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M S Elston, V B Crawford, M Swarbrick, M S Dray, M Head and J V Conaglen

* Died shortly after first dose. AdenoCa, prostate adenocarcinoma; CS, Cushing’s syndrome; dx, diagnosis; hx, history; MR, mineralocorticoid. Of the reported cases of CS associated with SCPC most are due to ectopic ACTH production ( 24

Open access

Boni Xiang, Ran Tao, Xinhua Liu, Xiaoming Zhu, Min He, Zengyi Ma, Yehong Yang, Zhaoyun Zhang, Yiming Li, Zhenwei Yao, Yongfei Wang and Hongying Ye

Introduction Cushing’s syndrome (CS) comprises diverse manifestations resulting from chronic exposure to excess glucocorticoids. The incidence is 0.2–5.0 per million people per year. Approximately 80% of endogenous CS is adrenocorticotrophin

Open access

Soraya Puglisi, Paola Perotti, Mattia Barbot, Paolo Cosio, Carla Scaroni, Antonio Stigliano, Pina Lardo, Valentina Morelli, Elisa Polledri, Iacopo Chiodini, Giuseppe Reimondo, Anna Pia and Massimo Terzolo

Introduction Cushing’s syndrome (CS) is a condition of endogenous hypercortisolism caused by different pathological entities that is classified in two variants: (i) ACTH-dependent CS, due to a corticotroph pituitary adenoma or an ectopic tumor

Open access

Jingya Zhou, Meng Zhang, Lin Lu, Xiaopeng Guo, Lu Gao, Weigang Yan, Haiyu Pang, Yi Wang and Bing Xing

Introduction Endogenous Cushing’s syndrome (CS) comprises signs and symptoms caused by pathological hypercortisolism, which seriously affects the metabolic and endocrine systems. Endogenous CS is divided between adrenocorticotropic hormone

Open access

Benedetta Zampetti, Erika Grossrubatscher, Paolo Dalino Ciaramella, Edoardo Boccardi and Paola Loli

ACTH-dependent hypercortisolism is highly suggestive of pituitary disease, this is not true for smaller lesions that still might be incidentaloma ( 16 , 17 ). The Consensus Statement on Diagnosis and Complications of Cushing’s Syndrome suggests 6mm as

Open access

Majunath R Goroshi, Swati S Jadhav, Anurag R Lila, Rajeev Kasaliwal, Shruti Khare, Chaitanya G Yerawar, Priya Hira, Uday Phadke, Hina Shah, Vikram R Lele, Gaurav Malhotra, Tushar Bandgar and Nalini S Shah

Introduction Ectopic adrenocorticotrophic hormone (ACTH) syndrome (EAS) is a rare disorder, accounting for 5–15% cases of endogenous Cushing’s syndrome (CS) ( 1 , 2 ). Although initially construed to be caused by malignant tumours (such as

Open access

Kush Dev Singh Jarial, Anil Bhansali, Vivek Gupta, Paramjeet Singh, Kanchan K Mukherjee, Akhilesh Sharma, Rakesh K Vashishtha, Suja P Sukumar, Naresh Sachdeva and Rama Walia

Introduction The differential diagnosis of ACTH-dependent Cushing’s syndrome (CS) as pituitary or ectopic source of ACTH production is often challenging for the physicians as none of the biochemical tests or imaging modalities have 100

Open access

Alberto Giacinto Ambrogio, Massimiliano Andrioli, Martina De Martin, Francesco Cavagnini and Francesca Pecori Giraldi

Pathophysiology of the Hypothalamic-Pituitary-Adrenal Axis. Diagnosis and management of Cushing’s syndrome: results of an Italian multicentre study . Journal of Clinical Endocrinology and Metabolism 1999 84 440 – 448 . ( doi:10.1210/jcem.84.2.5465 ) 5

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Peter Wolf, Yvonne Winhofer, Martin Krššák and Michael Krebs

in patients suffering from Cushing’s syndrome. Even in long-term follow-up many years after complete cure of hypercortisolism, cardiovascular risk is still increased ( 72 ). In parts, increased cardiovascular mortality is mediated due to common

Open access

Andrea V Haas, Paul N Hopkins, Nancy J Brown, Luminita H Pojoga, Jonathan S Williams, Gail K Adler and Gordon H Williams

Introduction It is well established that individuals with Cushing’s syndrome, a disease of excess glucocorticoid production, have increased rates of hypertension, obesity, type 2 diabetes and cardiovascular (CV) events ( 1 ). Likewise