L Ghataore
L Ghataore
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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I Chakraborti
I Chakraborti
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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S J Aylwin
S J Aylwin
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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K-M Schulte
K-M Schulte
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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D Dworakowska
D Dworakowska
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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P Coskeran
P Coskeran
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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N F Taylor
N F Taylor
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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in widespread use since publication in 2007 of the large retrospective study of Terzolo et al . (3) . Accumulated knowledge of the mode of action of mitotane together with its effects on steroid synthesis and catabolism is patchy. Mitotane targets
Britt J van Keulen
Britt J van Keulen
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Michelle Romijn
Michelle Romijn
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Bibian van der Voorn
Bibian van der Voorn
Department of Pediatric Endocrinology, Sophia Kinderziekenhuis, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Marita de Waard
Marita de Waard
Emma Children’s Hospital, Amsterdam University Medical Centers, locations AMC and VUmc, Amsterdam, The Netherlands
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Michaela F Hartmann
Michaela F Hartmann
Steroid Research and Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Pediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University, Giessen, Germany
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Johannes B van Goudoever
Johannes B van Goudoever
Emma Children’s Hospital, Amsterdam University Medical Centers, locations AMC and VUmc, Amsterdam, The Netherlands
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Stefan A Wudy
Stefan A Wudy
Steroid Research and Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Pediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University, Giessen, Germany
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Joost Rotteveel
Joost Rotteveel
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
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Martijn J J Finken
Martijn J J Finken
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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and thawed only once just before analysis. After placement in a salivette, the pad was centrifuged at 1900 g for 5 min, enabling the extraction of urine. Urinary steroids were determined using quantitative data produced by gas chromatography
P Herbert
P Herbert
School of Sport, Health and Outdoor Education, Trinity Saint David, University of Wales, Wales, UK
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LD Hayes
LD Hayes
Active Ageing Research Group, Department of Medical and Sport Sciences, University of Cumbria, Lancaster, UK
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NF Sculthorpe
NF Sculthorpe
Institute of Clinical Exercise and Health Science, University of the West of Scotland, Scotland, UK
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FM Grace
FM Grace
Faculty of Health, Federation University, Victoria, Australia
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-frequency HIIT would improve PPO compared with normal exercise training and (ii) systemic steroid hormones would be unchanged following low-frequency HIIT in masters athletes. Materials and methods Participants Following familiarization with
Britt J van Keulen
Britt J van Keulen
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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Conor V Dolan
Conor V Dolan
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Bibian van der Voorn
Bibian van der Voorn
Department of Pediatric Endocrinology, Sophia Kinderziekenhuis, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Ruth Andrew
Ruth Andrew
Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK
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Brian R Walker
Brian R Walker
Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
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Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
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Hilleke Hulshoff Pol
Hilleke Hulshoff Pol
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
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Dorret I Boomsma
Dorret I Boomsma
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Joost Rotteveel
Joost Rotteveel
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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Martijn J J Finken
Martijn J J Finken
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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cortisol levels. Compared to girls, boys, up to age 8, had higher salivary cortisol levels and lower levels beyond this age ( 11 ). The timing of this change suggests that sex steroids influence the HPA axis. Surprisingly, to the best of our knowledge
Aneta Gawlik
Aneta Gawlik
Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Michael Shmoish
Michael Shmoish
Bioinformatics Knowledge Unit, Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion – Israel Institute of Technology, Haifa, Israel
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Michaela F Hartmann
Michaela F Hartmann
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Stefan A Wudy
Stefan A Wudy
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Zbigniew Olczak
Zbigniew Olczak
Department of Diagnostic Imaging, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Katarzyna Gruszczynska
Katarzyna Gruszczynska
Department of Diagnostic Imaging, School of Medicine in Katowice, Medical University of Silesia, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Ze’ev Hochberg
Ze’ev Hochberg
Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
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there is possibility of multiple diagnoses or before starting therapy with potentially hepatotoxic medications’ ( 8 ). The consequences of obesity-related NAFLD on liver metabolism are insufficiently understood ( 8 ). As steroid hormones are partially
Thomas Reinehr
Thomas Reinehr
Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Witten, Germany
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Alberto Sánchez-Guijo
Alberto Sánchez-Guijo
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Giessen, Germany
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Nina Lass
Nina Lass
Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Witten, Germany
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Stefan A Wudy
Stefan A Wudy
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Giessen, Germany
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Introduction Obesity is a complex condition associated with changes in many steroid hormones also including androgens: concentrations of testosterone and DHEAS and their precursors are increased in children ( 1 , 2 ) and obese women ( 3
Lawrence D Hayes
Lawrence D Hayes
Active Ageing Research Group, Department of Medical and Sport Sciences, University of Cumbria, Lancaster, UK
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Peter Herbert
Peter Herbert
School of Sport, Health and Outdoor Education, Trinity Saint David, University of Wales, Carmarthen, UK
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Nicholas F Sculthorpe
Nicholas F Sculthorpe
Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, UK
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Fergal M Grace
Fergal M Grace
Faculty of Health, Federation University, Victoria, Australia
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Introduction Testosterone is a sex steroid hormone with profound influence on various tissues ( 1 , 2 , 3 ). The precipitous decline in systemic testosterone with age is well described ( 4 ). Additionally, sex hormone-binding globulin (SHBG
Willem de Ronde
Willem de Ronde
Department of Internal Medicine, Spaarne Gasthuis, Haarlem, the Netherlands
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Diederik L Smit
Diederik L Smit
Department of Internal Medicine, Spaarne Gasthuis, Haarlem, the Netherlands
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Introduction Every now and then a clinical endocrinologist will be visited by a patient that uses anabolic androgenic steroids (AAS) or has been using them in the past. The interaction between doctor and patient may be hampered for a number of
T P Parikh
T P Parikh
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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B Stolze
B Stolze
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
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Y Ozarda
Y Ozarda
Department of Medical Biochemistry, Faculty of Medicine, Uludag University, Bursa, Turkey
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J Jonklaas
J Jonklaas
Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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K Welsh
K Welsh
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
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L Masika
L Masika
Department of Laboratory Medicine and Pathology/National Health Laboratory Service Walter Sisulu University, Mthatha, South Africa
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M Hill
M Hill
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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A DeCherney
A DeCherney
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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S J Soldin
S J Soldin
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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Introduction Diurnal variations in the serum concentration of steroid hormones and their metabolism, as assessed by urinary excretion, have long been known for cortisol and testosterone ( 1 , 2 , 3 ). Less information exists for the other up
Henrik Ryberg
Henrik Ryberg
Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Anna-Karin Norlén
Anna-Karin Norlén
Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Andreas Landin
Andreas Landin
Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Per Johansson
Per Johansson
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Zeinab Salman
Zeinab Salman
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Anders Wallin
Anders Wallin
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Johan Svensson
Johan Svensson
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology, Skaraborg Central Hospital, Skövde, Sweden
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Department of Endocrinology, Skaraborg Central Hospital, Skövde, Sweden
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Claes Ohlsson
Claes Ohlsson
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Introduction Sex steroid hormones are predominantly produced from cholesterol by the gonads and the adrenal glands. Then, the sex steroids are distributed to target tissues through the circulation. In addition, many tissues and organs
