potentially capable of synthesis, secretion
Fondazione Italiana Ricerca sulle Malattie dell’Osso (FIRMO Onlus), Florence, Italy
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such as phthalates, called ‘endocrine disruptor chemicals’ (EDCs), could be associated with a reduction in vitamin D levels ( 15 , 16 ). In a study by Johns et al. , involving 4667 adults who participated in the National Health and Nutrition