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on systemic and adipose tissue inflammation in db/db mice. To identify and quantify macrophages within epididymal white adipose tissue (eWAT), we immunohistochemically stained sections for the F4/80 antigen, a specific marker for mature macrophages
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increased insulin secretion from β-cells. It is widely accepted that the pathogenesis of insulin resistance is involved with ectopic lipid accumulation and systemic inflammation ( 42 ). CysC mRNA expression and CysC release by subcutaneous and omental
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findings, our study also revealed decreased frequencies of Tregs and PD-1 + Tregs in patients with type 2 diabetes compared to healthy controls, suggesting a loss of T cell homeostasis that may contribute to tissue-specific and systemic inflammation as
Postgraduate Program in Nutritional Sciences, Department of Nutrition, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
University Centre of João Pessoa (UNIPE), João Pessoa, Paraíba, Brazil
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Postgraduate Program in Cognitive Neuroscience and Behavior, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Department of Biorregulation, Health Sciences Institute, Federal University of Bahia, Bahia, Brazil
Postgraduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
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associated with insulin resistance, worse metabolic health, and systemic inflammation; many authors have discussed that fat distribution itself would be a better marker of worse outcomes in COVID-19, and research helps to corroborate that hypothesis ( 26
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develop type 2 diabetes mellitus 10 years after GDM ( 2 , 3 , 4 , 5 ). Women with GDM typically have different levels of insulin resistance and possible chronic low-grade inflammation, which trigger vascular injury and dysfunction and subsequent
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glucose clearance. It is responsible for the majority of glucose uptake in the postprandial state and is also considered as the primary driver of systemic insulin resistance ( 6 , 7 ). Due to its crucial role in systemic glycometabolism, skeletal muscle
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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A Cappuccilli M Totti V Santoro A Franceschi C Salvioli S . Gdf15 plasma level is inversely associated with level of physical activity and correlates with markers of inflammation and muscle weakness . Frontiers in Immunology 2020 11 915
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States . JAMA 2011 305 2532 – 2539 . ( https://doi.org/10.1001/jama.2011.861 ) 32 Guo W Song Y Sun Y Du H Cai Y You Q Fu H & Shao L . Systemic immune-inflammation index is associated with diabetic kidney disease in type 2 diabetes
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inhibit the systemic inflammatory response and regulate the function of pancreatic islets based on this pancreas–inflammation–intestine regulatory axis, which once again clarifies the inseparable relationship between the pancreas, inflammation, and
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, increase IRISIN production and secretion, upregulate Ucp1 in WAT ( 5 ), increase energy consumption, and promote WAT conversion to beige adipose tissue, effectively achieving the goal of adipose loss ( 14 ). A study generated a mouse model with systemic