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Lauren E Henke, John D Pfeifer, Thomas J Baranski, Todd DeWees and Perry W Grigsby

are mutations in the BRAF gene. Occurring in approximately 50% of PTC patients, the BRAF mutation causes constitutive activation of the MAP-kinase pathway, leading to increased propensity for tumor cell proliferation ( 16 , 17 ). Although the

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Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi and Lewis Hassell

pathogenesis in PTC. Several genetic alterations have been described in PTC ( 4 ). Among them, BRAF mutation, especially BRAF V600E , is the most common mutation in PTC; however, its prognostic role in PTC is still debated ( 5 , 6 , 7 ). Another recently

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Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh and Tetsuo Kondo

considerable amount of between-study heterogeneity was present in only a few analyses (lymph node metastasis, pT factor and patient death). The difference in genetic backgrounds between TCVPTC, PTC-TCF and classical PTC Data for BRAF mutation were

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Barbora Pekova, Sarka Dvorakova, Vlasta Sykorova, Gabriela Vacinova, Eliska Vaclavikova, Jitka Moravcova, Rami Katra, Petr Vlcek, Pavla Sykorova, Daniela Kodetova, Josef Vcelak and Bela Bendlova

samples. In BRAF positive patients the mean age at the time of diagnosis was significantly higher than in RET/PTC positive patients ( P  = 0.012). The BRAF mutation also correlates with the classical variant of PTC ( P  < 0.001). The number of

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Guoquan Zhu, Yuying Deng, Liqin Pan, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang, Yanying Chen and Jiaxin Luo

constitutive activation of the mitogen-activated protein kinase (MAPK) signaling transduction pathway ( 12 ). In addition, some studies have demonstrated a strong association between the BRAF mutation and both PTC recurrence and PTC-related mortality ( 9

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Dario de Biase, Federica Torricelli, Moira Ragazzi, Benedetta Donati, Elisabetta Kuhn, Michela Visani, Giorgia Acquaviva, Annalisa Pession, Giovanni Tallini, Simonetta Piana and Alessia Ciarrocchi

representation of TERT and BRAF mutations distribution in HA-TC and ctrl-PTC samples (F). Occurrence of MED12 mutations in HA-TC (G) and ctrl-PTC samples (H). Most of the mutations were transitions (56.8%), followed by transversions (37

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Changjiao Yan, Meiling Huang, Xin Li, Ting Wang and Rui Ling

Nikiforov YE . The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations . Journal of Clinical Endocrinology and Metabolism 2014 99 E276 – E285

Open access

Catarina Tavares, Maria João Coelho, Catarina Eloy, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batista, Luciana Bueno Ferreira, Elisabete Rios, Samia Selmi-Ruby, Bruno Cavadas, Luísa Pereira, Manuel Sobrinho Simões and Paula Soares

) between cases with different genetic backgrounds (WT, RAS mutation, TERT p mutation, BRAF mutation, BRAF  +  TERT p mutation). The boxes represent the interquartile range; the whiskers are the 5% and 95% quartiles; the small open boxes are the mean

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June Young Choi, Jin Wook Yi, Jun Hyup Lee, Ra-Yeong Song, Hyeongwon Yu, Hyungju Kwon, Young Jun Chai, Su-jin Kim and Kyu Eun Lee

.242 ± 30.243 0.009 BRAF mutation No 258 378.672 ± 15.039 Reference V600E 236 415.103 ± 14.299 0.081 Others 5 370.710 ± 82.387 0.939 RAS mutation No 446 399.870 ± 11.187 0.257 Yes

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Ashley N Reeb, Andrea Ziegler and Reigh-Yi Lin

mutation, is the most tumorigenic of the three human FTC cell lines tested. Activating mutations in BRAF , a 766-amino acid serine/threonine-specific protein kinase, have been detected in a wide range of human malignancies. The presence of BRAF mutations