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Xuechao Jiang Scientific Research Center, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
Department of Pediatric Cardiology, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yonghui Wang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Xiaoying Li Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Leqi He Department of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Qian Yang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Wei Wang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Jun Liu Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Bingbing Zha Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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hyperthyroidism ( 4 , 5 ). B cells are the source of pathognomonic activating autoantibodies (TRAb) against TSHR in GD ( 6 , 7 ). B cells also present antigens to T cells ( 8 ). Although B cells are essential for GD pathogenesis, little is known regarding the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0045
Volume/Issue:
Volume 9: Issue 5
Open access
Bushra Shahida Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden

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Tereza Planck Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden

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Tania Singh Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden

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Peter Åsman Department of Clinical Sciences Malmö, Ophthalmology, Lund University, Malmö, Sweden
Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden

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Mikael Lantz Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden

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-stimulating hormone receptor (TSHR), commonly referred to as TRAb. These antibodies, generated by B-cell clones, prompt the production of thyroid hormones. TRAb specifically binds to TSHR, initiating the activation of the G-protein-coupled receptor (GPCR) pathway, and

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0374
Volume/Issue:
Volume 13: Issue 6
Open access
Jakub Supronik Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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Małgorzata Szelachowska Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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Adam Kretowski Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland

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Katarzyna Siewko Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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orbit is believed to occur mainly due to stimulating influence of TRAb secreted by B-cells infiltrating the thyroid gland. In consequence, the fibroblasts of the periorbital tissue are stimulated to produce extracellular matrix components and

Article Type:
Review Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0303
Volume/Issue:
Volume 11: Issue 12
Open access
Elizabeth Yan Zhang Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA

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Bao-Ting Zhu Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA
Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA

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-1 cells or NK cells are also involved in the mediation of this immune response (9, 13, 14, 15) . We have recently shown that B cells and the formation of hapten-specific antibodies (Abs) play a critical role in the pathogenesis of hapten-induced CHS

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0080
Volume/Issue:
Volume 3: Issue 4
Open access
Konstantin Yakimchuk Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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Chandrashekar Bangalore Revanna Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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Dan Huang Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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Jose Inzunza Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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Sam Okret Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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, in diffuse large B cell lymphoma (DLBCL), it was shown that the poorer survival rate in males vs females was mainly seen before women entered the menopause ( 11 ). In addition, an association of postmenopausal hormone therapy and number of pregnancies

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0459
Volume/Issue:
Volume 7: Issue 12
Open access
Christos Tsatsanis Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece
Molecular Reproductive Research Group, Department of Translational Medicine, Lund University, Malmö, Sweden
Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Greece

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Angel Elenkov Molecular Reproductive Research Group, Department of Translational Medicine, Lund University, Malmö, Sweden
Reproductive Medicine Centre, Skåne University Hospital Malmö, Malmö, Sweden

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Irene Leijonhufvud Reproductive Medicine Centre, Skåne University Hospital Malmö, Malmö, Sweden

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Katerina Vaporidi Molecular Reproductive Research Group, Department of Translational Medicine, Lund University, Malmö, Sweden

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Åsa Tivesten Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Aleksander Giwercman Molecular Reproductive Research Group, Department of Translational Medicine, Lund University, Malmö, Sweden
Reproductive Medicine Centre, Skåne University Hospital Malmö, Malmö, Sweden

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immune responses and susceptibility to autoimmunity and inflammatory diseases. B-cell activating factor (BAFF) also known as tumor necrosis factor (TNF) ligand superfamily member 13B is a cytokine of the TNF family that is causally linked to the

Article Type:
Research Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-22-0456
Volume/Issue:
Volume 12: Issue 3
Open access
W J Bom Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands

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F B M Joosten Department of Radiology, Rijnstate Hospital, Arnhem, the Netherlands

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M M G J van Borren Department of Clinical Chemistry, Rijnstate Hospital, Arnhem, the Netherlands

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E P Bom Department of Radiology, Rijnstate Hospital, Arnhem, the Netherlands

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R R J P van Eekeren Department of Surgery, Rijnstate Hospital, Arnhem, the Netherlands

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H de Boer Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands

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bars indicate that the interventions took place in the second half of the first year: white-striped red and blue bars represent interventions after the first year. The patient with a solitary B-cell lymphoma diagnosed in the second year after RFA is

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0304
Volume/Issue:
Volume 11: Issue 1
Open access
Xiaoya Zheng Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Shanshan Yu Pathology Department, Chongqing Medical University, Chongqing, China

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Jian Long Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Qiang Wei Prevention of Disease Department, Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing, China

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Liping Liu Department of Ultrasound, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chun Liu Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Wei Ren Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Representative histological figures of diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) and thyroid diffuse large B-cell lymphoma (DLBCL). (A) Histopathology of DSVPTC showing the carcinoma had numerous psammoma bodies, papillary structures and

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0364
Volume/Issue:
Volume 11: Issue 1
Open access
Weiwei Liang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Yilin Zhang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

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Yan Guo Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Pengyuan Zhang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Jiewen Jin Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Hongyu Guan Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Yanbing Li Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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-infiltrating immune cells (TIICs) was analyzed by the Tumor Immune Estimation Resource (TIMER). TIMER is a widely used tool for analyzing gene expression and infiltration of six immune cell types (B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-24-0034
Volume/Issue:
Volume 13: Issue 6
Open access
Borros Arneth Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Hospital of the Universities of Giessen and Marburg, UKGM, Justus Liebig University, Giessen, Giessen, Germany

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activation continues during the later stages of this disease. In addition, it is not known whether this reactivity is limited to B-cells or whether it also occurs in T-cells. To investigate this phenomenon in T-lymphocytes, whole blood samples from type 1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0230
Volume/Issue:
Volume 6: Issue 8
Open access