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-up clinical, hormonal, and radiological data, and glucocorticoid regimen details (including dose, route, duration, and adverse events if any). The patients were divided into two groups, the oral steroid group (OSG) and the i.v. glucocorticoid group (IVSG
Division of Endocrinology, Mid and South Essex NHS Trust, Broomfield, UK
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the HPA axis; f HPA axis could not be evaluated because these patients died (patient #3) or was on high-dose steroids for inflammatory myositis (patient# 8). ACTH, adrenocortical hormone; COVID-19, coronavirus disease- 2019; MP
Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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cancer, may be influenced by sex hormones ( 48 , 49 , 50 ). This raises the question whether cancer or brain tumors diagnosed during childhood may be influenced by sex steroids, during treatment or after achieving complete remission, and whether sex
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, 7 ). Like GH, serum IGF1 levels rise during puberty and decline with aging ( 23 ) and tend to be low early in life and in patients with obesity ( 24 ) that may overlap with GH-deficient patients. Thyroid hormone and sex steroids also may exert
Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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-021-01700-7 ) 8 Cai Z Zhong J Jiang Y Zhang J . Associations between COVID-19 infection and sex steroid hormones . Frontiers in Endocrinology (Lausanne) 2022 13 940675. ( https://doi.org/10.3389/fendo.2022.940675 ) 9 Mohamad NV Wong SK Wan Hasan
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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%) were currently treated with thyroid hormone, 8 (20%) with hydrocortisone, and 12 (29%) with sex steroids ( Table 2) . In total, 15% ( n = 6), 7% ( n = 3), and 7% ( n = 3) had two, three, and four hormonal deficiencies, respectively, excluding GHD
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to hypothalamic–pituitary-–gonad axis (HPG) axis: adolescents (males aged 14–18 years, females aged 13–18 years) had follicle-stimulating hormone, luteinizing hormone levels, and sex steroid hormones below the Tanner stage 2 reference values or bone
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Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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hormone deficiencies is not fully understood but may result from a combination of damage to hypothalamic nuclei, portal vasculopathy, pituitary fibrosis, or the development of pituitary atrophy secondary to hypothalamic damage. HP dysfunction can present
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Italian standards ( 23 ). Pubertal stage was recorded according to Marshall and Tanner’s genital stage ( 24 ), using Prader orchidometer for testicular volume ( 25 ). The following hormone levels were recorded at baseline, when available: follicle
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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2019 to December 2020 and from January 2021 to December 2021 served as the training cohort and the validation cohort, respectively. We excluded those patients who were aged less than 18 years. Postoperative steroid regime was similar across the cohort