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Tingting Jia Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China

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Ya-nan Wang Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China

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Dongjiao Zhang Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China

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Xin Xu Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China

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hormone to human body, and the intriguing finding has certified that the supplementation of vitamin D could reduce the deposition of AGEs in the medial layer of the aortic wall and systemic oxidative stress in diabetic rats ( 15 ). 1α,25-dihydroxyvitamin D

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Glenville Jones Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada

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even more potent than 25-OH-D 3 , namely 1α,25-dihydroxyvitamin D 3 (1,25-(OH) 2 D 3 ) which is now universally accepted as the hormonal form of vitamin D 3 . Several groups including Dr Kodicek’s, ( 39 ) Dr Norman’s ( 40 ) and Dr DeLuca’s ( 41 ) were

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Changwei Liu Children’s Hospital of Nanjing Medical University, Nanjing, China

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Jingwen Wang Children’s Hospital of Nanjing Medical University, Nanjing, China

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Yuanyuan Wan Children’s Hospital of Nanjing Medical University, Nanjing, China

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Xiaona Xia Children’s Hospital of Nanjing Medical University, Nanjing, China

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Jian Pan Children’s Hospital of Nanjing Medical University, Nanjing, China

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Wei Gu Children’s Hospital of Nanjing Medical University, Nanjing, China

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Mei Li Children’s Hospital of Nanjing Medical University, Nanjing, China

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Y Li Y Lv M Xue F Liu X Zhang L Yang R. Decreased immunosuppressive actions of 1α, 25-dihydroxyvitamin D3 in patients with immune thrombocytopenia . Molecular Immunology 2016 78 89 – 97 . ( https://doi.org/10.1016/j.molimm.2016.08.014 ) 7

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Cecília Cristelo i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal

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Alexandra Machado CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal

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Bruno Sarmento i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal

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Francisco Miguel Gama CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal

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differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes . Journal of Steroid Biochemistry and Molecular Biology 2015 147 17 – 23 . ( https://doi.org/10.1016/j.jsbmb.2014.11.001 ) 38 Penna G Adorini L 1α,25-Dihydroxyvitamin D3

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Giuseppe Grande Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Andrea Graziani Department of Medicine, University of Padova, Padova, Italy

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Antonella Di Mambro Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Riccardo Selice Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Alberto Ferlin Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy
Department of Medicine, University of Padova, Padova, Italy

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JL Nair KS Terzic A Sieck GC , et al . 1α,25-Dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells . Journal of Biological Chemistry 2016 291 1514 – 1528 . ( https://doi.org/10.1074/jbc

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