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Nassim Ghaffari-Tabrizi-Wizsy, Christina Angelika Passegger, Laura Nebel, Fabian Krismer, Gudrun Herzer-Schneidhofer, Gert Schwach and Roswitha Pfragner

excised, followed by FFPE-tissue embedding and sectioning. The tumour morphology was analysed by histology and immunostainings. In the EU the CAM assay is not declared as an animal experiment by law and even fulfils the 3R criteria (replacement

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Jia Liu, Min Liu, Zhe Chen, Yumei Jia and Guang Wang

were significantly associated with the serum levels of FT3 and FT4 (FT3: r  = −0.47, 95% CI : −0.63 to −0.27, P  < 0.01, Fig. 3A ; FT4: r  = −0.72, 95% CI : −0.81 to −0.59, P  < 0.01, Fig. 3B ). We also observed a significant positive

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Sarah J Delforce, Eugenie R Lumbers, Celine Corbisier de Meaultsart, Yu Wang, Anthony Proietto, Geoffrey Otton, Jim Scurry, Nicole M Verrills, Rodney J Scott and Kirsty G Pringle

), transforming growth factor beta 1 ( TGFB1 ) and phosphoinositide-3-kinase ( PIK3R1 ) are expressed and if their levels of expression correlate with the expression of components of the (P)RR/prorenin/angiotensin system. We also examined the expression of

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Ming Zhu, Bingxin Xu, Meng Wang, Shangyun Liu, Yue Zhang and Chao Zhang

Introduction The melanocortin receptors (MCRs) belong to α group of rhodopsin G-protein-coupled receptors. Mammalian MCRs consist of five subtypes, generally referred to as MC1R, MC2R, MC3R, MC4R and MC5R. A widely reported function of MC1R is

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Maria Angela D'amico, Barbara Ghinassi, Pascal Izzicupo, Lamberto Manzoli and A Di Baldassarre

to specific receptors (IP 3 R), a family of Ca 2 + channels responsible for the intracellular Ca 2 + mobilization from intracellular stores, such as the endoplasmic reticulum (ER) or the secretory granules. The IP 3 R/Ca 2 + channels present on the

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A J Varewijck, A J van der Lely, S J C M M Neggers, S W J Lamberts, L J Hofland and J A M J L Janssen

present pituitary deficiencies (left) (see text for details). Age-adjusted relationships between IGF1, IGFBPs, GH, and S-Klotho Total IGF1 was positively related to IGF1 bioactivity ( r =0.86, P <0.001; R 2 =0.70) and IGFBP3 ( r =0.64, P =0.02), while

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Rajae Talbi and Victor M Navarro

melanocortin receptors, MC3R and MC4R, with MC4R being the primary receptor mediating the metabolic action of melanocortins ( 28 , 29 ). On the other hand, the orexigenic AgRP and NPY peptides – both produced in AgRP neurons – increase food intake and decrease

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Tatiana V Novoselova, Peter J King, Leonardo Guasti, Louise A Metherell, Adrian J L Clark and Li F Chan

-2-receptor (MC2R)), cloned in 1992 ( 6 ), is a critical component of the HPA axis and a member of the melanocortin receptor family. Other members are MC1R, MC3R, MC4R and MC5R – the functions of which were recently reviewed elsewhere ( 4 ). MC2R is

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Kranti Khadilkar, Vijaya Sarathi, Rajeev Kasaliwal, Reshma Pandit, Manjunath Goroshi, Gaurav Malhotra, Abhay Dalvi, Ganesh Bakshi, Anil Bhansali, Rajesh Rajput, Vyankatesh Shivane, Anurag Lila, Tushar Bandgar and Nalini S Shah

Journal of Endocrinology 2014 3 R111 – R122 . ( doi:10.1530/EJE-14-0113 ) 2 DeLellis RA Lloyd RV Heitz PU Eng C. Pathology and Genetics of Tumours of Endocrine Organs. World Health Organization Classification of Tumours . Lyon

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L M Mongioì, R A Condorelli, S La Vignera and A E Calogero

adrenal insufficiency: a review . European Journal of Endocrinology 2016 3 R107 – R116 . ( https://doi.org/10.1530/EJE-15-1242 ) 10.1530/EJE-15-1242) 2 Arlt W Allolio B. Adrenal insufficiency . Lancet 2003 361 1881 – 1893 . ( https