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Xiao-Shan Huang Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Ning Dai Zhejiang Chinese Medical University, Hangzhou, China

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Jian-Xia Xu Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Jun-Yi Xiang Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Xiao-Zhong Zheng Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Tian-Yu Ke Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Lin-Ying Ma Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Qi-Hao Shi Zhejiang Chinese Medical University, Hangzhou, China

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Shu-Feng Fan Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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hypothyroidism ( 1 ). In the majority of cases, the onset of HT is insidious, and thyroid hormone levels typically remain within the normal range until inflammation progresses to hypothyroidism, revealing initial symptoms ( 2 ). Fundamentally, HT is an

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Qing Zhou Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China

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Li Yong Zhang Department of Thyroid Surgery, Minimal Invasive Center, Fujian Medical University Union Hospital, Fuzhou, China

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Mei Feng Dai Department of Clinical Lab, Fujian Maternity and Child Health Hospital, Fuzhou, China

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Zhen Li Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China

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Chao Chun Zou Department of Endocrinology, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China

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Hui Liu Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China

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visceral adiposity, and systemic chronic inflammation. On the one hand, ER stress upregulates inflammatory gene expression and increases pro-inflammatory cytokine production. On the other hand, as a key mediator of ER stress that leads to insulin resistance

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Bushra Shahida Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden

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Tereza Planck Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden

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Tania Singh Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden

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Peter Åsman Department of Clinical Sciences Malmö, Ophthalmology, Lund University, Malmö, Sweden
Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden

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Mikael Lantz Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden

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inflammation both by recruiting mononuclear cells to the site of inflammation and by systemically elevating the numbers of B- and T-lymphocyte populations; these results explain the severe state of GO in smokers and may in part explain the association of

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Xiaowen Zhang Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

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Chen Han Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
Department of Endocrinology and Metabolism, Drum Tower Clinical Medical College, Southeast University, Nanjing, China

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Hongwei Wang State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China

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Xinghong Sun Department of Ophthalmology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China

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Xin Dou Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China

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Xueying He Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China

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Di Wu Department of Radiology, Southeast University Medical School Affiliated Zhongda Hospital, Nanjing, China

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Shanmei Shen Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

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Dalong Zhu Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

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Xinlin Zhang Department of Cardiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China

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Yan Bi Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China

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indicator of systemic inflammation. NLR has been reported to be associated with clinical prognosis in multiple disease contexts, including thyroid diseases ( 8 , 9 ). NLR predicts relapse in GD patients following antithyroid drug therapy ( 10 ) and disease

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Jakub Supronik Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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Małgorzata Szelachowska Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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Adam Kretowski Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland

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Katarzyna Siewko Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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phase when the inflammation is ongoing but not progressive, and lastly an inactive phase ( 6 ). There are several known risk factors of severe course of the disease, including male sex, smoking, thyroid dysfunction, treatment with radioiodine, high

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Zhengrong Jiang Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

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Linghong Huang Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

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Lijun Chen Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

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Jingxiong Zhou Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

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Bo Liang Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

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Xuefeng Bai Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

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Lizhen Wu Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

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Huibin Huang Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

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through the ceRNA network, such as rheumatoid arthritis, systemic lupus erythematosus, and ulcerative colitis ( 5 , 6 , 7 , 8 ). However, there are few studies on the involvement of circRNAs in the mechanisms underlying GD pathogenesis. Sun et al

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Hui Li Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.

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Peng Wu Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.

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patterns capable of distinguishing between benign and malignant thyroid nodules with high accuracy ( 51 ). Similarly, alterations in histone modification patterns, as demonstrated in several studies, have been proposed as markers of aggressive disease and

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Yuting Shao Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Xiaole Hu Department of Operating Room, Qilu Hospital of Shandong University, Shandong, China

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Yuxi Wang Department of Breast and Thyroid Surgery, People’s Hospital of Mengyin County, Linyi, Shandong, China

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Yi Shao Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Luchuan Li Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Qingdong Zeng Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Hong Lai Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Lei Sheng Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India . Diabetes Research and Clinical Practice 2014 103 e18 – e23 . ( https://doi.org/10

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