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Introduction Steroid hormones are signaling molecules involved in regulation of electrolyte concentrations, blood pressure, reproductive functions, and metabolism ( 1 ). A lack or an excess of steroids results from enzyme defects, adenomas, or
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female reproductive events. Further, ovarian tumors are considered sensitive to sex steroid hormones, as they are mediated by specific androgen, estrogen, and progesterone receptors ( 3 ). Additionally, the steroid hormone receptor shows a particular
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steroids have been used, then standard approaches to weaning should be followed, but if after a prolonged period there has been no recovery of endogenous cortisol production, then the possibility of co-existent ACTH deficiency should be considered. Hence
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-smoking, and BMI 20–25 kg/m 2 . The exclusion criteria were use of any narcotics for the last 3 months, previous or present use of anabolic steroids, and previous liver or heart disease or stroke. Fasting blood samples, taken before 10:00 h, were collected at
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,965 (57) 53,531 (51) <0.0001 Statins 7945 (28) 27,092 (26) <0.0001 Antidiabetics 3683 (13) 11,693 (11) <0.0001 *Defined as having a dispensation in the period before index date (i.e. ever use). NSAID, non-steroidal
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D Ghidini M Ghidini A Pizzutilo EG Ruggieri L Cabiddu M Borgonovo K Dognini G Brighenti M Association of steroids use with survival in patients treated with immune checkpoint inhibitors: a systematic review and meta
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.1016/s0197-4580(0000123-8 ) 27 Berman KF Schmidt PJ Rubinow DR Danaceau MA Van Horn JD Esposito G Ostrem JL & Weinberger DR . Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study
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) and estrogen receptor alpha (ERα), two other steroid receptors crucial for bone formation and remodeling ( 71 ). VDR, in turn, regulates the activity of p27Kip1 and p18Ink4c (their potential role in bone metabolism has been discussed earlier) ( 72